613 skills · sorted by relevance
Access European Nucleotide Archive via API/FTP. Retrieve DNA/RNA sequences, raw reads (FASTQ), genome assemblies by accession, for genomics and bioinformatics pipelines. Supports multiple formats.
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Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.
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Deliberate-choice procedure for a medium-to-high-stakes engineering fork — when the first plausible solution (the instinct, the default next-token pull) would be costly to get wrong. Fires AUTONOMOUSLY: invoke proactively whenever a fork fits, never wait to be asked — mechanical triggers include a fix failing for the 2nd-3rd time, adding a dependency, schema/migration design, deleting or deprecating things others depend on, changing a public API, choosing an architecture or stack. Refuse the premature collapse: hold real options open (urge · contrarian · synthesis · out-of-box · intuitive dots · precedent · first-principles), ground each branch in at least one fact from outside the model (codebase, docs, benchmark, spike), future-model consequences (blast radius, reversibility, maintenance, pre-mortem), collapse by deliberate choice, then try to refute the winner before acting. Log the decision and rejected branches in docs/decision_logs/. Not for routine calls — a decision worth more than one forward pass.
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Query UCSC Genome Browser REST API for DNA sequences, tracks, gene models, and conservation across 100+ assemblies. Retrieve sequence by region, list/fetch BED/bigWig tracks, chromosome sizes, RefSeq/GENCODE gene structures, PhyloP/PhastCons scores. Use for UCSC annotations; Ensembl REST API for Ensembl gene IDs and VEP variant annotation.
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ENA REST API for sequences, reads, assemblies, and annotations. Portal API search, Browser API retrieval (XML/FASTA/EMBL), file reports for FASTQ/BAM URLs, taxonomy, cross-refs. For multi-DB Python use bioservices; for NCBI-only use pubmed-database or Biopython Entrez.
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NCBI Gene via E-utilities: curated records across 1M+ taxa. Official symbols, aliases, RefSeq IDs, summaries, coordinates, GO, interactions. Use for gene ID resolution and cross-species function queries. For sequences use Ensembl; for expression use geo-database.
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Query RCSB PDB (200K+ structures) via the public REST + GraphQL APIs with plain `requests` (no SDK). Search by text, attribute, sequence, or 3D structure similarity (Search API); retrieve metadata via GraphQL (Data API); download PDB/mmCIF from files.rcsb.org. For AlphaFold predictions use alphafold-database-access; for protein sequences only use uniprot-protein-database.
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Protein language models (ESM3, ESM C) for sequence generation, structure prediction, inverse folding, and embeddings. Design novel proteins, extract ML features, or fold sequences. Local GPU or EvolutionaryScale Forge API. Use AlphaFold for traditional folding; RDKit for small molecules.
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Three-tiered sgRNA design guide using validated Addgene sequences, CRISPick pre-computed datasets, or de novo design rules for CRISPR experiments
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API + Python SDK for ordering cell-free protein expression and binding assays. Submit sequences for expression (10–100 µg), measure binding affinity (KD) against targets, track status, and retrieve results programmatically — no wet-lab setup. Built for ML-guided directed evolution and antibody/nanobody optimization. Requires Adaptyv account and API key.
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Search the PRIDE Archive v3 REST API for proteomics datasets: discover projects by keyword + faceted filters (organism, instrument, disease, software), fetch project metadata, list and download RAW/PEAK/RESULT/FASTA files (with FTP/Aspera URLs), look up which projects mention a UniProt accession, and find similar projects. PRIDE v3 no longer exposes peptide/PSM-level identification endpoints — for spectrum-level data download the project's RESULT files. Use uniprot-protein-database for protein sequences; interpro-database for domain architecture.
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Query InterPro REST API for protein domain architecture, family classification, and member-DB integration. Search entries, retrieve a protein's domains, list family members, get taxonomic distribution, link to PDB. Unifies Pfam, PANTHER, PIRSF, PRINTS, PROSITE, SMART, CDD, NCBIfam. Use uniprot-protein-database for sequences; pdb-database for 3D structures.
