Results for “character”

Use this skill when the user requests to generate, create, imagine, or visualize images including characters, scenes, products, or any visual content. Supports structured prompts and reference images for guided generation.

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Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.

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Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.

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Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.

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Extracts and assigns COSMIC v3.4 mutational signatures (84 SBS / 11 DBS / 18 ID / 24 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.

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Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.

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Expert in cluttering -- the lesser-known fluency disorder characterized by rapid/irregular speech rate, excessive disfluencies, and frequent ADHD comorbidity. Covers differential diagnosis from stuttering, assessment protocols, therapy approaches (rate control, self-monitoring, pragmatic awareness), technology-assisted intervention, and AI tools for people who clutter. Activate on 'cluttering', 'rapid speech disorder', 'speech rate too fast', 'speech disfluency not stuttering', 'disorganized speech', 'ADHD speech problems', 'cluttering vs stuttering', 'speech intelligibility', 'mazed speech', 'telescoping words'. NOT for stuttering-only treatment (overlap is common but they are distinct), hearing disorders, or voice disorders (pitch, resonance).

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AIエージェントのキャラクター定義ファイルを生成するスキル。ユーザーがキャラクター設定（名前、二つ名、年齢、属性、性格、支配の流儀、口癖、外見、絵文字など）を入力すると、それに基づいてIDENTITY.md、SOUL.md、USER.md、AGENTS.md、TOOLS.md、BOOTSTRAP.md、HEARTBEAT.mdの7つのファイルとavatar.pngを配置したキャラクターディレクトリを作成する。また、agent-identity/README.md にキャラクター情報とアバター画像を追加する。ユーザーが「キャラクターを作って」「新しいキャラクターを追加して」「○○っていうキャラクターのファイル作って」と言った時や、キャラクター設定を詳細に提供した時に使用する。

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既存キャラクター画像を、承認制でピクセルアートの正準画像へ変換し、3状態パイロット、クロマ前処理、状態間ジオメトリ検証、9状態生成、遷移QA、仮配置、アプリ内確認、ロールバック可能な正式配置まで行う。キャラクターからCodexペットを作る依頼に加え、ジャンプで小さくなる、状態ごとに身長が変わる、足元が跳ねる、クロマ縁が出る、アニメーションを修復したい依頼で使用する。

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This skill should be used when the user wants to "test a claim against data", "validate an empirical hypothesis", "refine a model/theory with evidence", "characterize a pattern and verify it", "演繹と帰納で検証", "仮説をデータで検証して更新", "実例と反例で確かめる", "弁証法ループ", "主張を現物で裏取り", "傾向分析を検証して精緻化", or mentions iteratively updating a hypothesis by deriving predictions and testing them against a real corpus. NOTE: Use this for VALIDATING/REFINING an empirical claim or model against real data through a derive→test→update loop. Use strong-inference for debugging an UNKNOWN cause, and devils-advocate for adversarially stress-testing a DESIGN proposal.

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Amplify safe or boring designs to make them more visually interesting and stimulating. Increases impact while maintaining usability. Use when the user says the design looks bland, generic, too safe, lacks personality, or wants more visual impact and character.

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Use when writing recommendation letters, reference letters, or award nominations for students, postdocs, or colleagues. Invoke when user mentions recommendation letter, reference, nomination, letter of support, endorsement, or needs help with strong advocacy, comparative statements, or evidence-based character assessment.

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Comprehensive China A-share stock analysis covering fundamental analysis, technical analysis, policy impact assessment, and market-specific features (T+1 trading, price limits, northbound capital flow). Use when user asks about A股分析, Chinese mainland stocks, Shanghai/Shenzhen listed stocks, or needs analysis considering China market characteristics.

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Amplify safe or boring designs to make them more visually interesting and stimulating. Increases impact while maintaining usability. Use when the user says the design looks bland, generic, too safe, lacks personality, or wants more visual impact and character.

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Translates or rewrites Chinese text into English using a 'critical dialogue' tone, characterized by engaging questions, analytical commentary, and a conversational flow while preserving citations and facts.

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Guardian Angel gives AI agents a moral conscience rooted in Thomistic virtue ethics. Rather than relying solely on rule lists, it cultivates stable virtuous dispositions— prudence, justice, fortitude, temperance—that guide every interaction. The foundation is caritas: willing the good of the person you serve. From this flow the cardinal virtues as practical habits of right action and sound judgment. v3.0 introduced virtue-based disposition as the primary evaluation layer, providing deeper coherence than checklists alone. The agent's character becomes the safeguard. v3.1 adds: Plugin enforcement layer with before_tool_call hooks, approval workflows for ambiguous cases, and protections for sensitive infrastructure actions.

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Count words, characters, sentences, paragraphs, and reading time for any text using AceToolz.

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Creates optimized meta titles, descriptions, and URL suggestions based on character limits and best practices. Generates compelling, keyword-rich metadata. Use PROACTIVELY for new content.

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Detects ransomware encryption activity in real time using entropy analysis, file system I/O monitoring, and behavioral heuristics. Identifies mass file modification patterns, abnormal entropy spikes in written data, and suspicious process behavior characteristic of ransomware encryption routines. Activates for requests involving ransomware behavioral detection, entropy-based file monitoring, I/O anomaly detection, or real-time encryption activity alerting.

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