626 skills · sorted by relevance
Find images in Aura Assets for design mockups and marketing, including backgrounds, architecture, and portraits. Get five direct image URLs per category, with guidance on resolution, aspect ratio, and cropping for different placements.
Turn percentage strings into numeric data, calculate the remaining share needed to reach 100%, and create stacked bar charts. Compare category composition across periods or groups and save the chart as a high-resolution image.
Count categories in a chosen data column after removing missing values and placeholder labels. Calculate each category’s share and create high-resolution charts combining counts, percentages, pie charts, and horizontal bars for distribution reports.
Analyze MSBuild binary logs and timing summaries to find why builds are slow. Identify costly reference resolution, code analysis, file copying, restore work, or serialized tasks, then prioritize improvements by their share of total build time.
Extend safe-output jobs, which execute agent-generated actions, to reference newly created issues through temporary IDs. The guide covers job dependencies, issue-number resolution, input validation, tests, and warning-based handling of unresolved references.
Write a firm, effective complaint letter that gets a resolution. Use when asked to write a complaint letter, complain to a company about a product/service, escalate poor service, or demand a refund/replacement. Produces a structured complaint — the facts, the impact, the specific resolution you want, and a deadline — in a firm, professional tone that's hard to ignore and easy to act on.
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Balances Hi-C contact matrices (ICE via cooler.balance_cooler, KR/SCALE/VC context), computes distance-decay expected with cooltools (expected_cis per-diagonal P(s), expected_trans scalar), builds observed/expected (O/E) matrices, and diagnoses polymer state from the P(s) log-derivative. Covers the within-matrix-vs-cross-sample distinction (balancing is NOT a normalizer), the equal-visibility assumption that CNV/aneuploidy violates (use raw counts for copy-number), cis-only balancing, mad_max/blacklist masking before balancing, multiplicative cooler weights vs divisive juicer weights, and the resolution-vs-depth budget. Use when balancing a .cool/.mcool, computing expected or P(s), making O/E matrices for compartments/loops, deciding ICE vs KR vs SCALE, choosing a resolution for a given depth, or troubleshooting NaN/all-NaN balanced matrices; route cross-sample comparison to hic-differential.
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Detects A/B chromatin compartments from balanced Hi-C contact matrices via eigenvector decomposition of the distance-normalized, Pearson-correlated cis matrix with cooltools (eigs_cis), then orients (phases) the compartment eigenvector against a GC or gene-density track so the active (A) sign is not arbitrary. Covers the eigenvector-is-a-choice problem (per-arm view_df to remove the centromere gradient; picking the eigenvector by max correlation with activity, not by eigenvalue), GC phasing with bioframe.frac_gc, resolution choice (100kb-1Mb), saddle plots and saddle_strength for compartmentalization strength, the cohesin-loss-strengthens-compartments result, subcompartments (SNIPER/Calder/dcHiC), and cross-condition compartment switching. Use when calling A/B compartments, computing E1/eigenvectors, phasing the eigenvector, building saddle plots, choosing a compartment resolution, quantifying compartment strength, or comparing compartmentalization across conditions.
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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.
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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2024 bioRxiv; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.
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Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3 (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.
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Expert blueprint for digital card games (CCG/Deckbuilders) including card data structures (Resource-based), deck management (draw/discard/reshuffle), turn logic, hand layout (arcing), drag-and-drop UI, effect resolution (Command pattern), and visual polish (godot-tweening, shaders). Use for CCG, deckbuilders, or tactical card games. Trigger keywords: card_game, deck_manager, card_data, hand_layout, drag_drop_cards, effect_resolution, command_pattern, draw_pile, discard_pile.
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Expert patterns for scaling mobile games to desktop including mouse/keyboard controls, increased resolution and graphical fidelity, expanded UI layouts, settings menus, window management, and platform-specific features. Use when creating desktop ports or cross-platform releases. Trigger keywords: mouse_controls, keyboard_shortcuts, resolution_scaling, graphics_settings, fullscreen_toggle, window_modes, Steam_integration, desktop_optimization.
