Results for “dma”

Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

The English summary is being prepared. Showing the original description.

Survey a codebase's animation and motion code as a senior motion advisor, then produce a prioritized audit and self-contained implementation plans for other agents (or cheaper models) to execute. Read-only on source code — it plans improvements, it does not apply them. Use when the user asks to "improve the animations", "audit the motion", "make this app feel better", or wants a roadmap of animation fixes rather than a review of a single diff.

The English summary is being prepared. Showing the original description.

Answers "can CARLA do X here, and is there a vetted procedure for it" before you promise anything, and detects client/server/tree version skew — a support matrix over the whole collection (covered by a skill / works but undocumented / present but untested / broken or removed), an index of the features that are verified BROKEN on 0.10.0 (gbuffers crash the server, map layers do nothing, Landmark.waypoint is None, standalone asset packages are gone), and a probe that reports what this machine's build flags and running server actually offer. Use when the user asks whether CARLA supports something, when a feature has no skill, when a UE4 tutorial's steps do not exist, or before improvising a procedure.

The English summary is being prepared. Showing the original description.

Three.js (three, WebGL / WebGPU 3D グラフィクス) r186 リファレンス。 Scene, Group, PerspectiveCamera, OrthographicCamera, WebGLRenderer, WebGPURenderer, RenderPipeline、 BufferGeometry, BufferAttribute, StorageBufferAttribute, Mesh, InstancedMesh, SkinnedMesh、 MeshStandardMaterial, MeshPhysicalMaterial, ShaderMaterial, node-materials (TSL)、 DirectionalLight, SpotLight, PointLight, AmbientLight, PMREMGenerator、 GLTFLoader, FBXLoader, DRACOLoader, TextureLoader、 AnimationMixer, AnimationClip, AnimationAction, KeyframeTrack, Timer、 AudioListener, PositionalAudio、 Vector3, Matrix4, Quaternion, Euler, Color, Box3, Raycaster、 OrbitControls, TransformControls, WebXRManager。

The English summary is being prepared. Showing the original description.

Figma REST API / Plugin API / Widget API / Code Connect / MCP Server / Dev Mode リファレンス OAuth / PAT / Plan Access Token, files, folders, variables, VariableComposedColor, webhooks, SCIM, Dev Resources, activity-logs, library-analytics FrameNode, TextNode, ComponentNode, figma.variables, figma.codegen, figma.ui, textWrapStyle, variable fonts Widget useSyncedState, useSyncedMap, usePropertyMenu, AutoLayout Code Connect template files (.figma.ts) / legacy parser / custom parsers / register / Storybook (React / SwiftUI / Compose / HTML) MCP Code to Canvas, Write to Canvas, html_to_figma, generate_image, get_motion_context, generative plugins / shaders, Figma Weave

The English summary is being prepared. Showing the original description.

Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

The English summary is being prepared. Showing the original description.

Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

The English summary is being prepared. Showing the original description.

Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coordinates when sequence identity is below the twilight zone or remote-homology detection is required. Use when sequence MSA fails (<25% identity), when the dark proteome is the target, when AlphaFoldDB / ESM Atlas search is needed, or when structural superposition is the goal.

The English summary is being prepared. Showing the original description.

Auri: assistente de voz inteligente (Alexa + Claude claude-opus-4-20250805). Visao do produto, persona Vitoria Neural, stack AWS, modelo Free/Pro/Business/Enterprise, roadmap 4 fases, GTM, north star WAC e analise competitiva.

The English summary is being prepared. Showing the original description.

Prepare, validate, inspect, and edit EcoSIM soil management inputs using soil_mgmt_in NetCDF, editable Excel workbooks, and optional JSON files. Use when checking fertilizer, tillage, or irrigation management data; converting soil-mngt NetCDF to Excel for editing; converting edited Excel back to JSON or NetCDF; decoding fertf/tillf/irrigf selector variables; or validating EcoSIM ReadManagementMod.F90 soil-management inputs.

The English summary is being prepared. Showing the original description.

Create complete specs (requirements, design, tasks) for all features in roadmap.md using parallel sub-agent dispatch by dependency wave.

The English summary is being prepared. Showing the original description.

