デザインのスキル

Check that the UI you actually rendered uses the design system, by reading computed styles in the running app against the project's design tokens. Catches hardcoded hex colors, off-palette backgrounds, invisible or unusable controls, and animations that never ran. Use after building or restyling a component, when a design review is wanted, when a UI looks slightly off but nobody can say why, or when a design system exists and nothing checks whether the code follows it.

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Check that a change to a web app actually works in the running app before calling it done. Drives the real page and returns a pass/fail verdict with the request that fired, the state that moved, and the file:line to fix. Use after editing a component, a form, a route, or an API call; when you have said "fixed" but have not opened the app; when the user asks "does it actually work?"; or when a change looks right on screen and you cannot prove it.

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Use this skill to run multiple Simulink simulations in parallel with parsim, batchsim, and DesignStudy. TRIGGER when: user asks for parameter sweep, sweeping/varying parameters across simulations, Monte Carlo study, batch simulation, running multiple simulations, parallel simulations, large-scale multiple simulations, any task involving repeated simulations with different parameter values, user mentions having an existing script/function for parameter sweeps, or user wants to migrate from parfor/set_param/for-loop patterns to recommended workflows.

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Specify plant models for closed-loop simulation: system specs, architecture, build plans, validation plans. Use when creating, updating, or reviewing plant model specifications, planning plant model architecture, or planning plant model validation.

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Specify algorithms for Model-Based Design: system specs, architecture specs, implementation plans, test plans. Use when creating specifications for controllers, signal processing, diagnostics, estimators, or other algorithms authored in Simulink, Stateflow, System Composer, or MATLAB Function blocks.

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Sanitize and anonymize a Simulink model for external sharing. Use when stripping proprietary content, anonymizing block/signal names, removing metadata, or creating a shareable reproduction model for bug reports. Do NOT use for simply copying or sharing a model internally.

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Configures Simulink simulations non-destructively using SimulationInput objects — parameter overrides without modifying the model, batch sweeps via parsim, custom input signals via Dataset, and simulation data retrieval via logsout. Use when running sim()/parsim() with setVariable, setBlockParameter, setExternalInput, or when performing parameter sweeps and multi-run analysis. Not needed for one-shot simulations without configuration.

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Manages MATLAB projects for Simulink workflows: path management, file registration, labels, source control configuration, and project lifecycle. Use when creating projects, adding models/dictionaries/requirements to projects, configuring labels for automation, fixing broken model references, or setting up source control for Simulink artifacts.

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Generates draft requirements from Simulink models. Use when drafting or updating requirement artifacts from a model. Prefers Requirements Toolbox (.slreqx) when available; falls back to structured YAML.

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Generate a standalone bug report that another developer can use to reproduce, investigate, and fix an issue. Use when the user says 'file a bug', 'write a bug report', 'report this issue', or asks to document a defect for handoff.

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Guide users through creating and managing .satk/block-policy.json for controlling which blocks the agent can use, which are excluded, and which block parameters the agent should not modify. Use when setting up block usage policy for a project.

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Builds and edits Simulink, System Composer, Stateflow, and Simscape models. Use when modifying model structure, parameters, ports, connections, or Stateflow chart internals.

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Register, add, or update existing custom Simulink block libraries and configure block policy and knowledge index. Use when a user wants to register, set up, configure, or add existing .slx library files for agent-assisted model building. Do NOT use when the user wants to create or author a new library from scratch — that requires building-simulink-models.

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Use this skill when the user wants to curate the SATK library knowledge index for a Simulink project — mark commonly used blocks, correct auto-assigned block categories, or improve block descriptions so the model-building agent picks better blocks from custom libraries. Triggered by phrases like "mark blocks common", "improve block descriptions", "correct block category", "make the agent prefer certain blocks", and from Gate 3 of building-simulink-models.

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Design .NET types for performance. Seal classes, use readonly structs, prefer static pure functions, avoid premature enumeration, and choose the right collection types.

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Guidelines for introducing and using nullable reference types (NRT) and System.Diagnostics.CodeAnalysis nullable attributes in C# / .NET codebases. Covers the nullability model, flow analysis, the null-forgiving operator, API design rules, the full attribute catalog (AllowNull, DisallowNull, MaybeNull, NotNull, NotNullWhen, MaybeNullWhen, NotNullIfNotNull, MemberNotNull, MemberNotNullWhen, DoesNotReturn, DoesNotReturnIf), the C# 14 field keyword, incremental migration of legacy codebases, and a code-generation checklist.

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Design stable, compatible public APIs using extend-only design principles. Manage API compatibility, wire compatibility, and versioning for NuGet packages and distributed systems.

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Provides guidance for implementing OpenTelemetry instrumentation in .NET codebases, covering tracing (Activities/Spans), metrics, logs, naming conventions, error handling, performance, SDK setup, resources, context propagation, and API design best practices.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Designs pegRNAs and nicking guides for prime editing (PE) -- choosing the nick/strand, tuning the primer-binding site (PBS) and reverse-transcription template (RTT) as a per-locus panel, selecting the PE system (PE2/PE3/PE3b/PE4/PE5/PEmax/PE7), adding MMR-evading and PAM-disrupting silent edits, appending epegRNA 3' motifs (tevopreQ1/mpknot), and ranking with PRIDICT/DeepPrime. Covers twinPE/PASTE for large insertions and the prime-vs-base-editing decision. Use when designing a scarless point mutation, small insertion/deletion, or any of the 12 base conversions without a double-strand break, when efficiency is low and MMR inhibition or pegRNA stabilization is needed, or when routing a large insertion to an integrase method. Generic guide scoring and base editing are separate skills.

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Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

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Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.

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Predict B-cell and T-cell epitopes for vaccine antigen design and epitope mapping with BepiPred-3.0, DiscoTope-3.0, the IEDB tools, and EL-mode MHC presentation. Encodes the load-bearing asymmetry that T-cell epitope prediction is mature (it reduces to MHC presentation, AUC>0.9) while B-cell prediction is unreliable (linear predictors ~AUC 0.6 because ~90% of real epitopes are conformational) — so structure-based DiscoTope-3.0 on AlphaFold models is the only defensible B-cell path, propensity scales are obsolete, and NetChop is largely redundant on EL-trained models. Use when mapping epitopes or selecting vaccine antigens. MHC binding lives in mhc-binding-prediction.

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Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

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