100 skills · sorted by relevance
Use when developing desktop applications with Qt in C++ - CMake setup, signals and slots, QThread and QtConcurrent, QML integration, model/view programming, Qt5 to Qt6 migration, or windeployqt/macdeployqt/linuxdeployqt deployment
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Stores and operates on sparse expression matrices for single-cell and large bulk RNA-seq, covering dgCMatrix/dgRMatrix/dgTMatrix when-each-is-fast, the dgCMatrix (CSC, R) <-> CSR (Python) implicit transpose, AnnData (cells-rows) <-> SingleCellExperiment (cells-cols) orientation flip, HDF5/h5ad vs Zarr cloud-native shift, HDF5SummarizedExperiment + DelayedArray for out-of-memory bulk, scanpy backed mode for large h5ad, the ~10-15% density crossover where dense beats sparse, 10X format proliferation (MTX vs CellRanger H5 vs h5ad), the dense-conversion memory blow-up, and Dask + Zarr for consortium-scale matrices. Use when choosing sparse format, working with single-cell-sized matrices, importing/exporting 10X, debugging R/Python interop transposes, processing matrices too large for RAM, or building cloud-native pipelines.
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Modern C++ project setup: CMake/CMakePresets, vcpkg, Ninja, VS Code/clangd, GoogleTest, clang-format/tidy, Doxygen, CI, macOS/Linux/Windows. Use for bootstrapping or modernizing host-side C++ apps and libraries; prefer embedded-project-setup for MCU firmware and cross-debug flows.
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Embedded firmware setup: STM32, ESP32, AVR, RP2040, Nordic nRF, Zephyr/RTOS, vendor SDKs, CMake/CMakePresets, VS Code/clangd, cross toolchains, flash/debug, Docker/CI. Use for MCU scaffolds, existing firmware modernization, BSPs, linker/startup files, SDK package selection, and embedded CI; prefer cpp-project-setup for host-side C++.
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Stores and operates on sparse expression matrices for single-cell and large bulk RNA-seq, covering dgCMatrix/dgRMatrix/dgTMatrix when-each-is-fast, the dgCMatrix (CSC, R) <-> CSR (Python) implicit transpose, AnnData (cells-rows) <-> SingleCellExperiment (cells-cols) orientation flip, HDF5/h5ad vs Zarr cloud-native shift, HDF5SummarizedExperiment + DelayedArray for out-of-memory bulk, scanpy backed mode for large h5ad, the ~10-15% density crossover where dense beats sparse, 10X format proliferation (MTX vs CellRanger H5 vs h5ad), the dense-conversion memory blow-up, and Dask + Zarr for consortium-scale matrices. Use when choosing sparse format, working with single-cell-sized matrices, importing/exporting 10X, debugging R/Python interop transposes, processing matrices too large for RAM, or building cloud-native pipelines.
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Stores and operates on sparse expression matrices for single-cell and large bulk RNA-seq, covering dgCMatrix/dgRMatrix/dgTMatrix when-each-is-fast, the dgCMatrix (CSC, R) <-> CSR (Python) implicit transpose, AnnData (cells-rows) <-> SingleCellExperiment (cells-cols) orientation flip, HDF5/h5ad vs Zarr cloud-native shift, HDF5SummarizedExperiment + DelayedArray for out-of-memory bulk, scanpy backed mode for large h5ad, the ~10-15% density crossover where dense beats sparse, 10X format proliferation (MTX vs CellRanger H5 vs h5ad), the dense-conversion memory blow-up, and Dask + Zarr for consortium-scale matrices. Use when choosing sparse format, working with single-cell-sized matrices, importing/exporting 10X, debugging R/Python interop transposes, processing matrices too large for RAM, or building cloud-native pipelines.
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Analyze drug concentration and response data to calculate exposure, fit models of drug movement and effects, and simulate dosing schedules. Produces exploratory research results with explicit assumptions and diagnostic checks.
Build text tokenizers that split multilingual text into small units for AI models. Learn how to train SentencePiece on raw text, configure BPE or Unigram splitting methods, and convert text to token IDs and back.
Build Zoom meeting integrations in Windows C++ applications, including custom interfaces and bots that run without a visible interface. Guidance covers authentication, audio and video data access, project setup, and troubleshooting callbacks through the Windows message loop.
Close out a launched Claude Managed Agent by listing its recorded components and completed phases. Refresh a shareable, self-contained HTML overview and rank the next one or two upgrades from deferred work and operational improvements.