Bayer 抖动黑白点阵的小红书封面 / 杂志感海报 / 独立刊物封面模板 — 黑底 + Canvas 真做 Bayer 8×8 有序抖动把任意图片转成纯黑白点阵 + 上下双向 vignette + 杂志栏目式四角文字（刊号 / 栏目 / wordmark / credit）+ Noto Sans JP Black 中文超大粗黑标题 2×2 网格 + 中心方括号期号。4 套版式骨架（单图封面 / 上图下字 / 系列三联 / 内页长文），容器查询 cqh 适配任意尺寸。触发：用户要"点阵感 / dither / 1-bit / 黑白颗粒 / 小红书封面 / Vol 期号海报 / 独立刊物 / 报纸印刷感"。NOT 多区块产品页，NOT 彩色海报。

The English summary is being prepared. Showing the original description.

Use when the user wants a PRD exported — 'exportar o PRD', 'gerar o prd.json', 'criar issue com o PRD', 'export PRD to GitHub' — as canonical JSON or as a single GitHub issue. Do NOT use to publish a roadmap with many issues (prd-publish).

The English summary is being prepared. Showing the original description.

Use when the user asks which PRDs exist — 'listar PRDs', 'quais PRDs temos', 'list PRDs' — with status, version, roadmap state and GitHub Project. Read-only.

The English summary is being prepared. Showing the original description.

Cria, atualiza, comenta, fecha e reabre issues do GitHub e gerencia as tarefas de um GitHub Project — mover Status, editar campos, sub-issues e dependências "blocked by", inclusive em lote. Use quando o usuário disser "criar issue", "abrir uma issue", "fechar a issue #12", "reabrir", "comentar na issue", "atribuir para", "mover para Em andamento", "marcar como concluída", "bloqueada por", "sub-issue", "o que está bloqueando", "tarefas do project", "fechar as tasks da feature", ou citar #123 num repo GitHub. Não use para criar um Project novo (skill github-project) nem para publicar um roadmap inteiro (skill github-publish).

The English summary is being prepared. Showing the original description.

Use quando o usuário perguntar o estado da integração com o GitHub — 'status do github', 'qual project está configurado', 'o que já foi publicado' — gh, scopes, repo, Project e roadmaps publicados. Somente leitura.

The English summary is being prepared. Showing the original description.

Use when a product requirement, PRD, or executable roadmap is requested, or when an approved requirement needs decomposing into phases, epics, features and tasks

The English summary is being prepared. Showing the original description.

When the user wants to plan a content strategy, decide what content to create, or figure out what topics to cover. Also use when the user mentions "content strategy," "what should I write about," "content ideas," "blog strategy," "topic clusters," "content planning," "editorial calendar," "content marketing," "content roadmap," "what content should I create," "blog topics," "content pillars," or "I don't know what to write." Use this whenever someone needs help deciding what content to produce, not just writing it. For writing individual pieces, see copywriting. For SEO-specific audits, see seo-audit. For social media content specifically, see social-content.

The English summary is being prepared. Showing the original description.

Build a personalized learning roadmap with milestones and practice checkpoints

The English summary is being prepared. Showing the original description.

Evaluate any project, product, or system's claims against its actual implementation — scoring each claim for truth, identifying architectural gaps, assessing competitive positioning, proposing creative solutions, and producing an actionable roadmap. Load when the user asks to evaluate claims, reality-check a project, assess what this project actually does vs what it says, validate product claims, or score a system's credibility. Also triggers on "is this real", "does this work as claimed", "evaluate this project", "assess the gap between claims and reality", "how credible is this", "investor assessment", "score these claims", or "what's real vs marketing".

The English summary is being prepared. Showing the original description.

Create a detailed, step-by-step implementation plan for a feature or project. Load when the user asks to plan a feature, create a technical roadmap, break down a PRD into tasks, design an implementation strategy, or sequence engineering work. Also triggers on "how should we build this", "implementation plan for", "technical breakdown", "task list for", or any request to turn a high-level requirement into a concrete execution plan. Supports phased rollouts, architecture-first, and MVP-focused planning.

The English summary is being prepared. Showing the original description.

Prisma Client API reference covering model queries, filters, operators, and client methods. Use when writing database queries, using CRUD operations, filtering data, or configuring Prisma Client. Triggers on "prisma query", "findMany", "create", "update", "delete", "$transaction".

The English summary is being prepared. Showing the original description.

Auri: assistente de voz inteligente (Alexa + Claude claude-opus-4-20250805). Visao do produto, persona Vitoria Neural, stack AWS, modelo Free/Pro/Business/Enterprise, roadmap 4 fases, GTM, north star WAC e analise competitiva.

The English summary is being prepared. Showing the original description.

Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

The English summary is being prepared. Showing the original description.