Results for “pert”

Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

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Automatically infer formal correctness properties from Verilog/SystemVerilog RTL code and generate SystemVerilog Assertions (SVA). Identifies control-flow invariants (mutual exclusion, valid-ready handshakes, pipeline ordering, safety properties), liveness expectations, and temporal properties. Use when working with RTL designs that need formal property generation, when adding assertions to existing RTL, or when users ask to infer properties, generate assertions, or create formal specifications from hardware designs.

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Generate test cases using metamorphic testing by applying transformations based on metamorphic properties. Use when you need to expand test suites, test programs without oracles, validate mathematical or algorithmic properties, or detect subtle bugs through input-output relationships. The skill takes a program, original test cases, and metamorphic properties as input, generates new test cases by applying transformations, executes tests, verifies outputs satisfy properties, reports violations and anomalies, and outputs an expanded test suite with property coverage summary. Supports multiple programming languages and property types.

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CesiumJS time, properties, and animation - Clock, JulianDate, TimeInterval, Property, SampledProperty, CallbackProperty, PathMode, interval and sampled path materials, interpolation, splines, CZML temporal data. Use when making entity attributes or path materials time-dynamic, configuring the simulation clock, interpolating positions, or working with sampled, interval, or callback properties.

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Android Jetpack Compose Expert workflow skill. Use this skill when the user needs Expert guidance for building modern Android UIs with Jetpack Compose, covering state management, navigation, performance, and Material Design 3 and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

The English summary is being prepared. Showing the original description.

Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

The English summary is being prepared. Showing the original description.

Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

The English summary is being prepared. Showing the original description.

Build and review ViewModels, objects that manage screen state and actions, with CommunityToolkit.Mvvm. Use attributes to generate change notifications and commands, add input validation, and handle asynchronous operations, cancellation, and command availability.

• Add properties that notify the screen when values change
• Create asynchronous commands with cancellation
• Validate registration forms and settings

Test whether API users can read or change fields beyond their permissions. Examine responses for sensitive data, inject extra request fields to check unauthorized updates, and use explicit lists of allowed fields to guide fixes.

• Check API responses for excessive sensitive data
• Test whether added request fields allow unauthorized updates
• Compare field access across user privilege levels

Use this skill to analyze an existing PostgreSQL database and identify which tables should be converted to Timescale/TimescaleDB hypertables. **Trigger when user asks to:** - Analyze database tables for hypertable conversion potential - Identify time-series or event tables in an existing schema - Evaluate if a table would benefit from Timescale/TimescaleDB - Audit PostgreSQL tables for migration to Timescale/TimescaleDB/TigerData - Score or rank tables for hypertable candidacy **Keywords:** hypertable candidate, table analysis, migration assessment, Timescale, TimescaleDB, time-series detection, insert-heavy tables, event logs, audit tables Provides SQL queries to analyze table statistics, index patterns, and query patterns. Includes scoring criteria (8+ points = good candidate) and pattern recognition for IoT, events, transactions, and sequential data.

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Generate real estate, architecture, and interior design showcase video prompts for Seedance 2.0 on Higgsfield. Use whenever the user wants property tours, real estate listings, architecture showcases, interior design videos, home staging content, property marketing, virtual tours, construction reveals, or any real estate/architecture video. Triggers on: real estate, property, house, apartment, architecture, interior design, home tour, listing video, property marketing, virtual tour, building, construction, renovation, home staging, or any real estate/architecture video request. Use even for "make a video for my listing" or "showcase this property.

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Automatically repair code violations of temporal properties using model-checking counterexamples as guidance. Use when working with formal verification results, temporal logic property violations (LTL, CTL), model checking counterexamples, or when asked to repair property violations, fix counterexamples, repair temporal properties, fix model checking violations, or repair code based on counterexamples. Applicable to concurrent systems, state machines, synchronization issues, safety/liveness properties, and resource management violations.