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Expert blueprint for digital card games (CCG/Deckbuilders) including card data structures (Resource-based), deck management (draw/discard/reshuffle), turn logic, hand layout (arcing), drag-and-drop UI, effect resolution (Command pattern), and visual polish (godot-tweening, shaders). Use for CCG, deckbuilders, or tactical card games. Trigger keywords: card_game, deck_manager, card_data, hand_layout, drag_drop_cards, effect_resolution, command_pattern, draw_pile, discard_pile.
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Expert patterns for scaling mobile games to desktop including mouse/keyboard controls, increased resolution and graphical fidelity, expanded UI layouts, settings menus, window management, and platform-specific features. Use when creating desktop ports or cross-platform releases. Trigger keywords: mouse_controls, keyboard_shortcuts, resolution_scaling, graphics_settings, fullscreen_toggle, window_modes, Steam_integration, desktop_optimization.
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Shared density-resolution contract for wave skills. Canonical detail on the D12 cascade, density resolver call, ad-hoc override workflow, and DocumentationDensityEvent telemetry emission. Referenced from nw-discover / nw-discuss / nw-design / nw-devops / nw-distill / nw-deliver.
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在Python 2.7环境下解析Windows目录链接（Junction）或符号链接的真实物理路径。提供基于PyWin32 API和PyQt4/5 QProcess调用cmd命令的两种解决方案，解决os.path.realpath失效及输出解析问题。
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Draft, confirm, and post replies to GitHub PR review threads. Handles per-category reply formatting, re-fetches thread resolution state so auto-resolved threads are skipped, posts via GraphQL, resolves threads whose entry carries a resolution reason, and dismisses the code-scanning alert behind a thread whose entry carries an alert number. Use when the user asks to "reply to PR threads", "post PR thread replies", or "draft PR reply messages".
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Implement privacy-preserving record linkage across datasets using Bloom filter encoding, secure hash matching, threshold tuning for precision and recall, and false positive management. Enables entity resolution without exposing raw personally identifiable information between parties.
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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2025 Nat Genet; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.
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Knowledge graph specialist for entity and causal relationship modelingUse when "knowledge graph, graph database, falkordb, neo4j, cypher query, entity resolution, causal relationships, graph traversal, graph-database, knowledge-graph, falkordb, neo4j, cypher, entity-resolution, causal-graph, ml-memory" mentioned.
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Audio and video processing with ffmpeg. Use when: user asks to convert, trim, merge, compress, or transcode video or audio files; extract audio from video; create GIFs or animated WebP from video; add subtitles or watermarks to video; change video resolution, framerate, or codec; normalize audio loudness; extract frames from video; concatenate clips; create thumbnails from video; strip or add audio tracks; convert between audio formats (MP3, AAC, FLAC, Opus, WAV); adjust volume; apply video filters; stabilize shaky video; generate waveform or spectrum visualizations; probe media file metadata. Triggers on 'ffmpeg', 'video', 'audio', 'transcode', 'MP4', 'MKV', 'WebM', 'MP3', 'AAC', 'FLAC', 'Opus', 'WAV', 'GIF from video', 'extract audio', 'add subtitles', 'video to gif', 'compress video', 'trim video', 'merge videos', 'normalize audio', 'framerate', 'resolution', 'bitrate', 'codec', 'ffprobe', 'waveform', 'spectrogram'.
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Dispute resolution, forensic investigation, and risk assessment for autonomous AI agent transactions. Reconstruct provenance chains, adjudicate fault, generate actuarial risk profiles for agent insurance. The accountability layer of the Agent Trust Stack.
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Draft board resolutions, consent documents, and meeting minutes. Use when asked to "draft a board resolution", "write board minutes", or "prepare a board consent".
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