621 skills · sorted by relevance
Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.
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Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CA-CTCF/CA-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.
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This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
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Ticket/PRD intake: product-area classification, completeness scoring, RCA, technical assessment. Works with Jira, Linear, GitHub, or manual paste. Use to analyze or triage a ticket.
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Domain-aware complexity routing. Scans task description for domain keywords, matches against domain-complexity.csv, returns complexity level, workflow intensity, and execution tier. Extends Phase 0 orchestration.
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Detects task agent and complexity tier at Phase 0 orient. Invoked first in every workflow. Provider adapters select any model/runtime policy. NOT for runtime agent routing inside a single skill (see orchestration-rules.md).
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Parallel code verification using multiple models with severity classification
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P0 classification rules for community reports. Six categories that auto-headline regardless of reporter count. Reference doc — invoked by weekly-report when classifying.
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This skill provides criteria to distinguish unilateral from bilateral primary aldosteronism using adrenal venous sampling results, including lateralization index, contralateral ratio, and clinical factors. It is triggered after AVS when clinicians analyze results and ask 'Is this unilateral or bilateral PA?' or need to guide treatment decisions.
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Helps distinguish unilateral from bilateral adrenal disease based on 18-oxocortisol levels, which are typically higher in aldosterone-producing adenoma than idiopathic adrenal hyperplasia. Use when evaluating 18-oxocortisol results during PA workup to guide subtype classification after a positive ARR.
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Azure AI Content Safety SDK for Python. Use for detecting harmful content in text and images with multi-severity classification.
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Expert-level geotechnical engineering covering soil classification, shear strength, consolidation, foundation design, slope stability, and retaining structures.
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Check proposed stack, data flows, cloud choices, and delivery controls against declared enterprise policies, compliance frameworks, and security controls. Trigger at R2/R3 risk classification, before locking architecture decisions, or when the operating profile names a governance pointer.
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Use when creating or editing a rule in src/rules/ — trigger wording, always vs auto classification, size budget — even when the user just says 'add a rule for X'.
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Run an infrastructure-first security audit of a repository - secrets archaeology, dependency supply chain, CI/CD pipeline, LLM/AI attack surface, agent skill supply chain, OWASP Top 10, STRIDE threat model, and data classification - with a confidence gate and a pre-emit verification gate that suppress speculative findings. Use when asked for a security audit, threat model, pentest-style review, OWASP pass, or a pre-release security check. Not for reviewing a single diff - use requesting-code-review for that.
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Orchestrator for agent-flow. Runs one issue or task through Implementer, Reviewer and QA as separate processes, with mechanical risk classification, a review-round cap and escalation to Needs Me, ending in a PR. Use for /implement <issue> or when asked to take an issue end to end ("have an agent take issue
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Find, build, evaluate, and improve systems using decision models. Use for bounded classification, routing, ranking, Choice/Score/Noul, decision-model composition, evaluation harnesses, prompt/program hill climbing, and Software 3.0 workflows across software, business, organizations, and life. Separate models, code, and human judgment. TypeSafe Jev is the default hosted exemplar. Not for straightforward arithmetic, prose rewriting, or provider setup alone.
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Modelo de moderação especializado 7-8B do Meta para filtragem de entrada/saída de LLM. 6 categorias de segurança - violência/ódio, conteúdo sexual, armas, substâncias, automutilação, planejamento criminal. Precisão de 94-95%. Deploy com vLLM, HuggingFace, Sagemaker. Integra com NeMo Guardrails.
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Modelo da OpenAI que conecta visão e linguagem. Permite classificação de imagens com zero-shot, correspondência imagem-texto e recuperação cross-modal. Treinado em 400M pares imagem-texto. Use para busca de imagens, moderação de conteúdo ou tarefas visão-linguagem sem fine-tuning. Melhor para compreensão geral de imagens.
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Classifies professional profiles into buyer, influencer, user, decision-maker, founder, recruiter, or other personas. Use when the user provides profiles and wants persona labels with evidence and confidence. Must not infer sensitive personal attributes.
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Protected Health Information (PHI) and Personally Identifiable Information (PII) compliance patterns for healthcare applications. Covers data classification, access control, audit trails, encryption, and common leak vectors. Use when code touches PHI or PII in a healthcare system, or when auditing access control, audit trails, or leak vectors.
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Clinical Decision Support System (CDSS) development patterns. Drug interaction checking, dose validation, clinical scoring (NEWS2, qSOFA), alert severity classification, and integration into EMR workflows. Use when building clinical decision support — drug interaction checks, dose validation, clinical scoring, or alert severity.
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Implement project-consistent UI through page classification, bounded references, semantic tokens, skeleton-first delivery, and responsive screenshot QA. Use for frontend redesigns, dashboards, forms, settings, mobile pages, screenshot recreation, visual polish, or generic-looking generated UI.
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Comprehensive incident response framework from detection through resolution and post-incident review. Battle-tested SRE/DevOps practices: severity classification, timeline reconstruction, structured post-incident analysis. Use when declaring an incident, coordinating multi-team response during an outage, leading a post-mortem, or setting up on-call practices for a new service.
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