89 skills · sorted by relevance
Use when -O3 leaves a hot loop scalar, spills appear in assembly, or a PGO or BOLT deployment is planned or stalls. Not for machine lowering: use code-generation-and-backends.
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Use when a task needs the judgment of a Continuous Mining Machine Operator in underground coal — reading a methane monitor trend and deciding whether to de-energize, judging whether cumulative unbolted advance has hit the roof control plan's cut-depth limit, deciding whether a permissibility defect requires immediate shutdown in a gassy heading, diagnosing whether a shift's production shortfall traces to cutting rate or shuttle-car haulage, or deciding whether a "drummy" roof sound stops the cut.
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Add a macOS menu bar status indicator for NanoClaw. Shows a bolt icon with a green/red dot indicating whether NanoClaw is running, with Start, Stop, and Restart controls. macOS only.
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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.
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Apply when integrating a new requirement into an existing design. Redesign as if the requirement had been a foundational assumption from day one, instead of bolting it on.
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Add a macOS menu bar status indicator for NanoClaw. Shows a bolt icon with a green/red dot indicating whether NanoClaw is running, with Start, Stop, and Restart controls. macOS only.
The English summary is being prepared. Showing the original description.
Add a macOS menu bar status indicator for NanoClaw. Shows a bolt icon with a green/red dot indicating whether NanoClaw is running, with Start, Stop, and Restart controls. macOS only.
The English summary is being prepared. Showing the original description.
Use when the user uploads a screenshot of a hero section or landing page (or a URL/description of one) and wants a copy-paste-ready developer prompt to recreate it exactly in a tool like Lovable, Bolt, Replit, or Cursor. Produces prompts with exact hex colors, Tailwind classes, animation timing tuples, and component structure — not vague descriptions.
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Detects per-caller special-cases (bandaids) bolted onto shared infrastructure/common functions, and when two or more same-kind special-cases exist proposes generalizing the lower-level mechanism instead.
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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
The English summary is being prepared. Showing the original description.
Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.
The English summary is being prepared. Showing the original description.
Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
The English summary is being prepared. Showing the original description.
Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.
The English summary is being prepared. Showing the original description.
Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
The English summary is being prepared. Showing the original description.
Analyze multi-body contact. Use when user mentions parts touching, friction between surfaces, bolt-plate contact, press fit, or assembly with contact.
The English summary is being prepared. Showing the original description.
Add a macOS menu bar status indicator for NanoClaw. Shows a bolt icon with a green/red dot indicating whether NanoClaw is running, with Start, Stop, and Restart controls. macOS only.
The English summary is being prepared. Showing the original description.