Results for “bolt”

Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

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Set measurement units and grid preferences, then open the Parts Library when the user chooses Set up for Bits & Bolts or asks for onboarding.

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Use when modeling hard surface in ZBrush 2026 (sci-fi helmet, weapon, prop, armor plates, mechanical parts, kitbash, vents, panel lines, bolts, concept to game asset), when using ZModeler, Dynamic Subdivision and creasing, Live Boolean, Knife, Clip, Slice or Trim curves, IMM, ArrayMesh, NanoMesh or Panel Loops, or when edges look razor sharp, a Make Boolean Mesh fails or leaves holes, planes look wobbly, Mirror And Weld erased an edit, or ZRemesher ruins a hard-surface part.

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Turns an idea into a working, user-testable prototype with AI builders (Lovable, v0, Bolt, Replit, Cursor, Claude Code) and gets you unstuck when the tool breaks. Produces a Prototype Brief with a build-prompt pack, a debugging log and a user-test plan. Use for 'vibe coding', 'build a prototype', 'prototype this feature', 'Lovable prompt', 'my AI builder is stuck', 'prototype instead of a PRD', or 'demo for users'. Draws on 44 Lenny's Podcast guests incl. Lazar Jovanovic, Zevi Arnovitz and Guillermo Rauch.

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Route DGL graph learning tasks across graph APIs, datasets, message passing, GraphBolt, distributed tools, and DGL-Go workflows.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Proteina-Complexa flow-based protein backbone generation with fold-conditioned sampling guidance. Use this skill when: (1) Generating de novo protein backbones with hierarchical fold conditioning, (2) Exploring long-chain backbone generation beyond standard diffusion baselines, (3) Using NVIDIA Proteina-style flow matching workflows for controllable backbone design, (4) Comparing flow-based backbone generation against RFdiffusion or BoltzGen, (5) Prototyping fold-guided backbone campaigns before sequence design. This skill is based on the public NVIDIA Digital Bio Proteina project and uses "Proteina-Complexa" as the BioClaw-facing skill label. For sequence design after backbone generation, use proteinmpnn or solublempnn. For QC thresholds, use protein-design-qc.

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Structure similarity search with Foldseek. Use this skill when: (1) Finding similar structures in PDB/AFDB databases, (2) Structural homology search, (3) Database queries by 3D structure, (4) Finding remote homologs not detected by sequence, (5) Clustering structures by similarity. For sequence similarity, use uniprot BLAST. For structure prediction, use chai or boltz.

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ESM2 protein language model for sequence scoring, embeddings, and plausibility checks. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai1-structure-prediction or boltz-structure-prediction. For QC thresholds, use protein-design-qc.

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ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc.

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Binder design ranking using ipSAE (interprotein Score from Aligned Errors). Use this skill when: (1) Ranking binder designs for experimental testing, (2) Filtering BindCraft or RFdiffusion outputs, (3) Comparing AF2/AF3/Boltz predictions, (4) Predicting binding success rates, (5) Need better ranking than ipTM or iPAE. For structure prediction, use chai or alphafold. For QC thresholds, use protein-qc.

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Apply when integrating a new requirement into an existing design. Redesign as if the requirement had been a foundational assumption from day one, instead of bolting it on.

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Use when working with Neo4j command-line tools — neo4j-cli (modern unified CLI — Cypher via Bolt, schema inspection, Aura management, Docker containers, credential management, agent skill catalog install; install with curl -sSfL https://neo4j.sh/install.sh | bash), neo4j-admin (backup, restore, import, memory sizing), cypher-shell (ad-hoc queries, scripting, CI/CD), or neo4j-mcp (quick MCP server install). Does NOT cover Cypher query authoring — use neo4j-cypher-skill. Does NOT cover driver upgrades — use neo4j-migration-skill. Does NOT cover full MCP editor configuration — use neo4j-mcp-skill.

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Neo4j .NET Driver v6 — IDriver lifecycle, DI registration (singleton), ExecutableQuery fluent API, ExecuteReadAsync/ExecuteWriteAsync managed transactions, IResultCursor (FetchAsync/ ToListAsync), record value access (.Get<T>/As<T>), null safety, UNWIND batching, temporal types, await using, EagerResult, object mapping, CancellationToken, error handling, and common traps. Use when writing C# or .NET code connecting to Neo4j. Also triggers on Neo4j.Driver, IDriver, ExecutableQuery, ExecuteReadAsync, ExecuteWriteAsync, IResultCursor, IAsyncSession, or any Bolt/Aura work in .NET/C#. Does NOT handle Cypher authoring — use neo4j-cypher-skill. Does NOT cover driver version upgrades — use neo4j-migration-skill.

