Results for “models”

Discovers de novo motifs and tests known motif enrichment in ChIP-seq, ATAC-seq, or other peak sequences using HOMER, MEME-ChIP (STREME, CentriMo, TOMTOM, FIMO), monaLisa, and AME. Handles background selection (GC-matched, dinucleotide-shuffled, Markov order-2, peak-flanks), motif databases (JASPAR 2024 CORE PWMs, JASPAR 2026 deep-learning collection, HOCOMOCO v12, HOMER built-in), centrally-enriched motif testing, and differential motif analysis. Use when identifying TF binding motifs in peaks, testing for known TF enrichment, scanning for motif instances, comparing motif content between conditions, or interpreting motifs from deep learning models.

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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

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Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

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Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or EnFormer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.

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Use this skill when the user asks how to pay CDL drivers — cents per mile (CPM), percentage of revenue, hourly, salary, sleeper-team rate, detention pay, driver-pay laws under FLSA (Fair Labor Standards Act), and how each model affects retention + recruitment. Cite FLSA + state wage laws.

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Apply recognition-primed decision making to agents operating under time pressure, uncertainty, and ambiguous cues. Use for situation assessment, RPD-style action selection, and decision-support design in operational settings. NOT for batch optimization, static planning with full information, or tasks where exhaustive search is cheap and harmless.

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Apply recognition-primed decision making to agents operating under time pressure, uncertainty, and ambiguous cues. Use for situation assessment, RPD-style action selection, and decision-support design in operational settings. NOT for batch optimization, static planning with full information, or tasks where exhaustive search is cheap and harmless.

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Threat-models protocols where authority, scarce resources, bonds, bounties, escrow, reputation, ordering, adjudication, or settlement create strategic incentives. Use to test attack utility, conservation, collusion, Sybil resistance, oracle capture, griefing, custody, liquidity, and residual risk. NOT for choosing payment or bond amounts without evidence, smart-contract code audit, legal or employment classification, DeFi trading, admitting workers, or settling claims.

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Build, debug, optimize, and deploy ComfyUI workflows for diffusion image, video, and audio generation. Activate on: ComfyUI workflow, ComfyUI custom node, ComfyUI API, ComfyUI Manager, KSampler, FLUX in ComfyUI, Wan 2.2 ComfyUI, Hunyuan video ComfyUI, LTX video ComfyUI, IPAdapter, ControlNet ComfyUI, Kijai wrapper, ComfyDeploy, RunComfy, ComfyUI security, GGUF quantization, TeaCache, Nunchaku, ACE-Step ComfyUI, F5-TTS ComfyUI, subgraphs ComfyUI. NOT for: A1111/Forge/Invoke (different UIs), training pipelines from scratch, non-diffusion ML models, or general image-API integrations (use generative-video-2026 / generative-music-audio / media-gen-deployment).

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Semantic image-text matching with CLIP and alternatives. Use for image search, zero-shot classification, similarity matching. NOT for counting objects, fine-grained classification (celebrities, car models), spatial reasoning, or compositional queries. Activate on "CLIP", "embeddings", "image similarity", "semantic search", "zero-shot classification", "image-text matching".

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Methodology for eliciting expert knowledge about cognitive processes, decisions, and mental models in complex tasks

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Designs and audits native-unit capacity reservation, serial admission, ambiguity holds, stop reserves, effect closure, and control-disjoint settlement handoff for consequential agent attempts. Use when scarce capacity must be conserved across retry, rework, resurrection, or compensation. NOT for scheduling work, choosing models, pricing unlike resources into one scalar, authorizing effects, grading work, paying workers, or asserting runtime containment.

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Tracks cumulative LLM costs across DAG execution and makes real-time decisions to stay within budget. Downgrades models, skips optional nodes, or stops early when cost exceeds thresholds. Use when managing execution budgets, analyzing cost breakdowns, or optimizing model routing for cost. Activate on "cost budget", "too expensive", "reduce cost", "cost optimization", "model downgrade", "budget exceeded". NOT for LLM model selection logic (use llm-router), pricing comparisons across providers, or billing/invoicing.

