207 skills · sorted by relevance
Implementing distributed tracing with W3C Trace Context — the byte-precise `traceparent` and `tracestate` header formats, OpenTelemetry's W3CTraceContextPropagator as the modern default (replacing X-B3-* and X-Datadog-*), head vs tail sampling, and HTTP→SQL trace propagation via sqlcommenter. Grounded in the W3C REC and OpenTelemetry specs.
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Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.
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Determines unilateral vs bilateral aldosterone excess based on cortisol-corrected aldosterone ratios from adrenal venous sampling, with ratio >4:1 indicating unilateral excess, ratio 3:1 suggestive of bilateral hypersecretion, and interpretation dependent on cosyntropin stimulation protocol used during sampling. Use when analyzing AVS results to guide surgical vs medical treatment decisions; triggers include 'AVS lateralization ratio', 'cosyntropin-stimulated AVS', 'aldosterone-to-cortisol ratio >4:1', and 'ratio 3:1 suggestive of bilateral disease'.
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Expert-level signal processing covering Fourier analysis, sampling theory, digital filters, FFT, spectral estimation, and adaptive filtering.
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Patterns for loading PDE simulation datasets (PDEBench, PhiFlow, JAX-CFD) from HDF5 files. Handles layout detection (single tensor vs separate variables), spatial/temporal downsampling, multi-variable systems, HuggingFace and DaRUS data sources, and efficient PyTorch DataLoader creation. Use when preparing PDE data for neural operator training.
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Estimates time-scaled phylogenies, molecular clock rates, effective reproduction number R_e (or R_t), and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict / uncorrelated lognormal / ORC clocks; constant / exponential / Bayesian Skyline / Skygrid / BICEPS / Birth-Death-Skyline / sampled-ancestor BDSKY priors; structured coalescent via MASCOT). Covers root-to-tip clock signal QC via TempEst, date-randomisation tests (Ramsden 2009; Duchêne 2015), recombination masking via Gubbins and ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction (Volz & Frost 2014; preferential-sampling extensions), MASCOT structured coalescent for migration, BICEPS-vs-BSP skyline choice, multi-chain BEAST2 convergence diagnostics, and reconciliation between phylodynamic R_e and case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline (Stadler 2013) models, diagnosing temporal-signal failure, masking recombination before clock inference for *Streptococcus pneumoniae* / *Neisseria gonorrhoeae* / *Klebsiella* / *E. coli* phylodynamics, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.
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Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.
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Estimates time-scaled phylogenies, molecular clock rates, effective reproduction number R_e (or R_t), and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict / uncorrelated lognormal / ORC clocks; constant / exponential / Bayesian Skyline / Skygrid / BICEPS / Birth-Death-Skyline / sampled-ancestor BDSKY priors; structured coalescent via MASCOT). Covers root-to-tip clock signal QC via TempEst, date-randomisation tests (Ramsden 2009; Duchêne 2015), recombination masking via Gubbins and ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction (Volz & Frost 2014; preferential-sampling extensions), MASCOT structured coalescent for migration, BICEPS-vs-BSP skyline choice, multi-chain BEAST2 convergence diagnostics, and reconciliation between phylodynamic R_e and case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline (Stadler 2013) models, diagnosing temporal-signal failure, masking recombination before clock inference for *Streptococcus pneumoniae* / *Neisseria gonorrhoeae* / *Klebsiella* / *E. coli* phylodynamics, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.
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Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.
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Implementing distributed tracing with W3C Trace Context — the byte-precise `traceparent` and `tracestate` header formats, OpenTelemetry's W3CTraceContextPropagator as the modern default (replacing X-B3-* and X-Datadog-*), head vs tail sampling, and HTTP→SQL trace propagation via sqlcommenter. Grounded in the W3C REC and OpenTelemetry specs. NOT for OTel metrics/logs pipelines, vendor backend setup (Datadog/Honeycomb/Jaeger/Tempo), or browser RUM tracing.
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Support manufacturing quality investigations from containment through root cause analysis and corrective action. Organize decisions about nonconforming materials, assess whether actions prevent recurrence, interpret process control charts, and address supplier quality problems.
Review local character animations before sharing previews or final renders. Check structured design data, asset files, browser errors, sampled motion frames, and MP4 metadata, then classify the result as pass, revise, or fail.
Build graph neural networks, models that learn from connected nodes, with PyTorch Geometric. Supports node and graph classification, link prediction, custom datasets, and training approaches for large graphs or graphs containing multiple types of nodes and connections.
Build quantum circuits with Qiskit, test them locally, and prepare them for IBM quantum hardware. The skill covers hardware-specific circuit conversion, sampling, expectation values, and analysis of measurement results, uncertainty, and resource usage.
Explore public pathogen genome data to verify lineage names, summarize weekly sequence proportions, examine reporting delays, and compare mutation frequencies. Results include filters and denominators, with clear limits on what submitted sequences reveal about infections.
Use COBRApy to model metabolic networks and calculate possible reaction flows under defined constraints. Compare gene knockouts, nutrient conditions, and production limits, while checking model validity and keeping computational predictions separate from experimental findings.
Turn graded execution traces and production logs into model training examples and preferred-versus-rejected response pairs. Select useful records, remove sensitive information, exclude evaluation examples, and preserve links to the original runs.
Set up distributed tracing with Jaeger and Tempo to follow requests across services. Examine delays, service dependencies, and error propagation, with guidance on sampling, linking logs to traces, and troubleshooting missing trace data.
Build and troubleshoot C#/.NET MCP servers that expose tools and information to AI agents. Guidance targets the official 2.x SDK and covers transport setup, authentication, interactive features, basic clients, and migration issues caused by changed defaults.
Apply statistical tests to financial time series, model changing volatility, and diagnose regression problems. Estimate uncertainty in strategy metrics through bootstrap resampling, which repeatedly samples existing data, and organize findings into a statistical testing report.
Build market research evidence by comparing two market-size estimates, calculating survey sample sizes for each customer group, and scoring potential segments. Outputs show methods and assumptions so teams can assess the basis for business decisions.
Inspect and remove invisible characters from text and AI provenance metadata, information about content origin, from images and documents. It also supports prose rewriting and reports what changed, with limits on verifying watermark removal.
Measure chat layout jumps while a response runs by tracking the Working line through CDP, a browser debugging connection. Count upward movements and compare the same prompt before and after changes to status lines, step rows, or folding behavior.
Record and query iii engine logs, traces that show how calls flow, and operational metrics. Set up reactions to incoming errors, inspect alerts, and review metrics aggregated over time windows.