データ・AIのスキル

Build comprehensive DNA methylation maps by aggregating WGBS (Whole Genome Bisulfite Sequencing) data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is DNA methylated/unmethylated in my tissue?" by combining per-CpG methylation data into tissue-level methylation profiles. Handles coverage filtering, identifies hypomethylated regions (HMRs) and partially methylated domains (PMDs), and manages cross-lab variation.

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Guide for using JASPAR transcription factor binding profiles with ENCODE ChIP-seq data. Use when users need to find TF binding motifs in ENCODE peaks, validate ChIP-seq targets with known motifs, or scan regulatory regions for TF binding potential. Trigger on: JASPAR, motif database, binding profile, PWM, position weight matrix, TF motif, motif enrichment, motif scanning, binding site prediction.

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Plan and execute integrative analysis combining multiple ENCODE experiments for cross-dataset or multi-omic workflows. Use when the user wants to combine experiments, perform cross-dataset comparison, multi-omic integration, peak overlap analysis, differential binding, signal correlation, chromatin state segmentation, enhancer-gene linkage, or any analysis that requires merging or comparing data from two or more ENCODE experiments. Covers same-assay cross-sample, multi-omic same-sample, cross-organism, and perturbation integration designs. Guides compatibility checks, batch effect detection, normalization, integration strategy selection, and provenance documentation.

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Build comprehensive histone mark maps by aggregating narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is this histone mark present in my tissue?" by combining peak calls from multiple studies into a union peak set with confidence annotations. Handles cross-lab batch effects, broad vs narrow marks, and ENCODE blocklist filtering.

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Guide for integrating NHGRI-EBI GWAS Catalog associations with ENCODE regulatory data. Use when users need to find GWAS variants in ENCODE peaks, connect regulatory elements to disease associations, or prioritize functional variants using ENCODE annotations. Trigger on: GWAS, genome-wide association, SNP association, trait association, GWAS Catalog, disease association, risk variant, lead SNP, LD proxy.

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Guide for integrating GTEx tissue expression data with ENCODE regulatory elements. Use when users need to check if a gene is expressed in a tissue, correlate regulatory elements with expression, or validate ENCODE findings against GTEx. Trigger on: GTEx, tissue expression, gene expression levels, expression atlas, eQTL, tissue-specific expression, TPM values.

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Spring Boot 4 data layer implementation for Domain-Driven Design. Use when implementing JPA or JDBC aggregates, Spring Data repositories, transactional services, projections, or entity auditing. Covers aggregate roots with AbstractAggregateRoot, value object mapping, EntityGraph for N+1 prevention, and Spring Boot 4 specifics (JSpecify null-safety, AOT repositories). For DDD concepts and design decisions, see the domain-driven-design skill.

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Analyze system architecture, module structure, API contracts, data models, and code patterns. Use when designing systems, reviewing module boundaries, evaluating API designs, analyzing data models, checking pattern conformance, tracing decisions, or reviewing frontend architecture. Triggers: "architecture", "module design", "API design", "data model", "boundaries", "patterns", "decisions", "frontend architecture".

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Converts natural-language descriptions or UI spec files into optimized Google Stitch prompts. Use when creating, refining, or validating design directives for Google Stitch. Use when user says "create a Stitch prompt", "optimize this for Stitch", "convert this spec to a Stitch prompt", "write a UI prompt", or mentions Google Stitch prompt authoring. Follows Stitch best practices with short, directive prompts focused on screens, structure, and visual hierarchy.

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Generates Stitch screens from authored prompt files using MCP tools. Reads prompt sections, sends each to Stitch for generation, and fetches resulting images and code. Use when user mentions "generate in stitch", "create stitch screens", "run prompts in stitch", "send prompts to stitch", "generate screens from prompts", "fetch stitch images", or has prompt-v*.md files ready for generation. Requires Stitch MCP server.

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Rapid UI prototyping — generates 3 visually distinct HTML/CSS components from a text prompt and serves them in a live browser gallery. Use when user runs /prototype, asks to "prototype a UI", "mock up a component", "generate HTML mockups", "create UI variations", "design exploration", "quick UI concept", or wants to see multiple visual approaches to a component. Also trigger when user says "show me different ways to build...", "explore different designs for...", or wants rapid visual exploration of a UI idea — even without saying "prototype" explicitly.

