Results for “mutations”

Generates an offline operation queue with persistence, automatic retry on connectivity, and conflict resolution. Use when user needs offline-first behavior, queued mutations, or pending operations that sync when back online.

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Use when setting up Data Connect, writing GraphQL queries/mutations, configuring generated SDKs, handling offline, or applying security rules.

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Operately frontend data fetching with TanStack Query. Use when adding or changing page loaders, model hooks, Api.* calls, mutations, useLoadedData, Pages.useRefresh, or any web UI backend request. New code must use TanStack. When fixing or extending an existing surface, migrate that surface's API calls to TanStack in the same change.

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Operately test layout, naming (.projections.json), factories, feature/e2e steps, external query/mutation auth specs, and how to run Elixir/API/JS/EE tests. Use when adding, renaming, splitting, or reviewing tests; choosing where a test belongs; writing Factory/TurboCase/FeatureCase or ExternalApi QuerySpec/MutationSpec tests; or running make test / feature tests.

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Implement secure Next.js Server Actions for mutations, forms, and optimistic UI. Use when building actions, form flows, auth checks, or revalidation after writes.

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Assess tests for an identified code or test change, feature, PR or commit. USE FOR: review changed behavior or regression tests, prove pre-fix/missing behavior is detected, revision-bound red-green evidence. Polyglot. DO NOT USE without an identified change: hypothetical mutations or general suite blind spots (test-gap-analysis). Also exclude per-test readiness/A-F grades (grade-tests), coverage (coverage-analysis), new suites (code-testing), or mutation engines.

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Find caller-visible production changes existing tests would miss through pseudo-mutation analysis; verify candidates or close gaps only when requested. Includes read-only per-test composition for grading. Polyglot. USE FOR: would tests catch a bug, behavioral blind spots, surviving mutations. DO NOT USE FOR: concrete fix/feature revision proof (test-value-evidence); suite taxonomy (test-tagging); .NET coverage, Cobertura, plateaus or coverage-backed priorities (coverage-analysis); named CRAP (crap-score); new suites (code-testing); assertion/smell audits; mutation tools.

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Agent self-evolution system. Collects signals from user feedback, stores execution trajectories (golden + correction pairs), analyzes patterns, proposes mutations to workspace files, and generates HTML reports. Trigger with "/evolve" or when the user asks to improve agent behavior. Also use when the user says "remember this pattern", "don't do X again", or "that was a good approach, save it".

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Access COSMIC cancer mutation database. Query somatic mutations, Cancer Gene Census, mutational signatures, gene fusions, for cancer research and precision oncology. Requires authentication.

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Writes Convex queries, mutations, actions, and internal functions in the object form with args and returns validators, correct ctx usage, runtime boundaries, and error handling. Use when adding or changing anything in convex/*.ts that exports a function, or when deciding between query, mutation, and action.

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Production patterns for Convex apps and the rules the @convex-dev/eslint-plugin enforces: validators, indexes, idempotent mutations, avoiding OCC conflicts, thin function wrappers, error handling. Use when reviewing Convex code, asking whether a pattern is right, setting up ESLint, or fixing write conflicts and slow queries.

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Builds AI agents on the Convex agent component: threads, messages, tools that call queries and mutations, streaming, RAG with vector search, and workflows for multi step jobs. Use when adding a chat assistant, tool calling agent, or retrieval feature to a Convex app.

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Routes Convex work to the right builder skill and covers the handful of rules that apply everywhere: validators on every function, withIndex over filter, idempotent mutations, internal functions for scheduling. Use when a task mentions Convex and no more specific skill matches, or as the first stop before picking one.

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Cancer genomics (TCGA et al.) via cBioPortal REST API. Retrieve somatic mutations, CNAs, expression, clinical data (survival/stage/treatment) across thousands of studies. Use for TMB, oncoprints, survival analysis. For population frequencies use gnomad-database; for drug-gene interactions use opentargets-database.

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Query COSMIC for cancer somatic mutations, gene census, mutational signatures, drug resistance variants. REST API v3.1 supports gene/sample/variant queries; free registration. For germline use clinvar-database; for drug-target data use opentargets-database or chembl-database-bioactivity.

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Analyzes a repository and its test suite to generate customized mutation operators tailored to the project. Use this skill when setting up mutation testing, improving test quality, or generating project-specific mutants. Considers language constructs, business logic patterns, API calls, data types, and code complexity to produce effective mutation operators that maximize test sensitivity while avoiding trivial or equivalent mutations. Generates prioritized operator sets (high/medium/low value) with impact summaries. Triggers when users ask to generate mutation operators, customize mutation testing, analyze code for mutation opportunities, or create project-specific mutants.

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TanStack Query v5 (React Query) server state management. Use for data fetching, caching, mutations, or encountering v4 migration, stale data, invalidation errors.

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Validate test effectiveness with mutation testing using Stryker (TypeScript/JavaScript with Vitest or bun test via @hughescr/stryker-bun-runner) and mutmut (Python). Find weak tests that pass despite code mutations. Use to improve test quality.

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Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.

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Query ClinVar for clinical variant significance. Use when user asks about variant pathogenicity, genetic variants, clinical significance, or disease-causing mutations. Triggers on "clinvar", "pathogenic", "variant significance", "clinical significance", "disease variant", "mutation pathogenicity".

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You are an expert in Apollo Client, the comprehensive GraphQL client for React applications. You help developers fetch data with GraphQL queries and mutations, manage local and remote state with Apollo's normalized cache, implement optimistic UI updates, handle pagination, and configure authentication — providing a complete data management solution for GraphQL-powered apps.

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Build and configure a GraphQL API backed by Neo4j using @neo4j/graphql v7 (current) or v5 (LTS). Covers Neo4jGraphQL constructor, getSchema(), assertIndexesAndConstraints(), type definitions with @node, @relationship (IN/OUT/UNDIRECTED), @cypher for custom resolvers, @authorization/@authentication for JWT/JWKS security, auto-generated queries/mutations, OGM programmatic access, subscriptions via CDC, and Apollo Federation. Use when writing typeDefs, securing fields, or wiring Neo4j to Apollo Server. Does NOT handle raw Cypher outside resolvers — use neo4j-cypher-skill. Does NOT cover Spring Data Neo4j entity mapping — use neo4j-spring-data-skill.

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Analyze and design control flows and data structures. Produces compact ASCII tree diagrams showing triggers, call chains, payload shapes, state mutations, and re-render effects. Use when user asks to diagram, trace, visualize, or design a flow or data structure.

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Reviews React Router code for proper data loading, mutations, error handling, and navigation patterns. Use when reviewing React Router v6.4+ code, loaders, actions, or navigation logic.

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