Turn a validated build sheet into four API request files and a resumable launch script for Claude Managed Agent. Check the files for exposed keys before users launch with their own Anthropic key.
Add new operators to MNN through a staged workflow covering data definitions, output shapes, computation, and tests. It prioritizes combining existing operators, with CPU implementations and additional hardware backends used when needed.
Build text tokenizers, which split text into units for AI models, directly from raw multilingual text. Learn custom vocabularies with BPE or Unigram, convert text to pieces or numeric IDs, and decode the results.
Write or modernize C++ with guidance on C++20, C++23, and C++26 features. Review memory ownership, error handling, and template constraints, with recommendations for compiler protections and runtime checks that detect bugs.
Migrate legacy .NET project files to SDK-style format, reducing repetitive XML and explicit file lists. Convert package references, move assembly metadata into project settings, and consolidate shared build and package settings across multiple projects.
Capture MSBuild execution records as binary logs during .NET builds, tests, packaging, publishing, or restores. It explains unique filenames, PowerShell quoting, and file checks so logs remain available for later failure or performance analysis.
Build Holoscan SDK from source via the in-tree ./run script. Use only when published packages don't meet the user's needs.
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Use this skill for MolMIM, NVIDIA's BioNeMo NIM microservice for small-molecule latent-space generation and optimization. Invoke for MolMIM, molecular embeddings, hidden states, latent decoding, sampling around a seed SMILES, CMA-ES guided molecule generation, QED or plogP optimization, hosted NVIDIA API calls, or local Docker deployment.
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Retro arcade-inspired design with pixel fonts, dotted borders, playful high-contrast colors, and 8-bit game aesthetics.
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Diagnoses and resolves Amazon RDS for Oracle connectivity, authentication, networking, and driver troubleshooting. Applicable to any RDS-for-Oracle question including connecting a Python Lambda to RDS Oracle in a VPC with pooling and cold-start optimization, EKS pods to RDS Oracle via the Secrets Manager CSI driver with IRSA and SecretProviderClass, ORA-12170 cross-VPC timeouts from EC2, DPI-1047 cannot-locate-64-bit-Oracle-Client errors, and Oracle Connection Manager (CMAN) on EC2 as a proxy with HA across two AZs. Covers python-oracledb thin vs thick mode, init_oracle_client, RDS Proxy does NOT support RDS Oracle, port 1521, VPC peering, Transit Gateway, Kerberos with AWS Managed Microsoft AD, SSL/TLS/NNE, SSM port forwarding, EC2/ECS Fargate/EKS/Lambda, SQL Developer/DBeaver/Toad/SQLcl, and Secrets Manager.
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Prepare and run XQUIC local compilation. Use when asked to compile, build, configure, or diagnose the local build environment for XQUIC, especially across macOS/Linux. Detect intent and platform, then delegate actual compilation to scripts/validate.sh instead of hand-writing CMake commands.
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Light and shade a three.js scene: choose materials (MeshStandardMaterial PBR vs unlit MeshBasicMaterial), add ambient/hemisphere/directional/point/spot lights, turn on shadow maps, and use an environment map (IBL) for realistic reflections. Use when a three.js model looks black, flat, or wrong — when the user mentions three.js materials, MeshStandardMaterial, lights, shadows, envMap, or PBR. For renderer/loop setup use threejs-scene-setup; for loading models use threejs-gltf-loading.
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Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.
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Expertise complète en droit français des étrangers, de l'asile et de la nationalité — entrée et visas, séjour (CESEDA livre IV, AES, étranger malade, regroupement familial, métiers en tension), éloignement et contentieux (OQTF, IRTF, rétention, référés, TA/CAA/CE), asile (OFPRA, CNDA, Dublin, CMA/ADA), nationalité et droits sociaux des étrangers (AME, PUMa, RSA, AAH, ASPA). Interroge en priorité trois connecteurs MCP complémentaires — OpenLegi (textes, jurisprudence administrative), LibreJustice (recherche sémantique tous ordres) et Legal Data Hunter (rétention/JLD, graphe de citations, statut de validité) — puis les sources officielles (Légifrance, ANEF, OFPRA, CNDA) et la doctrine associative (GISTI, Cimade, ADDE, Comede, Anafé). Déclencher dès qu'une question porte sur un étranger en France, même sans vocabulaire juridique — « papier de la préfecture », « récépissé périmé », « la CAF refuse le RSA » — et pour toute consultation, recours, note ou vérification de références dans ces matières.
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