Browse skills

Fit probabilistic models to single-cell measurements for integration across experiments, cell annotation, combined RNA and protein or ATAC analysis, and gene expression comparisons. The skill covers input requirements, training checks, reference mapping, and interpretation of model uncertainty.

• Integrating single-cell RNA data across experimental batches
• Assigning cell labels using partial annotations or a reference
• Analyzing RNA with protein or ATAC measurements

Estimate RNA velocity, the modeled direction of gene expression change, from single-cell spliced and unspliced counts. Fit models, inspect gene-level plots, visualize trajectories, and explore relative timing and associated genes while checking model limitations.

• Explore hypotheses about directions of cell-state change
• Inspect gene-level RNA velocity model fits
• Estimate relative cell ordering with a dynamical model

Simulate concentration changes over time from biochemical models in SBML or Antimony, and compare fixed parameter conditions. Checks model units and exports CSV results plus COMBINE archives containing models and experiment settings, then replays them to compare results.

• Calculate concentration changes in reaction networks
• Compare baseline and altered kinetic parameters
• Inspect model units and consistency warnings

Forecast sales and other time series with Google’s TimesFM without task-specific training. Prepare regularly spaced CSV data, export predicted values and uncertainty ranges, add explanatory variables, and evaluate forecasts against held-out observations.

• Forecast monthly sales or revenue from CSV data
• Export predicted values with uncertainty ranges
• Forecast with additional explanatory variables

Build and test SimPy models of queues, production, logistics, and other event-driven systems. Set execution limits, monitor waiting times and resource use, and analyze repeated runs with recorded random seeds for reproducible results.

• Comparing waiting times with different staffing levels
• Modeling shared equipment in production or logistics
• Testing priority queues and interrupted work

Build and evaluate time-to-event models with scikit-survival, including records whose events remain unobserved when follow-up ends. Keep preprocessing separate from evaluation data, compare models, predict survival probabilities, and summarize censoring-aware metrics.

• Validate event indicators and follow-up times in local CSV data
• Train survival models without leaking evaluation data
• Evaluate survival probabilities with censoring-aware metrics

Check physical units, propagate measurement uncertainty through calculations, and format results with meaningful precision. Local tools also inspect Python code for unit and uncertainty mistakes and assess whether calculated magnitudes are physically plausible.

• Convert units while carrying measurement uncertainty
• Build an uncertainty budget from calibration data
• Audit Python calculations for unit and uncertainty errors

Work with large scientific arrays by storing data in smaller blocks and reading selected portions. Guides compression, cloud storage, format migration, and NumPy, Dask, or Xarray integration while preserving dimensions, units, and other metadata.

• Reading selected regions of large scientific arrays
• Choosing data blocks and compression settings
• Working with scientific arrays stored on S3 or GCS

Reduce data with many features into fewer dimensions using UMAP. Create 2D or 3D views, prepare inputs for clustering, compare parameter settings, and project new samples while checking whether the results remain stable and meaningful.

• Visualizing data with many features in 2D or 3D
• Preparing reduced features for HDBSCAN clustering
• Guiding dimensionality reduction with partial labels

Prepare papers, research posters, and grant documents for a specific journal, conference, or funder. The skill guides official template selection, checks current submission requirements, adapts writing, and inspects PDF page counts and embedded fonts.

• Preparing a paper for a journal or conference
• Checking page limits and anonymous review requirements
• Drafting grant proposal components

Analyze large scientific tables with Vaex, including datasets that exceed available memory. Build calculated columns, filter rows, compute statistics, visualize aggregated data, and convert files while identifying operations that may still require substantial RAM.

• Computing statistics on tables larger than available memory
• Creating calculated features without storing full columns
• Visualizing large datasets with aggregated grids

Retrieve U.S. federal financial data from the Treasury’s public API, including debt, revenue, spending, interest rates, and exchange rates. Filter dates and fields, retrieve multiple pages, and organize results into tables for analysis.

