582 skills · sorted by relevance
Calculate read depth and coverage across genomic intervals using bedtools genomecov and coverage. Generate bedGraph files, compute per-base depth, and summarize coverage statistics. Use when assessing sequencing depth, creating coverage tracks, or evaluating target capture efficiency.
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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
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将本地视频转换为近亮远暗的连续灰度深度视频，使用 Video Depth Anything 时序模型，保留时长和可选原声。用于深度控制视频、depth video、视频深度估计。
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Add or refine depth through elevation systems, raised and inset surfaces, layered overlap, and meaningful shadow behavior so interfaces feel structured instead of flat. Use when the user mentions depth, elevation, shadows, layering, flat cards, pressed states, drag feedback, or inset controls.
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Generate Rocaille-style domain warping shaders, mouse-reactive liquid logo effects, depth-map parallax heroes (Astryx-style hover-reactive statues), and stable fluid simulations over live DOM. Four modes — rocaille, liquid-logo, astryx-statue, fluid-dom. Triggers on shader art, depth parallax, hover-reactive depth map, statue hero, fluid sim, liquid logo, WebGL visualization, procedural background, pointer-reactive fluid.
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Generate 3D models from text or images via 5 providers: Meshy (text-to-3D, texturing, batch), fal.ai Hunyuan3D Pro ($0.225, PBR), WaveSpeedAI Rapid ($0.0225, bulk), Trellis 2 (poly control), and Local Depth (free offline ONNX depth maps + mesh). Includes GLB viewer. Triggers on 3D model, image to 3D, GLB, depth map, text to 3D, texturing, 3D asset, Meshy, Hunyuan.
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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
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サービス開発のためのデプスインタビューを実施し、ユーザーの真のニーズ・課題・動機を引き出す。5 Whys、ラダリング法を用いてプロダクト開発に活かせるインサイトを発見する。ユーザーリサーチ、課題発見、ペルソナ構築、プロダクト仮説検証に使用する。Do NOT use for キャリア相談やキャリアカウンセリング（depth-interviewing-careerを使用すること）。
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キャリア設計のためのデプスインタビューを実施し、本人の価値観・強み・動機を引き出す。5 Whys、ラダリング法を用いてキャリアビジョンの明確化を支援する。転職相談、自己理解、キャリアカウンセリング、1on1面談の深掘りに使用する。Do NOT use for 製品・サービスのユーザーリサーチ（depth-interviewing-productを使用すること）。
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Applies depth-driven layered color and shadow principles to elevate average UI into polished, readable interfaces for both light and dark themes. Use when improving or reviewing UI components, setting up a design token system, applying consistent depth and shadow to an interface, or making a flat or inconsistent UI feel more refined without a full redesign.
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Execute and test GraphQL depth limit attacks using deeply nested recursive queries to identify denial-of-service vulnerabilities in GraphQL APIs.
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Add or refine depth through elevation systems, raised and inset surfaces, layered overlap, and meaningful shadow behavior so interfaces feel structured instead of flat. Use when the user mentions depth, elevation, shadows, layering, flat cards, pressed states, drag feedback, or inset controls.
The English summary is being prepared. Showing the original description.
Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
The English summary is being prepared. Showing the original description.
Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
The English summary is being prepared. Showing the original description.
Choose how detailed an answer should be before it is written, using four levels and estimated token counts, a measure of text length. The skill then adjusts the response and keeps the chosen level for subsequent replies.
Research a topic across multiple web sources, break it into focused questions, and read key pages in depth. Produce a report with source links, confidence levels, practical findings, and clear distinctions between facts and estimates.
Investigate complex topics using web sources, stored knowledge, and relevant code. Break questions into smaller parts, compare evidence, and produce a structured report with confidence assessments, unresolved questions, and next steps.
Document a project's structure, commands, and specific conventions in a hierarchy of AGENTS.md files. Analyze directory complexity to choose useful locations, update existing guidance, and check that child files avoid repeating their parents.
Add zooms, pans, masks, moving text, and depth to HyperFrames compositions. Build animation states that remain correct when jumping to any point in time, then inspect motion and final frames with diagnostics and snapshots.
Design scene transitions and animated text using matched movement direction and speed across cuts. The catalog provides concrete settings for zooms, blur, word-by-word transitions, staggered entrances, and repositioning groups of elements.
Delegate a feature, bug fix, or substantial code change and carry it through implementation, review, and verification. Start from a task description or issue link, with options for the workflow route and review depth.
Work with genomic regions in Polars tables to find overlaps, nearby regions, covered bases, and gaps. Read and write bioinformatics files, query data with SQL, and check coordinate conventions when joining datasets or migrating from bioframe.
Build web interfaces with floating cards, spatial depth, and translucent glass effects using GSAP and 3D CSS. Add scroll animations while preserving keyboard navigation and providing static states for users who request reduced motion.
Turn code files into learning resources by adding comments that explain syntax, programming concepts, and design choices. Adjust explanation depth and repetition to the reader’s knowledge while preserving file structure, encoding, and syntax.