テスト設計、脆弱性診断、品質保証（1.3万 件）
Analyze session replay patterns across experiment variants to understand user behavior differences. Use when the user wants to see how users interact with different experiment variants, identify usability issues, compare behavior patterns between control and test groups, or get qualitative insights to complement quantitative experiment results.
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Diagnostic test / biomarker accuracy — sensitivity, specificity, PPV, NPV, likelihood ratios, accuracy from a 2x2 table; ROC curve, AUC, and the optimal cutoff (Youden) for a continuous biomarker; and post-test probability via Bayes. Use when you have test results vs a gold standard (binary 2x2, or a continuous score + true labels) and need to judge how good the test is, pick a threshold, or compute the probability of disease given a result. Emphasizes the prevalence-dependence of PPV/NPV.
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Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.
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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.
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Comprehensive ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiling for drug candidates. Integrates ADMET-AI predictions, SwissADME drug-likeness, PubChemTox experimental toxicity, ChEMBL clinical data, Lipinski rule-of-five, and CYP interaction data. Use for drug-likeness assessment, BBB penetration, bioavailability, hepatotoxicity prediction, ADME/PK profiling, or screening compound libraries before lab testing.
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Automated LLM-driven hypothesis generation and testing on tabular datasets. Use when you want to systematically explore hypotheses about patterns in empirical data (e.g., deception detection, content analysis). Combines literature insights with data-driven hypothesis testing. For manual hypothesis formulation use hypothesis-generation; for creative ideation use scientific-brainstorming.
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Analyzes chemical libraries by scaffold using Bemis-Murcko scaffolds, generic frameworks, cyclic skeletons, matched molecular pair (MMP) analysis via mmpdb, R-group decomposition, Free-Wilson analysis, scaffold hopping, and chemotype-aware ML train/test splits. Use when identifying chemotype clusters in a library, deriving SAR transformation rules, decomposing series into R-groups, performing scaffold-balanced QSAR splits, or planning analog campaigns.
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Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Filters AI-docking outputs (DiffDock, EquiBind, NeuralPLexer) where ~50% of poses fail physical-validity tests. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.
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Audit a GTK4/libadwaita app for GNOME HIG compliance across 12 categories (text, icons, layout, shortcuts, accessibility, color, dialogs, responsiveness, CSS, GSettings, i18n), then fix violations category by category. Use when asked to audit, review, polish, or "make HIG-compliant" a GNOME app, or before a release/Flathub submission.
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Package a GNOME app as a Flatpak — manifest for the GNOME runtime, sandbox permissions, build/run/test loop, and Flathub submission checklist. Use when packaging, distributing, or preparing a GNOME app for Flathub.
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Authoritative resource for building, auditing, and improving GNOME GTK4/libadwaita apps. Design tokens, 42-widget component library, 21 pattern skills, 47 mirrored HIG pages, 34 real-app audits, and lint scripts. Use when building a GNOME app, adding GNOME GUI features, auditing HIG compliance, packaging for Flatpak/Flathub, or when the user mentions GTK, libadwaita, Adw, Blueprint, or GNOME HIG.
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Make a GTK4/libadwaita app accessible — accessible labels and roles, tooltips on icon-only buttons, keyboard navigation, contrast, and testing with Orca/Accerciser. Use when fixing a11y issues or running the accessibility category of a HIG audit.
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Completes the online SBTI personality test at sbti.fancc.de5.net, answers all single-choice questions using the model's default personality and stable behavioral tendencies, submits the test, and returns the final type, match percentage, result description, and fifteen-dimension scores. Use when the user asks to take the SBTI test, run the SBTI quiz, get an SBTI result, or complete that personality test website for them.
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Use every time you push a commit to an active pull request, to verify the PR is truly stable before reporting merge readiness. Covers the post-push wait window, AI review audit (Copilot/Greptile/Codex), and the gh commands to snapshot PR state. Trigger on "I pushed" or "is the PR ready to merge".
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Two-phase memory hygiene. Phase 1: scan external Claude Code memory (~/.claude/projects/<slug>/memory/) for durable rules to migrate into the repo and entries already duplicated by repo atoms. Phase 2: audit in-repo memory/, CLAUDE.md, docs/architecture/, and docs/sections/ for dead links, duplication, drift, and bloat.
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Promote QA → production by opening a PR from peterdrier/Humans:main to nobodies-collective/Humans:main with a properly-qualified commit summary. Use when the user says "PR to production", "promote to prod", "PR from origin to upstream", "prod PR", or any variation of pushing batched fork changes upstream. Always use this skill for the two-remote promotion flow even if the user doesn't say "prod" explicitly.
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Run browser-based smoke tests against the running Humans site using the Claude Code Chrome extension. Argument: all | smoke | auth | profile | consent | teams | admin | gdpr | i18n | [url]
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Three-axis orchestrator: (1) clean section boundaries — naming, routes, views, ViewModels, DB ownership, cross-section access; (2) internal cohesion — no EF in service layer, caching in service only, proper interfaces, reusable ViewComponents, architecture-test coverage; (3) focused tests — grouped under the section, covering invariants/negatives/triggers, pruned of redundancy. Push-and-bot-review loop. Use when a sizable PR landed, a section shows arch drift, or /pr-review returned a non-trivial violation list. Camps is the gold-standard reference.
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Audit site navigation — find dead-end features, missing backlinks, and poor discoverability. Produces an improvement list, no code changes.
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Stryker-driven test cull: delete slop, consolidate redundants, fill mutation-coverage gaps. Score up, test count and lines down. Use when the user says 'trim tests', '/trim-tests', or wants to clean up LLM-generated test bloat. No args picks the worst-scored file; argument scopes to a section, service, or file.
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Autonomous themed tech-debt cleanup. Reads docs/architecture/debt-ledger.yml, rotates to the least-recently-served debt theme, works it for a time budget (default 2h) or until drained, opens one PR, and asks judgment questions inline at the end. Use for daily debt burndown without Peter pointing at a target: grandfathered analyzer rules, architecture-test baselines, obsolete-field reads, cross-section stitching.
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Pre-PR verification for VenTu — tests, data validation, static build, and e2e for the touched surface. Use before opening any PR. For visual UI checks also load ventu-verify-ui.
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Build an animation from scratch, making the decisions in the order that determines whether it feels right — should it animate at all, what purpose, which tool, which properties, which curve and duration, how it interrupts, how it exits. Writes the implementation. Use when asked to animate something, add motion, make a component feel alive, or build a transition. For critiquing existing motion use review-animations; for auditing a whole codebase use improve-animations.
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Survey a codebase's animation and motion code as a senior motion advisor, then produce a prioritized audit and self-contained implementation plans for other agents (or cheaper models) to execute. Read-only on source code — it plans improvements, it does not apply them. Use when the user asks to "improve the animations", "audit the motion", "make this app feel better", or wants a roadmap of animation fixes rather than a review of a single diff.
日本語の概要は準備中です。原文の説明を表示しています。