Writing & Fiction skills

Look up information about a person - work history, social profiles, contact info

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Find company funding history, investors, and investment details

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Reduce defensive writing in drafts and revisions by removing unnecessary caveats, disclaimers, hedges, apology-like framing, negative self-limiting statements, and over-explanations while preserving necessary scope, accuracy, safety, legal, ethical, and methodological limits. Use when drafting or revising academic writing, papers, essays, abstracts, introductions, contribution statements, discussions, conclusions, technical explanations, grant writing, product writing, policy writing, professional reports, or any text the user wants to be clearer, stronger, more direct, more concise, more confident, less verbose, less caveated, less apologetic, or less defensive.

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Discovers, classifies, filters, and quantifies full-length transcript isoforms from PacBio Iso-Seq/Kinnex (HiFi) and Oxford Nanopore (cDNA/direct-RNA) long reads, using the isoseq+pigeon pipeline, SQANTI3, and ONT tools (IsoQuant, FLAIR, Bambu, StringTie2). Covers why a novel isoform is an artifact until proven otherwise (RT template-switching, intra-priming, and 5' degradation manufacture junctions and truncations), the SQANTI3 structural categories and their trust order, the Kinnex skera-split step, orthogonal CAGE/poly-A/short-read-junction validation, and why long-read isoform quantification needs EM. Use when building a full-length isoform catalog, classifying/filtering long-read transcripts, running Iso-Seq or ONT cDNA/dRNA analysis, or judging novel-isoform reliability.

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Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.

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Tests genotype-environment associations and identifies adaptive loci while correcting for the four-confound landscape (structure, demography, background selection, sampling design) using LFMM2 with mandatory K via sNMF cross-entropy elbow (LEA 3), BayPass Core/AUX/C2/IS with Omega covariance matrix, RDA / pRDA for polygenic adaptation (Forester 2018; requires imputed genotypes), OutFLANK with trimmed FST null, pcadapt, gradient forests (Ellis-Smith-Pitcher 2012, NOT mis-cited Ellis-Manel), Capblancq & Forester 2021 RDA Swiss-army-knife, genomic-offset prediction with Lind & Lotterhos 2025 three-regime caveat, Lotterhos-Whitlock sampling optima, Wang & Bradburd 2014 IBD vs IBE, and Circuitscape + ResistanceGA. Use when identifying adaptive loci across gradients, choosing K for LFMM2, deciding among GEA methods, predicting maladaptation with the novel-environment caveat, distinguishing IBD vs IBE, or optimizing sampling design.

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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

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Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3 (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.

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Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + SpliceAI context-aware), strandedness verification, GENCODE basic vs comprehensive choice, and rRNA contamination screening. Splicing analysis is more demanding than DGE on read length, depth, library prep, alignment strategy, and annotation choice — failures silently bias PSI estimates and inflate novel-junction false positives. Use when evaluating data suitability for splicing analysis, troubleshooting low event detection, or designing sequencing experiments where AS is a primary endpoint.

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Use when capturing or analyzing an iOS .memgraph, especially when the task mentions a memory leak, heap growth, persistent memory increase, ownership path, or matched-capture comparison with Apple CLI tools. Covers unambiguous Simulator capture, leaks/heap/vmmap/malloc_history evidence, raw artifact preservation, and same-flow verification. Use debugging-instruments for interactive Xcode Memory Graph, Instruments, generic retain-cycle inspection, or LLDB work.

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Shopify/DTC product differentiation strategy tool. Analyze competitor stores, extract pain points from reviews, identify brand positioning opportunities, and generate actionable differentiation strategies. Includes DTC-specific metrics like CAC, LTV, and brand story analysis. No API key required.

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Shop branding — banner design, logo, brand story, cohesive listing photography, packaging

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Automatically creates user-facing changelogs from git commits by analyzing commit history, categorizing changes, and transforming technical commits into clear, customer-friendly release notes. Turns hours of manual changelog writing into minutes of automated generation.

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Use on passages a search just returned (memory, vault, session history, wiki, web) before reading them in. Jev ranks them, drops the irrelevant, and flags prompt injection hidden in the text.

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Reach into past AI conversation history through the `trellis mem` CLI. Use whenever the user asks 'how did we solve X last time', 'have we discussed this before', 'what was the decision on X', 'remind me what we did in this task', '上次怎么解的', '之前讨论过吗', '想起一段对话', or when starting a brainstorm that overlaps prior work, debugging a familiar bug, continuing a task across sessions, or doing a finish-work review. Returns raw past dialogue; decide for the moment whether to update spec, append to task notes, quote inline in the answer, or just internalize.

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Use when the operator wants to write a blog post, draft a blog article, start a new post for the Prisma blog, or publish to prisma.io/blog.

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Draft from the vault: outline from concept pages, keep citations to the user's own sources, and surface where their material disagrees. Use this skill when the user wants to write an article, post, essay or newsletter based on what they have collected, or asks what they could write about a topic. Do NOT use for research reports, for writing with no grounding in the vault, or for editing text the user wrote themselves unless asked.

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Audit the vault for material that should not be in it: credentials, other people's private information, confidential work, and anything the user would not want synced or backed up. Use this skill when the user asks about privacy, is about to share or sync the vault, has just imported chat history or meeting notes, or asks what is sensitive in their notes. Do NOT use to delete anything on your own, or as a substitute for the publishing check.

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Import a large archive into the vault in controlled batches: triage what is worth ingesting, process oldest first, checkpoint after every batch, and keep cost visible. Use this skill whenever the user wants to import years of bookmarks, an export from another notes app, a downloads folder, a chat history dump, or says "backfill", "bulk import", "process my archive". Do NOT use for ingesting one or a few new sources, which is second-brain-ingest.

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Triage an exported chat history into what to ingest, what to archive and what to delete, with a privacy pass first. Use this skill when the user has exported their Claude or ChatGPT history, asks to import old conversations, or asks what in their chat archive is worth keeping. Do NOT use for ingesting a single pasted conversation, or for any material the user has not explicitly asked to bring into the vault.

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Find evidence-backed potential first customers, beta users, or design partners from public demand signals. Use for product-specific prospect research, qualified shortlists, source-grounded outreach drafts, and follow-up searches refined by the user's feedback and local prospect history. Does not send outreach automatically.

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Inspect CCAM dashboard-run history and relate live run handles to persisted Claude Code or Codex sessions. Use when finding a prior launched task, checking whether a run is still attached, reviewing start/end status, or deciding whether to resume, view, or relaunch work.

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Configure and validate CCAM webhook targets across supported chat, incident, automation, and generic providers. Use when listing provider requirements, creating or updating a target, scoping it to alert rules, sending a test notification, reviewing delivery history, or deleting a target.

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Detect quality and efficiency regressions over time using Agent Monitor data — rising error rate (APIError events), falling cache hit rate, growing compaction frequency, and climbing cost-per-session. Splits history into an earlier baseline window and a recent window and reports which metrics are getting worse, by how much, and where. Use when checking whether things are degrading or trending in the wrong direction.

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