• Tracking U.S. national debt over time
• Comparing monthly federal revenue and spending
• Retrieving Treasury reporting exchange rates

Create static statistical charts from pandas tables to explore distributions, relationships, and group differences. Supports scatter plots, regression displays, pair plots, and heatmaps, with explicit choices for aggregation, uncertainty, missing data, and visual styling.

• Exploring distributions and relationships in tabular data
• Comparing group differences with box or violin plots
• Visualizing correlation matrices as heatmaps

Analyze experimental or survey data with guidance on choosing statistical tests, checking assumptions, estimating effect sizes and uncertainty, planning sample sizes, and writing results in APA style, a standard format for research reporting.

• Comparing outcomes between experimental groups
• Examining relationships in survey data
• Planning the number of study participants

Use SymPy to simplify expressions, solve equations, and calculate derivatives, integrals, and matrices with exact symbolic results. Specify assumptions, verify solutions, and turn mathematical expressions into numerical functions, source code, or LaTeX output.

• Solving equations and checking their solutions
• Calculating symbolic derivatives, integrals, and limits
• Finding matrix eigenvalues with exact arithmetic

Organize treatment decisions already supplied and verified by authorized licensed professionals into local JSON documents. Check document structure, source references, declared review status, and supplied dates to support documentation handoffs without making clinical decisions.

• Organize verified clinician-authored treatment records
• Check source references and missing documentation fields
• List checkpoint dates already supplied by clinicians

Stress-test research plans by comparing possible scenarios, such as sample losses, unavailable materials, or methods failing to transfer. Record assumptions and evidence, compare response options, and define contingency plans and observable triggers for changing course.

• Plan responses to higher-than-expected sample losses
• Prepare backups for unavailable reagents or datasets
• Compare research options under resource constraints

Fit regression and time series models in Python, interpret coefficients, compare alternatives, and check model assumptions. Supports statistical diagnostics and forecasting, with confidence intervals and validation steps to assess uncertainty and predictive performance.

• Fit regression models and interpret coefficients
• Compare models for binary outcomes or counts
• Forecast time series with prediction intervals

Plan study sample sizes, estimate statistical power—the chance of detecting an assumed effect—and find the smallest detectable effect. Supports standard tests and simulations for complex designs, with sensitivity analyses and sample size justifications.

• Estimating participant or sample counts before data collection
• Finding the smallest effect detectable with a fixed sample
• Preparing sample size justifications for grants or protocols

Work with Waypoint models to analyze microbiome samples, the communities of microbes in a sample. Convert taxonomic abundance tables, generate numerical sample representations, configure further training for prediction tasks, and evaluate models on the Compass benchmark.

• Convert microbiome abundance tables into Waypoint inputs
• Generate sample vectors for clustering and visualization
• Configure further training with sample labels

Build and troubleshoot TorchDrug 0.2.1 workflows for molecular property prediction, molecule generation, protein modeling, and knowledge graph reasoning. Connect datasets, models, training tasks, and evaluation while checking version compatibility and common implementation errors.

• Training and evaluating molecular property prediction models
• Building molecule generation workflows
• Learning representations of protein sequences and structures

Store genomic variant records in TileDB-VCF, add samples over time, and retrieve selected samples or genomic regions. Supports batch reading, allele statistics, quality checks, and VCF/BCF export, with workflows for local storage and TileDB Cloud.

• Build a variant dataset and add samples incrementally
• Extract variants for selected samples and genomic regions
• Review allele statistics and sample quality

Use Hugging Face Transformers to load pretrained models, generate text, and classify text, images, or audio. Prepare model inputs, control generation settings, and fine-tune models on custom datasets with the Trainer API.

• Prototype text, image, or audio classification
• Configure text generation and conversational responses
• Fine-tune a model on a custom dataset

Build and evaluate single-agent reinforcement learning experiments, where an agent learns actions from rewards. Use Stable Baselines3 to choose algorithms, create environments, monitor training, and save models with the normalization data needed for consistent evaluation.

• Set up a reproducible reinforcement learning experiment
• Create and validate a custom Gymnasium environment
• Monitor training and save checkpoints