2.6K skills · sorted by relevance
Prepare and launch nf-core/pacsomatic workflows for matched tumor and normal PacBio HiFi samples. Generate sample sheets and launch files from unaligned BAM inputs, run local checks, submit cluster launchers, and troubleshoot startup failures.
Assess Microsoft Entra ID with AADInternals during authorized security testing. Examine publicly exposed tenant information, API access, and federation weaknesses, including Golden SAML, a token forgery technique, then document evidence and recommendations for stronger identity protection.
Run end-to-end calibration on the shipped sample dataset (sdg_08_2_sample_data_010926.zip) against a running AMC microservice. Use when user says 'test sample dataset', 'run sample calibration', 'verify AMC install', or 'launch and test'.
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Structured logging extensions for Golang using samber/slog-**** packages — multi-handler pipelines (slog-multi), log sampling (slog-sampling), attribute formatting (slog-formatter), HTTP middleware (slog-fiber, slog-gin, slog-chi, slog-echo), and backend routing (slog-datadog, slog-sentry, slog-loki, slog-syslog, slog-logstash, slog-graylog...). Apply when using or adopting slog, or when the codebase already imports any github.com/samber/slog-* package.
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In-memory caching in Golang using samber/hot — eviction algorithms (LRU, LFU, TinyLFU, W-TinyLFU, S3FIFO, ARC, TwoQueue, SIEVE, FIFO), TTL, cache loaders, sharding, stale-while-revalidate, missing key caching, and Prometheus metrics. Apply when using or adopting samber/hot, when the codebase imports github.com/samber/hot, or when the project repeatedly loads the same medium-to-low cardinality resources at high frequency and needs to reduce latency or backend pressure.
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Dependency injection in Golang using samber/do — service containers, lifecycle management, scopes, health checks, graceful shutdown, and module organization. Apply when using or adopting samber/do, when the codebase imports github.com/samber/do or github.com/samber/do/v2, or when refactoring manual constructor injection into a DI container.
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Golang refactoring — safe, at-scale restructuring of existing Go code: a coverage-adaptive safety net, behavior-preserving transforms (gopls Rename/Extract, `gofmt -r`, `gopatch`), the Fowler catalog mapped to Go, breaking import cycles, and small stacked PRs. Apply when a function or type has grown too large, a code smell blocks a feature, or the user asks to refactor Go code — also for renaming at scale, extracting functions or interfaces, moving code between packages, or planning a multi-step refactor. Target styles owned elsewhere → See `samber/cc-skills-golang@golang-naming` (renames), `samber/cc-skills-golang@golang-project-layout` (splits), `samber/cc-skills-golang@golang-modernize` (idioms), `samber/cc-skills-golang@golang-code-style` (control flow), `samber/cc-skills-golang@golang-design-patterns` (patterns/DI).
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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.
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AWS SAM and AWS CDK deployment for serverless applications. Triggers on phrases like: use SAM, SAM template, SAM init, SAM deploy, CDK serverless, CDK Lambda construct, NodejsFunction, PythonFunction, SAM and CDK together, serverless CI/CD pipeline. For general app deployment with service selection, use deploy-on-aws plugin instead.
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Use when reviewing a Rezolus sampler change before merge — a new sampler, a change to an existing sampler's probes/refresh/metrics, or core changes that affect samplers; or whenever a sampler's overhead, cadence, or data source is in question.
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Establishes a disciplined malware sample repository: content-addressed storage by hash, encrypted/password-protected archiving, consistent metadata records, and chain-of-custody tracking so samples are reproducible and safe to handle. Activates for requests to organize a malware repository, manage samples, or track sample metadata and provenance.
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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.
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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.
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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.
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Analyze a set of design samples (HTML mockups + website URLs) and produce a structured style guide that anchors the rest of the stardust redesign pipeline. Use when the user supplies reference designs ("design samples", "mockups", "inspiration sites", "style references") and wants to extract a consistent visual language — type system, color palette, spacing, motion, and reusable component patterns — before redesigning a target site. Triggers on phrases like "distill these samples", "extract a style guide from these examples", "use these as design references", or "analyze these mockups". Outputs a `trait-matrix.json` (structured per-sample + cross-sample design tokens) and a `SAMPLES.md` narrative brief that `stardust:direct` reads under Mode B (anchor-reference precedence) when picking a redesign direction.
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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.
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Locate CCSGameRules::SameMapTeardown in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the local gamedata entry "CCSGameRules::SameMapTeardown" (symbol CCSGameRules_SameMapTeardown). This is a non-virtual function - emit a byte signature (func_sig), not an offset. Locate it via cross-references, distinctive constants/strings in its body, or callers of related symbols; verify by decompilation before committing to a candidate. Trigger: CCSGameRules_SameMapTeardown, CCSGameRules::SameMapTeardown
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Build, run, and troubleshoot data processing pipelines with Nextflow and nf-core. The skill guides modular workflow development, input preparation, testing, cached restarts, and configuration for local computers, computing clusters, or cloud environments.
Plan experiments before collecting data. Helps choose study designs, randomly assign subjects or samples, organize treatment combinations, and generate reproducible schedules while checking for confounding and repeated measurements incorrectly counted as independent samples.
Build AWS applications that run without managing servers directly. Covers Lambda functions, APIs, DynamoDB storage, message-driven workflows with SQS/SNS, deployment through SAM/CDK, and reducing the delay when a function starts for the first time.
Estimate a venture’s market size using industry reports, customer counts and pricing, or willingness to pay. Organize results into total, serviceable, and realistically obtainable revenue opportunities to support business planning and investor presentations.
Turn code from the current session into a focused blog walkthrough with a generalized code sample and usage example. Learn the author's style from writing samples, adapt to the destination, and save only after approval.
Examine Windows and Active Directory logs for attempts to extract passwords and other credentials. Identify suspicious memory access and database exports, correlate events with user and host context, and produce findings with severity ratings and detection queries.
Validate Illumina BCL run folders and sample sheets, plan demultiplexing—the separation of reads by sample—and convert data to FASTQ using installed tools. Review conversion metrics, index settings, and reads that could not be assigned.