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When the user needs to design, write, or optimize email sequences -- including welcome series, nurture campaigns, re-engagement flows, onboarding emails, or newsletter strategy.
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When the user needs to plan or execute a product launch — including pre-launch content sequences, launch funnels, JV/affiliate launches, cart open/close strategy, or evergreen launch funnels.
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Transform webinar recordings into multiple content assets including blog post series, social media snippets, infographic ideas, email sequences, and sales one-pagers. Extracts key moments, quotes, and insights for maximum content ROI. Use when users need to repurpose webinars, video content, or live presentations into multi-channel marketing materials.
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Scene composition and orchestration skill for creating complex multi-part animations. **Triggers when:** - User wants to compose multi-element scenes - Request involves combining multiple visual elements - Scene requires act-based structure or transitions - User mentions "scene", "compose", "combine", "orchestrate" **Capabilities:** - Scene graph construction with acts and transitions - Multi-object coordination and timing - Camera movements and focus control - Layered animation sequences
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Plans, creates, and optimizes digital marketing campaigns including content strategy, social media, email marketing, SEO, and AI visibility (GEO). Generates UTM parameters and tracking URLs. Helps develop go-to-market strategies, campaign messaging, content calendars, and performance measurement frameworks. Use when asked to "create a marketing campaign", "plan content strategy", "build email sequences", "set up UTM tracking", "analyze marketing metrics", "launch a product", "optimize for SEO", "improve AI visibility", "optimize for voice search", "set up IndexNow", "check accessibility for SEO", or "create social media previews". Supports both marketing beginners and experienced marketers needing templates.
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Generate cold email templates, LinkedIn messages, follow-up sequences, and value propositions tailored to specific industries that actually get responses and book discovery calls.
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A/B Testing Plan Generator. Creates structured testing roadmaps with prioritized test sequences, duration calculators, sample size requirements, statistical significance thresholds, hypothesis templates, and 90-day testing calendars for Meta, Google, and LinkedIn.
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Create and optimize email marketing campaigns including sequences, newsletters, drip campaigns. Design subject line strategies, develop segmentation approaches, implement A/B testing, and establish analytics tracking for email performance.
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Instruments programs to record execution information for deterministic replay debugging. Use when debugging hard-to-reproduce bugs (race conditions, timing issues, intermittent failures, heisenbugs), reproducing production failures, or analyzing complex execution sequences. Records non-deterministic events (I/O, threading, randomness, time) to enable exact replay of program executions. Supports Python, JavaScript, Java, and C/C++ with both custom instrumentation and existing replay tools.
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Complete marketing pipeline for apps, dev tools, libraries, and SaaS products in 2026. Generates positioning, listing/ASO/package-SEO assets, press kit, launch plan, social calendar, email sequences, growth/referral strategy, paid playbook, retention, and community plan. Adapts automatically to app vs dev-tool vs SaaS. Trigger on: marketing, launch plan, app launch, go-to-market, ASO, press kit, product hunt launch, hacker news launch, dev tool marketing, growth strategy, launch checklist, marketing plan, distribution plan.
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Use when a user provides one baseline image and requests game animation frames, sprite sequences, attack/walk/idle/hit/death/casting motion, transparent PNG frames, a spritesheet, keyframe prompts, or consistent whole-character pose animation.
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Learn reusable 2D motion-generation knowledge from user-specified action resources with `/img2mo-learn <resource>`. Use when the user provides videos, extracted frame sequences, spritesheets, Spine assets, generated outputs, failed attempts, or reference motion folders and wants to summarize animation timing, pose beats, style traits, prompt patterns, extraction/cropping rules, or failure lessons into the project `img2mo-knowledge/` folder for later `/img2motion` generation.
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