開発のスキル

Terminal-Interface, Desktop-App und IDE-Extension Doku lesen Der Open-Source AI-Coding-Agent [*] Mit über 195,000 GitHub-Stars, 950 Contributors und ü

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F Agent Memory: A Git-Native Persistent Memory Solution for AI Coding Agents and Project Knowledge Management OKF Agent Memory introduces a standardiz

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Use for the self-evolving civilization - skills, memories, swarm agents, energy economy, grid duels, metacognition. Run `python scripts/autonomous_loop.py --loop` from the repo root (or `darwin_engine.py --full` for skill evolution only).

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March 27, 2026 2 min read --> --> --> --> --> Uncomfortable Truths About AI Coding Agents: What the Industry Needs to Know Artificial intelligence is

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Query ARCHS4 REST API for uniformly processed RNA-seq expression, tissue patterns, co-expression across 1M+ human/mouse samples. Retrieve z-scores, co-expressed genes, samples by metadata, HDF5 matrices. For variant population genetics use gnomad-database; for pathway enrichment use gget-genomic-databases (Enrichr).

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Access AlphaFold DB's 200M+ predicted structures by UniProt ID. Download PDB/mmCIF, analyze pLDDT/PAE, bulk-fetch proteomes via Google Cloud. For experimental structures use PDB; for prediction use ColabFold or ESMFold.

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Use after generating code, after accepting AI suggestions, or when reviewing AI-written modules. Also use when code works but feels brittle, when error handling seems thin, when orphaned resources or missing cleanup are suspected, or when the agent claims done but hidden debt may exist. Catches the specific failure patterns AI agents produce that humans would not.

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Eliminates AI-generated writing patterns that erode reader trust. Use when writing or editing articles, docs, or press releases.

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AiZynthFinder retrosynthetic route planning (CASP) from AstraZeneca Molecular AI. Monte Carlo tree search guided by a template-based neural expansion policy recursively disconnects a target SMILES until precursors are found in a purchasable stock. Covers config.yml (v4 format), aizynthcli batch screening, the AiZynthFinder/AiZynthExpander Python API, one-step disconnections, custom stocks via smiles2stock, scorers, Retro*/breadth-first/DFPN search alternatives, and reading output.json.gz / trees.json. Use for synthesis route planning, synthesizability screening, and building-block/precursor search. For reaction barriers use neb-irc-activation-energy; for 2D reaction scheme drawing use rdkit-chemdraw-cdxml.

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Patterns and architectures for autonomous Claude Code loops — from simple sequential pipelines to RFC-driven multi-agent DAG systems.

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Creating algorithmic art using p5.js with seeded randomness and interactive parameter exploration. Use this when users request creating art using code, generative art, algorithmic art, flow fields, or particle systems. Create original algorithmic art rather than copying existing artists' work to avoid copyright violations.

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Retrieve and analyze AlphaFold predicted structures for a protein. Use when the user provides a specific UniProt Accession ID and wants structural confidence metrics (pLDDT), domain boundary analysis, or disorder assessment. Do not use if the user only has a protein name, gene name, or amino acid sequence — ask for a UniProt ID first.

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Master Python asyncio, concurrent programming, and async/await patterns for high-performance applications. Use when building async APIs, concurrent systems, or I/O-bound applications requiring non-blocking operations.

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Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.

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API hardening for Express, FastAPI, and serverless. Use for rate limiting, CORS, input validation, API keys, or OWASP API Top 10.

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Search and retrieve preprints from arXiv via the Atom API. Use this skill when searching for papers in physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering, or economics by keywords, authors, arXiv IDs, date ranges, or categories.

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Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.

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Migrate from AngularJS to Angular using hybrid mode, incremental component rewriting, and dependency injection updates. Use when upgrading AngularJS applications, planning framework migrations, or modernizing legacy Angular code.

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Extract clean Markdown or text from one or more known URLs through Tavily. Use when the user supplies specific pages and needs their content, including query-focused chunks or JavaScript-rendered pages.

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Four-phase debugging framework that ensures root cause investigation before attempting fixes. Never jump to solutions.

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Vite 8.0.10 build tooling — HMR, fast builds, plugins, and optimized production assets. Use when configuring Vite, setting up React/Vue projects with Vite, or optimizing frontend build performance.

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Create isolated git worktrees with smart directory selection and safety verification

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Route Tavily web-search, extraction, mapping, crawling, and cited-research requests to the narrowest `tvly` command. Use for command-line Tavily work, installation checks, authentication setup, or choosing among the specialized Tavily skills.

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Deploy and manage projects on Vercel using token-based authentication. Use when working with Vercel CLI using access tokens rather than interactive login — e.g. "deploy to vercel", "set up vercel", "add environment variables to vercel".

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