150 skills · sorted by relevance
Prices FX options and exotic structures with Garman-Kohlhagen, local volatility, and stochastic volatility models. Use when pricing FX derivatives, evaluating FX options, or modeling cross-currency products.
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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.
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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the gene-independent DNA-damage / G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.
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Windows アプリ開発 (Windows App SDK / WinRT) の OS 統合 API リファレンス。 DeviceInformation, DeviceWatcher, センサー (Accelerometer, Gyrometer, Pedometer, Compass, OrientationSensor, ActivitySensor), Bluetooth LE, USB, Serial, HID, Battery, HttpClient, StreamSocket, WebSocket, BackgroundDownloader/Uploader, NetworkInformation, PointerInput, KeyboardInput, IME/TextInput, FocusManager, DragAndDrop, ResourceLoader (多言語化・地域化), Calendar, DateTimeFormatter, CurrencyFormatter, PasswordVault, OAuth2Manager, Web Account Manager (WAM) / MSAL, WebAuthenticationBroker, WindowsHello/Passkeys, Age signals, CryptographicBuffer, Clipboard, DataTransferManager, Launcher, ProtocolActivation, JumpList, TaskbarManager, SecondaryTile, StartupTask, Smart App Control, Phone Link。
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The shared Codex web-work inbox. Use when a coding agent needs browser work, provider account setup, OAuth or ecommerce portal work, npm publishing, or recovery of an incomplete Vault/account handoff delegated to Codex.
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Method for choosing and auditing an agent's reasoning_effort. Use when setting or reviewing reasoning_effort, when an agent was created with high, or when asked to cut reasoning spend. NOT for changing an agent's model (use test-model-selection).
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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.
The English summary is being prepared. Showing the original description.
Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.
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Provider account and authenticator setup through Matrx Vault. Use when creating a service account, saving its login, enrolling 2FA, or verifying agent sign-in with Vault credentials.
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The CI cost rules ($100/week of real money, all CI). Use when editing .github/workflows, adding a schedule or cron, dispatching a workflow, publishing a package version, hitting a billing block, or seeing a CI SPEND OFF TRACK line, ci-breaker issue or spend alert.
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The runbook a triage agent follows on each run over the super-admin attention dock, through the attention MCP tool. Use when a scheduled attention-triage routine wakes, when asked to triage, clean up or shrink the attention dock or admin alerts, or when the dock's card is over budget.
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Picks the model a coding agent uses when a test or browser check sends an AI call. Use when choosing a model for any test, UI check, bench, or agent run, or when a test names Opus, Sonnet, Fable, Astra, or any model by habit.
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The complete rules for writing or editing a shape's component (kind component). Use when creating, editing, patching or fixing a kind component, calling any kindcomp_* tool, or when a shape renders empty, broken, cropped, cramped or ugly.
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Rules for the shared MatrxDataTable and its drill-down. Use when configuring, migrating or reviewing table columns, filters, toolbars, record links or pagination, adding group-by, 'by X' analytics or counts and sums by status, owner, model or day, or replacing hand-built totals or lists.
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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.
The English summary is being prepared. Showing the original description.
Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.
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Lean, sharp UI posture — the everyday default for building or redesigning a UI. Use when asked to build or make a page, panel, list, form, or dashboard good, cleaner, or nicer, or for a fast confident refresh where the agent uses its judgment instead of asking for a spec.
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THE full UI surface checklist (S1–S18) run on one assigned surface. Use for a named surface check, `/surface-check <surface>`, or a claimed `surface-certification` Work Loop item. NOT for fleet selection or claims (use surface-certification-loop).
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Moves a person's whole Notion workspace into AI Matrx using only the AI Matrx and Notion connectors — every page and sub-page becomes an AI Matrx page (a Space) with its blocks, icons, covers, files and comments, and every database becomes a real table with typed columns, links, roll-ups, row pages, templates and views. Safe to run again; nothing duplicates. Use when the person says "move my Notion into AI Matrx", "copy my Notion", "import my Notion", or anything like it.
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Extract exactly what the person typed in a Claude Code session (script, no agent context spent), have a fresh agent write a faithful structured summary under it, and optionally have an adversarial agent judge whether the working agent is still on track. Use at a checkpoint, before a handoff, after a compaction, when a long session may have drifted from what the owner asked, or when told to 'summarize what I said' or 'check we're on track'.
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Trial protocol for teaching AI Matrx an expert's knowledge until the platform breaks, fixing it. Use when asked to run an expertise trial, distil a person/creator/recent video into a Masterwork, or test the capture product. NOT for a known-missing feature (use build-sub-feature).
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WindowPanel (@ai-matrx/summon/window) and its window manager. Use when a window won't drag, resize, minimize or pop out, the tray or restore is wrong, rendering <WindowPanel> on a page, or editing features/window-panels/**. NOT for opening or registering overlays (use overlay-system).
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Brokered short-lived provider credentials client in matrx-frontend (`lib/api/broker/`). Use when browser code needs a provider realtime session, a direct provider call, an ephemeral token, or a provider API key in the browser or `NEXT_PUBLIC_*`. NOT for adding a new audience server-side (use aidream's token-broker).
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Splits one big Claude task or automation into a set of focused AI Matrx agents that work on the person's own AI Matrx tables, then builds and test-runs each one. Use when the person says "split my task into agents", "turn my automation into AI Matrx agents", "make agents for my work", or after their data has moved into AI Matrx.
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