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Transform vague inputs into precision-optimized AI prompts for Claude, ChatGPT, Gemini, or other LLMs. Use when user mentions "optimize prompt", "improve prompt", "lyra", "prompt engineering", or needs help crafting effective AI prompts.

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Use this when the user wants to generate, normalize, verify, deduplicate, or export training datasets for Codex, Antigravity, or Claude Code from topics, URLs, reference material, web research, or existing JSONL/CSV files. Supports SFT and DPO workflows, custom export schemas, and deterministic local pipeline scripts.

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Craft high-quality natural-language image prompts for any modern text-to-image or image-edit model that accepts flowing English. Trigger when the user wants help writing, rewriting, improving, or translating an English natural-language image prompt — including "write me an image prompt", "improve this image prompt", "describe this scene for an image model", or "convert these tags into a natural language prompt". Do NOT trigger for requests that are purely about dispatching to an image API, choosing samplers/schedulers, picking LoRAs, or setting up ControlNet — those belong to a runtime skill.

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Guidance for Tauri v2 stronghold plugin with encrypted storage and sensitive data handling.

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Guidance for Tauri v2 NFC plugin with session handling and data validation.

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Guidance for Tauri v2 SQL plugin setup, migrations, and safe query access.

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Evaluate code (especially LLM-generated) for structural simplicity using Rich Hickey's "Simple Made Easy" framework. Use this skill whenever reviewing a PR, diff, or code snippet for accidental complexity — particularly when the code was generated by an AI coding assistant and line-by-line review isn't feasible. Also use when the user asks about complecting, simplicity vs. easiness, structural coupling, or concept deduplication. Trigger on phrases like "is this simple", "does this complect", "review for complexity", "structural analysis", or any reference to Hickey, Simple Made Easy, or grey-box review.

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Review Circuit Weaver's exhaustive placement proposal and apply approved SVG coordinates to a real electrically annotated KiCad PCB. Use after schematic generation for placement optimization, official-reference review, interactive SVG editing, strict reference reconciliation, and PCB placement handoff. Do not treat review artifacts as fabrication data.

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Search DigiKey by keyword or part number, check stock and price breaks, retrieve component specifications, and download or synchronize datasheets for an electronics project. Use when the user explicitly wants DigiKey data, a DigiKey prototype-order comparison, or direct datasheet synchronization. For distributor-neutral sourcing, multi-vendor price comparison, or order-file generation, use the bom skill instead.

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Run a task iteratively over a user-specified duration by dispatching subagents. The orchestrator stays strictly linear and time-checked, but each iteration fans out MULTIPLE subagents in parallel over independent units (and those subagents may fan out further). Shared state — a compact progress digest and a growing environment cheatsheet — lives on disk and is passed to every subagent BY REFERENCE, killing the per-subagent rediscovery tax. Every subagent first reads an initialiser preamble that points it at that shared state and makes it write findings back, so the cheatsheet populates itself; role prompts are produced ONCE on the filesystem by a single scaffold command and dispatched by path, never re-typed per dispatch. Subagents persist their results to disk and return only a tiny status, so the orchestrator's context stays small and lasts. The orchestrator classifies the goal as FINITE or OPEN-ENDED: finite lists may finish early; open-ended goals use the full duration, never idle, never manufacture busywork. Use when the user gives a task and a duration and wants it ground out iteratively by subagents over that time.

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Create custom modules for [Harbor Boost](https://github.com/av/harbor/tree/main/boost), an optimizing LLM proxy. Use when building Python modules that intercept/transform LLM chat completions—reasoning chains, prompt injection, structured outputs, artifacts, or custom workflows. Triggers on requests to create Boost modules, extend LLM behavior via proxy, or implement chat completion middleware.

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Use when the user wants to systematically fix AI code slop — duplicated logic, over-engineering, silent error swallowing, convention drift, cargo-cult patterns, and other LLM-introduced architectural decay — over a specified duration

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Performs static analysis of binary code using radare2 and Ghidra — function enumeration, cross-reference tracing, decompilation, and control flow graphs without executing the binary. Use when disassembling or decompiling code, mapping functions, tracing data flow, or building hypotheses before dynamic verification.

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