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Expert causal reasoning and mental model construction for diagnosis and prediction in complex domains

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Expert knowledge of Person data integration (PDL) in melosys-api. Use when: (1) Working with person data from PDL (Person Data Lake), (2) Understanding identity types (fnr, aktørID, NPID), (3) Working with addresses, family relations, or citizenship, (4) Debugging person data lookup issues, (5) Understanding the mapping between PDL and domain models.

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Expert knowledge of Employer/Employment integration (EREG/AAREG) in melosys-api. Use when: (1) Working with organization data from EREG (Enhetsregisteret), (2) Working with employment data from AAREG (Arbeidsforhold), (3) Understanding employer/organization lookup, (4) Debugging employer or employment issues, (5) Understanding the mapping between register data and domain models. Triggers: orgnummer, arbeidsforhold, EREG, AAREG, Enhetsregisteret, registeropplysninger, ansettelsesperiode, saksopplysning.

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Finds what changed in Claude — docs, release notes, changelogs, GitHub and community posts on Claude Code, claude.ai, Cowork, the API and models — and turns each change into adopt rows for your setup, plus a fit card for a new model or feature and a monthly bench of your skills against public skill and plugin repos (build, adopt or skip). Trigger on what changed since a date or version, a weekly sweep, features worth adopting, a feature that broke unannounced, a stale model table, what a new model or feature is good for, or how your skills compare with popular or little-known skill and plugin repos; or say scoutwright (sweep, since, watch, adopt, fit, bench, sources, refresh). Outside research is researchscribe's; applying a row, skillwright's; config, rigwright's; schedules, agentwright's; tier picks, promptwright's.

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Hands work to a local model served by LM Studio and verifies what comes back. Trigger to offload, delegate or batch work to a local, offline or on-device model; to queue unattended runs that keep only what passes; to ask which installed model fits a job or whether to switch; to size a task before delegating; when a local model returns nothing, repeats itself or drifts on a long list; when LM Studio shares the GPU with an image tool, or to free its hold; or say lmstudiorunner (audit, size, queue, run, status). Reads models from the live LM Studio API. Cloud model picks and prompt text are promptwright's; a schedule's guardrails agentwright's.

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Runs a session's fan-out — splits a large request into tiered, recoverable units, dispatches and reconciles them against the repo. Trigger when work needs many agents or spans many repos or files (rebuild, re-architect, sweep, migrate, 'do all of this'); when subagents would launch with no model or effort set; for the plan table (units, models, tokens, meters) before launch; to resume a unit that died or hit a usage limit; when units would share a repo; or say dispatchwright (plan, dispatch, resume, audit, refresh). Tiers come from its own table (scoutwright flags it stale); pacing, pacewright's; hooks, rigwright's; schedules, agentwright's.

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Writes, fixes and red-teams prompts — system prompts, templates, meta-prompts, agent or bot instructions — as copy-paste-ready artifacts, and picks the model tier for a prompt, task or plan's subtasks. Trigger to write, improve, debug or rewrite a prompt; which model should run this; a prompt that costs too many tokens, to cut with behavior held; or say promptwright (model, optimize — tune against test cases, slim, refresh). Not for a fan-out's units (dispatchwright), installed local models (lmstudiorunner), skills or their slim (skillwright), sourced comparisons (researchscribe), handoffs (handoffwright) or a pre-build interview (grillwright).

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Elite frontend image-direction skill for generating premium, conversion-aware website design references. CRITICAL OUTPUT RULE — generate ONE separate horizontal image FOR EVERY section. A landing page with 8 sections produces 8 images. Never compress multiple sections into one image. Enforces composition variety (not always left-text / right-image), background-image freedom, varied CTAs, varied hero scales (giant / mid / mini minimalist), narrative concept spine, second-read moments, and a single consistent palette across all images. Optimized for landing pages, marketing sites, and product comps that developers or coding models can accurately recreate.

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Build reactive, type-safe, production-grade backends. ALWAYS use this skill when the user asks to build, plan, design, or implement backend features, APIs, data models, server logic, database schemas, web apps, full stack apps, or mobile apps. This includes planning and architecture discussions.

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Generates Read Model/Projection for PHP 8.5. Creates optimized query models for CQRS read side with projections and denormalization. Includes unit tests.

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Generates Mermaid diagrams for technical documentation. Provides templates for flowcharts, sequence diagrams, class diagrams, ER diagrams, and C4 models.

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