109 skills · sorted by relevance
Explain trained machine learning models through feature attribution, local explanations, and behavior summaries. Use as an explicit/manual helper once a model already exists, not for training ownership, leakage auditing, or general ML strategy selection.
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Activate when developers have latent caching needs: slow API responses, database read bottlenecks, DynamoDB throttling or cost, RDS/Aurora scaling pressure, Bedrock latency or cost, or adding a cache; activate when working with Redis, Valkey, Memcached, or any in-memory data store, cache-aside patterns, session stores, rate limiting, leaderboards, counters, streams, queues, pub/sub, distributed locks, feature flags, shopping carts, or other caching strategies. Activate for GenAI and ML retrieval: vector similarity search for low-latency retrieval, semantic caching, RAG, LLM response caching, embedding stores, AI agent memory, recommendation, personalization. Activate for ElastiCache lifecycle: provisioning (serverless or node-based), engine selection, CloudFormation/CDK/Terraform IaC, VPC connectivity, TLS, RBAC, IAM auth, Global Datastore, monitoring, troubleshooting, cost optimization, and migration from self-managed Redis. Do not trigger for browser caches, CDN/CloudFront, HTTP Cache-Control, CPU caches.
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Selects, deploys, and customizes AI models on Amazon SageMaker. Training or Processing jobs, fine-tuning (SFT/DPO/RLVR/RLAIF), model selection, dataset preparation, evaluation, SageMaker or Bedrock deployment, inference optimization and endpoint diagnostics. Covers the full lifecycle from planning through production. Use when fine-tuning models on SageMaker, choosing which base model to customize, fine-tune, or deploy from SageMaker JumpStart or Hub, SageMakerPublicHub, or the SageMaker public model catalog, transforming or validating training data, evaluating model quality, deploying or optimizing endpoints, configuring IAM/S3 for training, or managing SageMaker Managed MLflow. Use for endpoint health, failures, latency, logs, metrics, errors. Covers Serverless Model Customization, Nova and OSS deployment paths, and PySDK v3. NOT for Ground Truth labeling, Feature Store, or general-purpose AWS infrastructure.
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Create award-winning, immersive web experiences at the level of Awwwards-featured agencies. Use when the user mentions "Awwwards quality", "make my site stunning", "scroll animations", "parallax storytelling", "cinematic web design", "portfolio site", or "brand experience". Also trigger when elevating a standard landing page into a memorable digital experience. Covers dramatic typography, purposeful motion, scroll-based composition, and performance-optimized animation. For foundational UI, see refactoring-ui. For type selection, see web-typography.
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Generates complete tumor immune-infiltration-guided bulk-transcriptome diagnostic biomarker and machine-learning research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, immune infiltration estimation, immune-linked module discovery, consensus feature selection, diagnostic modeling, nomogram construction, clinical association, and optional prognostic extension or validation. Covers five study patterns (immune-cell-first diagnostic workflow, immune-module-to-biomarker workflow, consensus-ML biomarker workflow, diagnostic-plus-prognostic hybrid workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, reference literature pack, and self-critical risk review.
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Use when performing PCA principal component dimensionality reduction on tabular numeric data. Supports command-line parameter input, automatic numeric feature selection, parameter validation, result directory creation, and CSV or TXT format result export.
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Use when running prognostic survival analysis on a clinical cohort with time-to-event data to estimate univariate and multivariable Cox proportional hazards models, export result tables, and generate forest plots. NOT for: nomogram construction, calibration curves, time-dependent ROC analysis, or model training/feature selection beyond the built-in univariate screening rule.
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Use when validating an existing prognostic risk signature on an external bulk expression cohort with survival outcomes, producing risk scores, Kaplan-Meier curves, risk distribution plots, heatmap, and time-dependent ROC curves. NOT for: model training, feature selection, nomogram construction, calibration analysis, or single-cell data.
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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
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Analyze signal spectra in MATLAB using nonparametric and parametric estimators. Use when computing frequency content, PSD, power spectrum, spectral peaks, bandwidth, or streaming spectral analysis. Covers pspectrum, pwelch, periodogram, pmtm, pburg, pmusic, rootmusic, plomb, poctave, spectrumAnalyzer, dsp.SpectrumEstimator. TRIGGER: FFT, PSD, power spectrum, spectral analysis, frequency content, bandwidth measurement, spectral leakage, window selection, streaming spectrum, periodicity, resolve close frequencies, multitaper. DO NOT TRIGGER: filter design, spectrogram/time-frequency, audio features.
