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Validate Claude Ads data contracts, scoring inputs, run outputs, installation procedures, and release readiness. Return machine-readable pass or fail results with evidence, the most urgent blocker, and recovery steps, while checking source freshness and safe removal boundaries.
Validate, prepare, or run public CodonFM Encodon masked-codon variant scoring and review compatibility of its scoring workflows. Use only when the user explicitly requests CodonFM or Encodon, or that context is already established in the conversation. Do not select this skill for a generic variant-scoring request without that context; ask for the variant and intended analysis first.
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Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity scoring. Covers the motif-pruning-as-directionality principle, regulon specificity scoring, run-to-run stability, and database/species matching. Use when identifying TF regulons, scoring TF activity per cell, finding master regulators of cell identity, or comparing regulon activity across conditions. For enhancer-driven multiomic GRNs see multiomics-grn; for bulk inference and VIPER protein-activity see grn-inference.
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Provides R wrappers of several on-target and off-target scoring methods for CRISPR guide RNAs (gRNAs). The following nucleases are supported: SpCas9, AsCas12a, enAsCas12a, and RfxCas13d (CasRx). The available on-target cutting efficiency scoring methods are RuleSet1, Azimuth, DeepHF, DeepCpf1, enPAM+GB, and CRISPRscan. Both the CFD and MIT scoring methods are available for off-target specificity prediction. The package also provides a Lindel-derived score to predict the probability of a gRNA to
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JTBD opportunity scoring and prioritization - outcome statement format, opportunity algorithm, scoring interpretation, feature prioritization, and opportunity matrix template
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When a founder needs to qualify inbound leads, define their ICP, build a lead scoring model, set MQL criteria, or route prospects through pipeline stages. Activate when the user mentions lead scoring, ICP, MQL, SQL, lead qualification, inbound leads, or pipeline design.
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Vendor privacy risk tiering methodology for processor management. Covers scoring factors including data volume, sensitivity, transfer locations, certifications, breach history, and control maturity with weighted risk calculation and tier assignment.
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Guides comprehensive controller self-assessment covering GDPR Articles 5-49 with scoring methodology and reporting format. Activate when conducting internal reviews or benchmarking maturity. Keywords: self-assessment, controller assessment, compliance questionnaire, scoring.
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Provides combined DPIA and AI Act conformity assessment template with integrated risk scoring matrix. Covers GDPR Art. 35 DPIA elements, AI Act high-risk system requirements, mitigation measures, and human oversight assessment. Keywords: DPIA template, conformity assessment, risk scoring, AI Act, combined assessment, high-risk AI.
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ESM2 protein language model for sequence scoring, embeddings, and plausibility checks. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai1-structure-prediction or boltz-structure-prediction. For QC thresholds, use protein-design-qc.
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Use when scoring leads, qualifying prospects, prioritizing pipeline, deciding which accounts to pursue, or building a lead scoring model. Triggers: 'score this lead', 'qualify this prospect', 'is this a good lead', 'lead scoring', 'prioritize my pipeline', 'qualification framework'.
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Gate resumption of any multi-day LLM batch-scoring campaign that calls an unpinned model alias (deepseek-chat, gpt-*-latest, gemini-*-preview, any provider alias without a pinned version). Use when: (1) resuming a paused or credit-exhausted scoring run days after its last chunk, (2) topping up credits to finish a campaign, (3) extending a cached scoring pipeline with new items. Prevents silently splicing two model versions or serving revisions into one measure. Verified 2026-07-16: for $0.30 caught a serving-revision drift WITHIN DeepSeek v4-flash (same alias, same family, litigation scores systematically shifted across a 2-day gap) before an $83 resume spend.
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Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity scoring. Covers the motif-pruning-as-directionality principle, regulon specificity scoring, run-to-run stability, and database/species matching. Use when identifying TF regulons, scoring TF activity per cell, finding master regulators of cell identity, or comparing regulon activity across conditions. For enhancer-driven multiomic GRNs see multiomics-grn; for bulk inference and VIPER protein-activity see grn-inference.
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Hybrid ML + physics binding affinity prediction. Empirical scoring, MM/GBSA rescoring, multi-method consensus, and batch virtual screening for protein-ligand complexes.
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スコアリング / ML のドメイン正しさのレビュー。SCORE_WEIGHTS の単一定義と合計1.0・ドキュメント追随、スコアリングと ML の10要素の一致（手書きで並ぶ全箇所の同時更新）、未来情報リーク（as-of カットオフを通していない取得経路の新設）、値域0〜100とゼロ除算、データ欠損時の既定値、学習・予測の決定性と再現性、JRA 枠番割当規則、バックテスト指標（1位的中率・上位3頭精度・順位相関・ROI）の計算を検証。Use when user says 'スコアリングレビュー', 'review scoring', 'ML レビュー', 'スコア計算チェック', '特徴量チェック', or 'バックテスト検証'.
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Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity scoring. Covers the motif-pruning-as-directionality principle, regulon specificity scoring, run-to-run stability, and database/species matching. Use when identifying TF regulons, scoring TF activity per cell, finding master regulators of cell identity, or comparing regulon activity across conditions. For enhancer-driven multiomic GRNs see multiomics-grn; for bulk inference and VIPER protein-activity see grn-inference.
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Design structured evaluation rubrics for scoring LLM and agent outputs — defining quality dimensions, scoring scales, hard gates, score descriptions, and edge cases. Load when the user asks to create an eval rubric, define evaluation criteria, design scoring dimensions, write an eval spec, or says "what should I evaluate", "design a rubric", "create eval criteria", "define quality dimensions", "evaluation rubric for", "how do I measure quality of". Sub-skill of eval-output orchestrator.
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Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity scoring. Covers the motif-pruning-as-directionality principle, regulon specificity scoring, run-to-run stability, and database/species matching. Use when identifying TF regulons, scoring TF activity per cell, finding master regulators of cell identity, or comparing regulon activity across conditions. For enhancer-driven multiomic GRNs see multiomics-grn; for bulk inference and VIPER protein-activity see grn-inference.
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Assess a scoped competitor set across nine dimensions using evidence and consistent scoring criteria. Produce comparable profile cards and a two-axis positioning plot to show rival strengths, weaknesses, and competitors occupying the client's target space.
Design recommendation and ranking workflows that select the best items for a user or situation. Organize candidate retrieval, enrichment, filtering, scoring, selection, and background recording into six stages, then generate a runnable code scaffold.
Build clinical decision support for electronic medical records, covering drug interactions, dose validation, clinical risk scores, and alerts. Provides patterns for testable checking functions, severity-based interface behavior, and safety tests that detect missed warnings.
Build a scheduled agent that collects public website or API data, summarizes or scores it with Gemini Flash, and stores results. Includes guidance for duplicate removal and using user feedback to inform future scoring.
Compare competitors using evidence-backed scores for positioning, brand expression, services, credibility, and other dimensions. Produce consistent profile cards and a two-axis chart showing which rivals occupy the market position your client wants to claim.
Compare Claude, GPT, and Gemini on the same skill or prompt. Get a table of response times, token usage, and costs, with optional AI scoring to help choose a model for the task.