Results for “framework”

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

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Use this skill when the user asks about driver discipline — when to coach vs warn vs suspend vs terminate, progressive discipline frameworks, at-will employment in trucking, documenting violations, separating "willful violation" from "human error," and how to handle a driver who refuses corrective action. Reference state employment law + ATA SMP.

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Use when a carrier needs to build an internal dispatcher training program, onboard new dispatchers, or certify dispatcher competency. Covers job description, required skills, training modules, certification frameworks (CDS, CTP), shadowing, evaluation, and career path.

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Use this skill when the user asks about cybersecurity for a trucking carrier — protecting ELD data, customer information, financial systems, EDI integrations, fleet telematics, ransomware risk, vendor / shipper data sharing, incident response, and FMCSA cyber-recommendations. Reference NIST + CISA cybersecurity frameworks.

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Decision-theoretic framework for agents embedded within the environments they model and act upon

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Frontend stack decisions, Cloudflare deployment patterns, component systems, and internal tools architecture. Use for framework selection, deployment strategy, design system bridging, shadcn setup. Activate on "frontend architecture", "tech stack", "Cloudflare Pages", "component library", "internal tools", "shadcn setup". NOT for writing CSS (use frontend-developer), design critique (use design-critic), or backend APIs.

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End-to-end form handling with react-hook-form, Zod schemas, validation patterns, error messaging, field arrays, and multi-step wizards. Use for complex forms, validation architecture, autosave, field dependencies. Activate on "form validation", "react-hook-form", "Zod", "form error", "multi-step form", "wizard". NOT for simple HTML forms, backend validation only, or non-React frameworks.

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Principled action selection for autonomous agents using Expected Free Energy (EFE) under the Active Inference framework. Each candidate action is scored as G(n) = w_prag * (-E[p_n] * damping) + w_epist * (-Var[p_n] * novelty(n)), where agent beliefs are maintained as per-node Beta distributions and updated via Bayesian observation. Selection is a softmax over -gamma * G, making exploration an automatic consequence of uncertainty rather than a hardcoded epsilon. Precision weights w_prag and w_epist self-adapt via surprise history, shifting the agent between exploitation and exploration regimes without any manually tuned schedule.

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Cloudflare Pages CI/CD with preview environments, edge functions, and Wrangler automation. Activate on: Cloudflare Pages, Wrangler deploy, preview environment, edge function, Pages project, Cloudflare Workers integration, custom domain on Pages. NOT for: Worker-specific development (use cloudflare-worker-dev), DNS management (use devops-automator), full-stack app frameworks (use vercel-deployment).

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Systematic framework for resurrecting and modernizing legacy codebases through archaeology, resurrection, and rejuvenation phases. Activate on "legacy code", "inherited codebase", "no documentation", "technical debt", "resurrect", "modernize". NOT for greenfield projects or well-documented active codebases.

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Choose, compare, and decompose work into the right coordination topology: dag, workflow, manager-driven team, swarm, blackboard, team-builder, or recurring loop. Use when the coordination shape is unclear, when you need topology-native breakdown instructions instead of a generic DAG, or when planning topology and runtime topology may differ. NOT for actual execution, node-level skill matching, or framework/tool installation.

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AWS CDK infrastructure builder using TypeScript with L2/L3 constructs and Well-Architected patterns. Activate on: AWS CDK, CDK construct, CDK stack, CDK pipeline, AWS infrastructure as code TypeScript, L2 construct, CDK patterns. NOT for: Terraform IaC (use terraform-module-builder), Kubernetes manifests (use kubernetes-manifest-generator), serverless framework (use devops-automator).

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Architecture and systems design for agents that retain bounded state across sessions. Covers durable event history, owned state, derived memory, retrieval indexes, framework evaluation, recovery, deletion, and rebuild behavior. Uses constructed implementation examples and workload calibration rather than universal vendor, latency, similarity, retention, or cost claims. Activate on: "always-on agent", "persistent agent architecture", "episodic memory system", "agent memory design", "long-running agent", "stateful agent", "agent that remembers", "MemGPT architecture", "Letta deployment", "/always-on-agent-architecture". NOT for: choosing what data to feed the agent (use always-on-agent-inputs), brainstorming applications (use always-on-agent-applications), safety and privacy concerns (use always-on-agent-safety), general agentic patterns (use agentic-patterns).

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Perform language and framework specific security best-practice reviews and suggest improvements. Use when the user explicitly requests security best practices guidance, a security review/report, or secure-by-default coding help. Trigger only for supported languages (python, javascript/typescript, go), and not for general debugging or non-security tasks.

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Detects leaky abstractions in PHP code. Identifies implementation details exposed in interfaces, concrete returns from abstract methods, framework leakage into domain, and infrastructure concerns in application layer.

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Implement REST APIs in ABP Framework with AppServices, DTOs, pagination, filtering, and authorization. Use when building API endpoints for ABP applications.

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ABP Framework application layer patterns including AppServices, DTOs, Mapperly mapping, Unit of Work, and common patterns like Filter DTOs and ResponseModel. Use when: (1) creating AppServices, (2) mapping DTOs with Mapperly, (3) implementing list filtering, (4) wrapping API responses.

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ABP Framework domain layer patterns including entities, aggregates, repositories, domain services, and data seeding. Use when: (1) creating entities with proper base classes, (2) implementing custom repositories, (3) writing domain services, (4) seeding data.

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ABP Framework cross-cutting patterns including authorization, background jobs, distributed events, multi-tenancy, and module configuration. Use when: (1) defining permissions, (2) creating background jobs, (3) publishing/handling distributed events, (4) configuring modules.

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Эксперт A/B тестирования. Используй для статистических тестов, экспериментов и ML-оптимизации.

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5W1H Decision Framework Tool. Use for: (1) Systematic decision-making before creating todos, (2) Preventing duplicate implementation, (3) Detecting avoidance behavior, (4) Ensuring agile refactor compliance with executor/dispatcher separation

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[02] META. Create new skills when existing ones don't cover the task. Analyze unique requirements, build framework (Frame → Research → Plan → Execute), integrate risks, and declare new skill. Use when facing novel problems that existing skills can't address.

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Develops iOS/iPhone applications with XcodeGen, SwiftUI, and SPM. Triggers on XcodeGen project.yml configuration, SPM dependency issues, device deployment problems, code signing errors, camera/AVFoundation capture debugging, iOS version compatibility, or "Library not loaded @rpath" framework errors. Use when building iOS apps, fixing Xcode build failures, or deploying to real devices. Not for AVPlayer playback issues (seek/scrub/frame stepping → avfoundation-reference skill).

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Codified expertise for handling freight exceptions, shipment delays, damages, losses, and carrier disputes. Informed by logistics professionals with 15+ years operational experience. Includes escalation protocols, carrier-specific behaviors, claims procedures, and judgment frameworks. Use when handling shipping exceptions, freight claims, delivery issues, or carrier disputes.

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