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Neo4j JavaScript/TypeScript Driver v6 — driver lifecycle, executeQuery, managed transactions (executeRead/executeWrite), session.run, Integer handling, JSON serialization, record access, async/await patterns, TypeScript types, error handling, and connection setup for Node.js and browser. Use when writing JS/TS code that connects to Neo4j — neo4j.driver(), executeQuery, executeRead, executeWrite, session.run, neo4j.int, record.get, Integer, BookmarkManager, bolt://, neo4j+s://. Does NOT handle Cypher query authoring — use neo4j-cypher-skill. Does NOT cover driver version migration — use neo4j-migration-skill.

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Use when reading from or writing to Neo4j with Apache Spark or Databricks using the Neo4j Connector for Apache Spark 6.0 (org.neo4j.connectors:spark) or 5.x (org.neo4j:neo4j-connector-apache-spark). Covers SparkSession setup, DataFrame reads via labels/Cypher/relationship scan, DataFrame writes with SaveMode, node.keys for MERGE, relationship write mapping, partition and batch tuning, PySpark and Scala examples, Databricks cluster config, Databricks secrets for credentials, Delta Lake to Neo4j pipelines. Does NOT handle Cypher authoring — use neo4j-cypher-skill. Does NOT handle the Python bolt driver — use neo4j-driver-python-skill. Does NOT handle GDS algorithms — use neo4j-gds-skill.

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Email/SMS lifecycle and deliverability framework for SMB Product-Builder products that send transactional or lifecycle messages (booking reminders, CRM sequences, receipts, win-back). Codifies provider selection (Resend/Postmark/Twilio/SendGrid), domain auth (SPF/DKIM/DMARC), consent and compliance (TCPA, CAN-SPAM, CASL, quiet hours, double opt-in), suppression-list discipline, and the transactional-vs-marketing split. Applied by integrations-engineer and senior-dev whenever a feature sends messages — so deliverability and consent are designed in, not bolted on after the first spam complaint.

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Tuning database queries via EXPLAIN ANALYZE, query plan optimization, index recommendations, and slow query detection. Not for schema/migrations (Schema) or non-DB performance (Bolt).

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Optimizing frontend (re-render, memoization, lazy loading) and backend (N+1, indexing, caching, async) performance, plus continuous auto-tuning loops for GC/threadpool/cache/worker settings.

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Monitors ArgoCD application sync status via the ArgoCD REST API and gRPC gateway. Detects drift between desired and live Kubernetes manifests and triggers Slack notifications through the Slack Bolt SDK.

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Multi-backend database security auditor. Audits Supabase, Firebase (Firestore/RTDB/Storage/Functions/Remote Config), MongoDB (self-hosted + Atlas), self-hosted PostgreSQL, and self-hosted MySQL for RLS/rules misconfigurations, exposed credentials, auth bypasses, MongoBleed (CVE-2025-14847), pgBouncer CVE-2025-12819, mysql_native_password drift, ghost auth, and storage exposures. Use this skill whenever the user mentions database security, RLS or rule audits, security review, penetration testing a vibe-coded app, checking if their DB is exposed, hardening a backend, fixing security rules, or auditing apps built with Lovable/Bolt/Replit/Cursor/Claude Code on any of these backends. Trigger on phrases like 'is my app secure', 'check my database', 'audit my Firebase', 'audit my MongoDB', 'audit my Postgres', 'audit my Supabase', 'is my DB exposed', or any cross-backend variant ('audit my full stack').

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Audit any Supabase project for security vulnerabilities, RLS misconfigurations, exposed API keys, auth bypasses, and storage issues. Use this skill whenever the user mentions Supabase security, RLS policies, database security audit, security review, penetration testing a Supabase app, checking if their database is exposed, hardening their Supabase project, fixing RLS, or anything related to securing a Supabase or vibe-coded application. Also trigger when the user asks about securing apps built with Lovable, Bolt, Replit, Cursor, or any AI coding tool that uses Supabase as a backend. Even if the user just says 'is my app secure' or 'check my database' and their project uses Supabase, use this skill. (DEPRECATED: this skill is a backwards-compat shim. Prefer the multi-backend `database-sentinel` skill, which covers Supabase plus Firebase, MongoDB, self-hosted Postgres, and self-hosted MySQL.)

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Evaluates bolt-on acquisitions for existing platforms with strategic fit, synergy quantification, and return contribution analysis. Use when screening add-on targets, building platform acquisition strategies, or modeling tuck-in economics.

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Expert-level Slack platform development using Bolt SDK — build Slack apps with slash commands, interactive components (buttons, modals, shortcuts), home tabs, event subscriptions, workflows, Socket Mode, and Block Kit. Use for building Slack bots, workflow automation, and rich interactive Slack experiences.

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