Results for “stability”

Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), MSIngs, MANTIS, MSIPanel, MSIDetect, and ngsMSI for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.

The English summary is being prepared. Showing the original description.

Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.

The English summary is being prepared. Showing the original description.

Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

The English summary is being prepared. Showing the original description.

Expert in ALL computational collage composition: photo mosaics, grid layouts, scrapbook/journal styles, magazine editorial, vision boards, mood boards, social media collages, memory walls, abstract/generative arrangements, and art-historical techniques (Hockney joiners, Dadaist photomontage, Surrealist assemblage, Rauschenberg combines). Masters edge-based assembly, Poisson blending, optimal transport color harmonization, and aesthetic optimization. Activate on 'collage', 'photo mosaic', 'grid layout', 'scrapbook', 'vision board', 'mood board', 'photo wall', 'magazine layout', 'Hockney', 'joiner', 'photomontage'. NOT for simple image editing (use native-app-designer), generating new images (use Stability AI), single photo enhancement (use photo-composition-critic), or basic image similarity search (use clip-aware-embeddings).

The English summary is being prepared. Showing the original description.

Detects test antipatterns and code smells in PHP test suites. Identifies 15 smells (Logic in Test, Mock Overuse, Fragile Tests, Mystery Guest, etc.) with fix recommendations and refactoring patterns for testability.

The English summary is being prepared. Showing the original description.

Analyzes coupling and cohesion metrics in PHP codebases. Calculates Afferent/Efferent coupling (Ca/Ce), LCOM metrics, instability index, and abstractness. Identifies highly coupled modules and low cohesion classes.

The English summary is being prepared. Showing the original description.

Expert security auditor for AI Skills and Bundles. Performs non-intrusive static analysis to identify malicious patterns, data leaks, system stability risks, and obfuscated payloads across Windows, macOS, Linux/Unix, and Mobile (Android/iOS).

The English summary is being prepared. Showing the original description.

Google SRE (Site Reliability Engineering) practices distilled from the SRE book series and real Google Brain/Meta/ByteDance production experience. Covers SLI/SLO/Error Budget design, incident response, capacity planning, toil automation, monitoring golden signals, and chaos engineering principles. USE WHEN: designing reliability targets, setting up monitoring/alerting, planning capacity, reducing operational load, building incident response runbooks, implementing chaos engineering, defining error budgets, or establishing reliability culture that balances velocity with stability.

The English summary is being prepared. Showing the original description.

Self-healing stability monitor for AI agents - 5 core checks + 15 extended checks, auto-recovery, health scoring

The English summary is being prepared. Showing the original description.

Surface architectural friction and propose deepening opportunities that improve testability and AI-navigability. Use when the user wants to improve architecture, find refactoring opportunities, consolidate tightly-coupled modules, or make a codebase easier for agents to navigate.

The English summary is being prepared. Showing the original description.

Complete guide for .NET Aspire Testing integration testing framework. Use when testing .NET Aspire distributed applications, configuring AppHost tests, or migrating from Testcontainers to Aspire testing. Covers DistributedApplicationTestingBuilder, container lifecycle management, multi-service orchestration, Respawn configuration, and time testability design. Keywords: aspire testing, .NET Aspire, DistributedApplicationTestingBuilder, AppHost testing, distributed testing, AspireAppFixture, IAsyncLifetime, ContainerLifetime.Session, cloud-native testing, multi-service integration, Aspire.Hosting.Testing, Respawn

The English summary is being prepared. Showing the original description.

Generate or materially revise a repository-local test plan, QA plan, acceptance matrix, or regression checklist on explicit request or when one concrete testability gap blocks formal DEFINE; do not trigger for ordinary implementation, test execution, TDD, review, or completion claims.

The English summary is being prepared. Showing the original description.

Refactors route handlers into service layer with clean boundaries, dependency injection, testability, and separation of concerns. Provides service interfaces, folder structure, testing strategy, and migration plan. Use when refactoring "fat controllers", "business logic", "service layer", or "architecture cleanup".

The English summary is being prepared. Showing the original description.

Compares old vs new prompts across test cases with diff summaries, stability metrics, breakage analysis, and fix suggestions. Use for "prompt testing", "A/B testing prompts", "prompt versioning", or "quality regression".

The English summary is being prepared. Showing the original description.

Diagnoses and fixes flaky tests by identifying root causes (timing issues, shared state, randomness, network dependencies) and provides stabilization strategies. Use for "flaky tests", "test stability", "intermittent failures", or "test debugging".

The English summary is being prepared. Showing the original description.