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Running closed and open betas that produce real signal. Beta participant selection, structured feedback collection, beta-to-GA decision criteria, and the difference between soft-launch (no structure, no signal), kitchen-sink (everyone in, no actionable feedback), and structured beta (calibrated cohort, intentional feedback loops, clear graduation criteria). Triggers on beta program, alpha test, beta cohort, beta participant, beta feedback, beta to GA decision, design partner, early access program, closed beta, open beta, RC release. Also triggers when a feature is approaching launch and the team needs structured pre-GA validation, when prior betas produced noise rather than signal, or when the team has soft-launched before but wants more structured feedback this time.
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A platform decision framework for experimentation. When to use Statsig vs PostHog vs GrowthBook vs Optimizely vs Amplitude vs Eppo vs Kameleoon. How to migrate between them. How to coordinate when multi-platform is genuinely warranted. The decisions that compound for years and the ones you can defer. Triggers on which experimentation platform, choose Statsig vs PostHog, evaluate experimentation tools, switch experimentation platform, migrate from Optimizely, consolidate experimentation tools, multi-platform experimentation, experimentation platform decision, ab test platform selection, feature flag platform vs experiment platform, warehouse-native experiments, vendor lock-in experimentation. Also triggers when a team is asking about cost, governance, or migration cost across experimentation tools, or when an evaluation is starting.
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Use when designing a new Godot feature or system — guides scene tree planning, node type selection, and architectural decisions
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Generates an in-app feedback collection form with category selection, text input, optional screenshot attachment, device diagnostics, and smart routing — directing happy users to App Store reviews and unhappy users to support. Use when user wants feedback, bug reports, feature requests, or contact support forms.
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Use when starting feature work that needs isolation from current workspace or before executing implementation plans - creates isolated git worktrees with smart directory selection and safety verification
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Use when starting feature work that needs isolation from current workspace or before executing implementation plans - creates isolated git worktrees with smart directory selection and safety verification
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Creates isolated git worktrees with smart directory selection and safety checks. Use when starting isolated feature work.
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Compares PIA/DPIA methodologies: CNIL PIA tool, ICO DPIA template, NIST Privacy Framework, and ISO 29134. Provides methodology selection criteria based on regulatory jurisdiction, organisation maturity, processing complexity, and resource availability. Covers regulatory acceptance, tool features, and cross-methodology mapping. Keywords: PIA methodology, CNIL, ICO, NIST Privacy Framework, ISO 29134, DPIA comparison, assessment.
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Framework for evaluating and selecting Consent Management Platforms (CMPs). Covers TCF v2.2 certification requirements, Global Privacy Control support, multi-regulation compliance (GDPR, CCPA, LGPD), A/B testing capabilities, API integration options, reporting features, and a structured vendor comparison methodology.
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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
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End-to-end biomarker discovery workflow from expression data to validated biomarker panels. Covers feature selection with Boruta/LASSO, classifier training with nested CV, and SHAP interpretation. Use when building and validating diagnostic or prognostic biomarker signatures from omics data.
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Selects informative features for biomarker discovery using Boruta all-relevant selection, mRMR minimum redundancy, and LASSO regularization. Use when identifying biomarkers from high-dimensional omics data.
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Make technology decisions for every product capability by discovering existing assets, evaluating vendor-aligned options, and categorizing as Reuse/Extend/Build/Buy/Integrate/Research during PRD v0.5 Red Team Review. Handles both greenfield and brownfield contexts. Triggers on "tech stack", "build or buy?", "what technologies?", "technical decisions", "what do we reuse?", "existing stack", "vendor constraint", "IBM-first", "what tools do we need?", "evaluate solutions", "select tech stack". Consumes FEA- (features), SCR- (screens), RISK- (constraints). Outputs TECH- entries with decisions, rationale, and cross-references. Feeds v0.6 Architecture Design.
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Determine technologies needed to build the product, making build/buy/integrate decisions during PRD v0.5 Red Team Review. Handles both greenfield and brownfield contexts. Triggers on requests to select tech stack, evaluate technologies, make build vs. buy decisions, discover existing assets, or when user asks "what technologies?", "select tech stack", "build or buy?", "what do we reuse?", "existing stack", "technical decisions", "what tools do we need?", "evaluate solutions". Consumes FEA- (features), SCR- (screens), RISK- (constraints). Outputs TECH- entries with decisions, rationale, and trade-offs. Feeds v0.6 Architecture Design.
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