Design skills

Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Colic et al. 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving greater sensitivity to small-effect hits than MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).

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Designs covalent inhibitors and warheads targeting cysteine, lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.

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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Performs retrosynthetic planning using AiZynthFinder (template-based MCTS), maintained or version-pinned template-free models, ASKCOS, and emerging RetroSynFormer with explicit handling of route scoring, configurable MCTS rewards, building-block availability, and forward-prediction checks. Use when assessing synthetic feasibility of generated or selected molecules, planning multi-step syntheses, building synthesis-aware design pipelines, or screening libraries for retro-route feasibility.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

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Design and build a high-converting questionnaire-style onboarding flow for your app, modelled on proven conversion patterns from top subscription apps.

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Review TDesign Flutter 组件的公开 Demo、API 收敛、Flutter 设计模式、主题、测试和 Golden 证据。以小程序公开 Demo 作为可见效果参考，但不机械映射其 props/events；适用于组件对齐和 PR Review。

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TDesign Flutter 通用协作约定，适用于仓库开发和 PR 工作，涵盖 Spec、更新日志、公开契约、生成产物、双版本及 CI 登记。组件对齐由 Review skill 补充，CNB 平台限制见仓库协作说明。

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Design, validate, and plan a startup from scratch. Covers market research, competitive analysis, business model, brand identity, product definition, financial projections, and validation experiments. Trigger when the user has a startup idea to explore, wants to validate a business concept, needs a business plan or lean canvas, asks for market sizing or competitive landscape, wants brand positioning or go-to-market strategy, or says anything like "I have an idea for..." or "is this idea worth pursuing". Also handles resuming from a previous checkpoint.

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Build investor-ready pitch scripts in multiple formats (10-min, 5-min, 2-min, 1-min elevator, investor email). Produces pitch narratives, Q&A preparation, pitch scoring rubric, and optional investor roleplay practice. Use when the user wants to create a pitch, prepare for investor meetings, craft a startup pitch, write a fundraising narrative, or practice their pitch. Triggers for "pitch deck", "investor pitch", "pitch my startup", "fundraising deck", "seed deck", "how to pitch", "investor meeting", "demo day", "prepare pitch", "pitch script", "elevator pitch for investors", "pitch practice", "practice my pitch", "investor roleplay", or any request to present a startup to investors, accelerators, or partners. Works standalone — no prior startup-design session needed, but leverages its output if available.

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Design and validate digital filters in MATLAB. Use when cleaning up noisy signals, removing interference, filtering signals, designing FIR/IIR filters (lowpass/highpass/bandpass/bandstop/notch), or comparing filters in Filter Analyzer.

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Cascade PCB components, add lumped elements, export Touchstone, and bridge to eye diagram or antenna array workflows. TRIGGER: user asks to cascade or connect multiple RF PCB components, add lumped R/L/C, export S-parameters to Touchstone, or combine PCB elements into a circuit. Invoke BEFORE writing pcbcascade or circuit code — cascade rules and port matching are non-obvious. SKIP: designing individual components (use the specific matlab-design-pcb-* skill), EM analysis of a single component (use matlab-analyze-em), material/stackup setup only (use matlab-manage-pcb-material), optimization (use matlab-optimize-pcb-design).

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Spiral inductors, interdigital capacitors, baluns, resonators, phase shifters for impedance matching, DC blocking, and bias tees. TRIGGER: user asks to design or create a spiral inductor, interdigital capacitor, balun, resonator, phase shifter, or other passive RF component. Invoke BEFORE writing code — class names and property patterns are non-obvious. SKIP: filter design (use matlab-design-pcb-filter), coupler/splitter design (use matlab-design-pcb-coupler), transmission line design (use matlab-design-pcb-transmission-line), EM analysis (use matlab-analyze-em), material setup only (use matlab-manage-pcb-material).

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Wilkinson, branchline, ratrace, directional couplers, corporate dividers, Rotman lenses for power splitting and beam-forming. TRIGGER: user asks to design, create, or analyze any coupler, splitter, power divider, combiner, or Rotman lens. Invoke BEFORE writing code — class names and design() availability vary per coupler type. SKIP: EM simulation/S-parameter extraction of an existing component (use matlab-analyze-em), building custom non-catalog geometry (use matlab-assemble-pcb-layout), material/stackup setup only (use matlab-manage-pcb-material), cascading multiple components (use matlab-integrate-pcb-circuit).

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Microstrip, stripline, CPW, differential pairs, and crosstalk analysis for impedance-controlled PCB interconnects. TRIGGER: user asks to design or analyze a transmission line (microstrip, stripline, CPW, coplanar, differential pair), extract RLGC or per-unit-length parameters, compute trace impedance, analyze a PCB trace cross-section, or perform crosstalk/coupling analysis. Invoke BEFORE writing code — preferred over RF Toolbox analytical functions (txlineMicrostrip, txlineStripline, txlineCPW). SKIP: EM simulation/S-parameter extraction of an existing component (use matlab-analyze-em), material/stackup definition only (use matlab-manage-pcb-material), building custom non-catalog geometry (use matlab-assemble-pcb-layout), optimization sweeps (use matlab-optimize-pcb-design).