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Android Jetpack Compose Expert workflow skill. Use this skill when the user needs Expert guidance for building modern Android UIs with Jetpack Compose, covering state management, navigation, performance, and Material Design 3 and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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Extract a founder's or expert's point of view — core beliefs, contrarian takes, origin stories, taste — and synthesize a recommended "one big idea" (OBI) that anchors thought leadership and brand voice. Writes to marketing/expert-pov/expert-pov.md. Triggers - "expert pov", "founder point of view", "thought leadership angle", "one big idea", "OBI", "founder beliefs", "founder narrative"

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Modern PHP idioms for any PHP project (PHP 8.1+): readonly properties, enums, match expressions, constructor property promotion, typed properties, named arguments, nullsafe operator, first-class callable syntax, strict_types, PSR-12 style, and null discipline. Apply when the project is a PHP 8.1+ project. Stack-agnostic — referenced by every PHP plugin in the marketplace. Use this skill to: - Write strongly-typed, immutable-by-default value objects with readonly properties and enums. - Replace switch ladders and magic constants with match expressions and backed enums. - Cut constructor boilerplate with property promotion and express optionality with typed nullable returns. - Keep code PSR-12 compliant with declare(strict_types=1) in every file. Do NOT use this skill for: - Framework-specific idioms (Eloquent, Doctrine, Symfony services, Laravel facades — those live in framework plugin skills). - Composer / autoloading / dependency management — see php-foundation:composer-tooling. - Testing patterns — see php-foundation:php-testing.

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Builds comprehensive design systems and design bibles with production-ready CSS. Expert in design tokens, component libraries, CSS architecture. Use for design system creation, token architecture, component documentation, style guide generation. Activate on "design system", "design tokens", "CSS architecture", "component library", "style guide", "design bible". NOT for typography deep-dives (use typography-expert), color theory mathematics (use color-theory-palette-harmony-expert), brand identity strategy (use web-design-expert), or actual UI implementation (use web-design-expert or native-app-designer).

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Determines whether to screen a patient with hypertension for primary aldosteronism based solely on the presence of hypertension. Use when a clinician asks whether to screen a hypertensive patient for PA, triggered by phrases such as "should we screen for aldosteronism" or "evaluate for secondary hypertension".

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Builds comprehensive design systems and design bibles with production-ready CSS. Expert in design tokens, component libraries, CSS architecture. Use for design system creation, token architecture, component documentation, style guide generation. Activate on "design system", "design tokens", "CSS architecture", "component library", "style guide", "design bible". NOT for typography deep-dives (use typography-expert), color theory mathematics (use color-theory-palette-harmony-expert), brand identity strategy (use web-design-expert), or actual UI implementation (use web-design-expert or native-app-designer).

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Train and run Uni-Mol Tools models to predict molecular properties from CSV data. Organize experiments into projects, compare model performance, rank results, and manage storage through interactive commands or machine-readable JSON output.

• Train molecular property models from CSV data
• Predict properties with a trained model
• Organize experiments and compare model performance

Prepare for investment diligence meetings with management, experts, customers, or advisors. Create a one-page brief with prioritized questions, comparison metrics, concerns to investigate, and follow-up requests based on the meeting's purpose and existing findings.

• Prepare questions for a management presentation
• Plan an industry expert call
• Check customer satisfaction and renewal intentions

Helps configure and troubleshoot DeepSpeed for training large models across multiple devices. Covers memory optimization, parallel training, and DeepNVMe storage transfers, with examples for tuning data movement and configuring models that divide work among specialized components.

• Configuring distributed training for large models
• Tuning tensor transfers to NVMe storage
• Setting up models with specialized expert components

Develop time-series and event-data solutions with TimescaleDB, an extension for PostgreSQL. The skill provides organized references for installation, time-based tables, ongoing aggregate calculations, compression, and performance troubleshooting.

• Learn how to install and use TimescaleDB
• Design tables for time-series and event data
• Implement time-bucket and continuous aggregates

Maintain Tika's registry of metadata keys, the names used for document attributes. Guides regeneration after key changes, checks generated files against code, applies naming rules, and finds outdated references after renaming.

• Adding a Tika metadata key
• Renaming keys and finding outdated references
• Investigating metadata schema test failures