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Integrate antennas into RF systems using MATLAB Antenna Toolbox and RF Toolbox. Covers impedance matching network design (L/Pi/Tee topologies, evaluation parameters, Richards transformation), measured antenna creation (E-field, directivity-only, EmbeddedE, ffsReader import), RF propagation and site planning (txsite/rxsite, coverage, SINR, ray tracing, link budget), and SAR estimation (birdcage+Phantom, conformalArray+Custom3D, direct EHfields). Use when the user wants to match an antenna, create a measuredAntenna, compute coverage or signal strength, perform ray tracing, or estimate SAR.

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Bandpass, lowpass, bandstop filter design — hairpin, coupled-line, combline, stub, SIW for frequency selection and harmonic rejection. TRIGGER: user asks to design, create, or analyze any RF filter (bandpass, lowpass, highpass, bandstop, hairpin, coupled-line, combline, stub, SIW). Invoke BEFORE writing code — filter class names differ from what you would guess. SKIP: EM simulation/S-parameter extraction of an existing filter (use matlab-analyze-em), general PCB layout assembly (use matlab-assemble-pcb-layout), material/stackup setup only (use matlab-manage-pcb-material), optimization sweeps (use matlab-optimize-pcb-design).

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Design and implement adaptive filters using DSP System Toolbox System objects. Use when working with adaptive filtering, system identification, noise cancellation, echo cancellation, active noise control (ANC), channel equalization, inverse system identification, or adaptive prediction. Covers dsp.LMSFilter, dsp.RLSFilter, dsp.FilteredXLMSFilter, dsp.FrequencyDomainAdaptiveFilter, dsp.AffineProjectionFilter, dsp.BlockLMSFilter, dsp.AdaptiveLatticeFilter, dsp.FastTransversalFilter, maxstep(), and algorithm selection for adaptive filtering problems. Replaces deprecated adaptfilt.* objects (removed R2020a).

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Dielectric substrates, metal conductors, multi-layer stackups, and loss models (FR4, Rogers, Teflon) for RF PCB simulation. TRIGGER: user asks to set up a substrate, define dielectric properties, create a stackup, select a PCB material (FR4, Rogers, Teflon, etc.), or configure metal conductors. Invoke BEFORE writing dielectric() or metal() code — the API for named vs custom materials differs significantly. SKIP: PCB layout assembly (use matlab-assemble-pcb-layout), transmission line design (use matlab-design-pcb-transmission-line), EM analysis (use matlab-analyze-em), importing a PCB file (use matlab-read-pcb-layout).

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Optimize RF PCB dimensions for bandwidth, return loss, or area via patternsearch and surrogateopt with constraints. TRIGGER: user asks to optimize an RF PCB component for performance (bandwidth, return loss, insertion loss, area) or apply constraints to a design. Invoke BEFORE writing optimization code — RF PCB Toolbox has a built-in optimize() function that differs from generic fmincon/ga approaches. SKIP: designing a component from scratch without an optimization objective (use the specific matlab-design-pcb-* skill), EM analysis without optimization (use matlab-analyze-em), material/stackup setup only (use matlab-manage-pcb-material).

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Export pcbComponent designs to Gerber files with RF connectors and fab service formatting for PCB manufacturing. TRIGGER: user asks to export a PCB design to Gerber, generate manufacturing files, or write out a pcbComponent for fabrication. Invoke BEFORE writing export code — gerberWrite signature (pcbComponent, connectors, filename) is non-obvious. SKIP: importing/reading PCB files (use matlab-read-pcb-layout), building PCB geometry (use matlab-assemble-pcb-layout), EM analysis (use matlab-analyze-em), material/stackup setup (use matlab-manage-pcb-material).

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Model a Phase-Locked Loop (PLL) IC from its datasheet or system specs using Mixed-Signal Blockset. Without this skill, agents universally select the wrong solver and produce non-functional PLL models — 100% of unguided attempts fail. Covers Integer-N, Fractional-N, Dual Modulus architectures, loop filter design, lock time optimization, VCO phase noise configuration, and msbPllArchitectures/msbPllFoundation block assembly. Use when: PLL modeling, frequency synthesizer design, phase noise simulation, lock time analysis, charge pump design, loop filter tuning, datasheet-to-model, Mixed-Signal Blockset PLL, msbPllArchitectures.

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Use when designing a Digital Down Converter (DDC) using dsphdl System objects. Triggers on requests involving DDC design, frequency down-conversion for FPGA/ASIC, NCO + mixer + decimation filter chains, fractional/non-integer sample rate conversion, or HDL-optimized receiver front-end signal processing.

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