Results for “estimation”

Production-grade Bayesian causal inference with PyMC, CausalPy, and DoWhy. Enforces DAG-first thinking, mandatory user checkpoints for assumptions, design-specific refutation, and defensible reporting with causal language guardrails. Trigger on: causal inference, causal effect estimation, treatment effects, counterfactuals, difference-in-differences (DiD), synthetic control, regression discontinuity (RDD), interrupted time series (ITS), instrumental variables (IV), propensity scores, DAGs, causal graphs, confounders, backdoor criterion, do-calculus, interventional distributions, pm.do(), pm.observe(), CausalPy, DoWhy, mediation analysis, refutation, sensitivity analysis, parallel trends, placebo tests, or any question of the form "does X cause Y" or "what is the effect of X on Y."

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Dense, machine-readable API reference for PyFixest — high-dimensional fixed-effects OLS/WLS/IV and Poisson (feols, fepois, feglm), clustered/robust standard errors, R-style formula syntax, and post-estimation. Use when writing or debugging Python fixed-effects regressions with the pyfixest package.

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Deterministic mathematical computation using SymPy. Use for ANY math operation requiring exact/verified results - basic arithmetic, algebra (simplify, expand, factor, solve equations), calculus (derivatives, integrals, limits, series), linear algebra (matrices, determinants, eigenvalues), trigonometry, number theory (primes, GCD/LCM, factorization), and statistics. Ensures mathematical accuracy by using symbolic computation rather than LLM estimation.

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Forecast Azure spend and price planned resources or workloads. WHEN: "forecast Azure spending", "project next month cost", "compare forecast to my planning target", "how much will Azure cost", "estimate VM cost", "compare storage tiers", "compare Azure regions", "retail price", "EA rate card", "negotiated pricesheet". DO NOT USE FOR: configured budget health or alerts, bill analysis, cost spikes, rightsizing, or commitments.

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Real-time depth map privacy transforms using Depth Anything v2 (CoreML + PyTorch)

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Peptide-spectrum matching and protein identification from MS/MS data. Use when identifying peptides from tandem mass spectra. Covers database searching, spectral library matching, and FDR estimation using target-decoy approaches.

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Species abundance estimation using Bracken with Kraken2 output. Redistributes reads from higher taxonomic levels to species for more accurate estimates. Use when accurate species-level abundances are needed from Kraken2 classification output.

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Taxonomic classification of metagenomic reads using Kraken2. Fast k-mer based classification against RefSeq database. Use when performing initial taxonomic classification of shotgun metagenomic reads before abundance estimation with Bracken.

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Perform differential expression analysis using edgeR in R/Bioconductor. Use for analyzing RNA-seq count data with the quasi-likelihood F-test framework, creating DGEList objects, normalization, dispersion estimation, and statistical testing. Use when performing DE analysis with edgeR.

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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.

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This skill should be used when analyzing sector rotation patterns and market cycle positioning. It fetches sector uptrend data from CSV (no API key required) and optionally accepts chart images for supplementary analysis. Use this skill when the user requests sector rotation analysis, cyclical vs defensive assessment, overbought/oversold identification, or market cycle phase estimation. All analysis and output are conducted in English.

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Manages Amazon DocumentDB end-to-end — serverless-on-8.0 cluster setup, TLS/VPC/driver config, flexible-schema and vector-search data modeling, MongoDB compatibility assessment, DMS-based migration, slow-query diagnosis, major version upgrades (4.0->5.0->8.0), Well-Architected reviews (41-check wa_review.py), cost estimation, and security hardening. Retrieve for every DocumentDB question and when the user asks to set up or migrate MongoDB to AWS — DocumentDB is AWS's MongoDB-compatible managed database. Triggers: JSON document store, document database, MongoDB on AWS, Nested fields, Lambda cannot connect, TLS handshake, VPC port 27017, IAM auth, Secrets Manager, encryption at rest, $graphLookup, flexible schema, COLLSCAN, compound index, DMS migration, CDC cutover, $vectorSearch, RAG, Global Clusters, DR replication, cost sizing, audit, health check, production-readiness.

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Design scalable distributed systems using structured approaches for load balancing, caching, database scaling, and message queues. Use when the user mentions "system design", "scale this", "high availability", "rate limiter", "design a URL shortener", "design Twitter", "design Uber", "design a news feed", "system design interview", "capacity planning", or "distributed architecture". Also trigger when estimating infrastructure requirements, choosing between microservices and monoliths, or designing for millions of concurrent users. Covers common system designs (TinyURL, feeds, chat) and back-of-the-envelope estimation. For data fundamentals, see ddia-systems. For resilience, see release-it.

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Train and run models on Tinker (Thinking Machines) — LoRA and full fine-tuning, SFT with correct loss masking, RL/RFT with group-relative advantages and importance sampling, agentic RL over multi-turn tool-using agents, inference via the SamplingClient or the OpenAI-compatible endpoint, checkpoint management and export, every hyperparameter, and cost estimation from the live price table. Use this skill whenever the user mentions Tinker, tinker://, TINKER_API_KEY, console.tinker.ai, or the tinker CLI; wants to fine-tune, SFT, RFT, or RL a model on Tinker; asks about Tinker models, context windows, LoRA rank, sampling params, loss functions (cross_entropy, importance_sampling, ppo, cispo, dro), Datum construction, forward_backward or optim_step; wants to sample from, download, resume, merge, or export a Tinker checkpoint; or asks what a Tinker run will cost. Whenever Tinker work is initialized in a project, this skill also creates a TINKER_PRICING.md there so prices sit next to the training code. Reach for it even on vague asks like "train a model on this data" or "get inference working" when Tinker is the platform in play.

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Plans and delivers a single project — scope, estimation, scheduling, critical path, tracking, and recovering when it slips. Use this to plan a project, build or challenge a schedule, estimate credibly, track progress meaningfully, or recover a project that is late.

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DiDi ride-hailing service skill. Supports taxi booking, price estimation, route planning (driving/transit/walking/cycling), order management, driver location tracking, and scheduled rides. Use when user expresses any transportation need including ride-hailing, route queries, or commuting.

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Performs epidemiological analyses including disease modeling (SIR/SEIR), outbreak investigation, risk factor identification, incidence/prevalence estimation, and causal inference from observational data; trigger when users discuss disease spread, public health data, or populat...

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Plans sample size estimation logic, power assumptions, feasibility checks, and fallback enrollment strategies for clinical and translational study protocols.

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Generates complete tumor immune-infiltration-guided bulk-transcriptome diagnostic biomarker and machine-learning research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, immune infiltration estimation, immune-linked module discovery, consensus feature selection, diagnostic modeling, nomogram construction, clinical association, and optional prognostic extension or validation. Covers five study patterns (immune-cell-first diagnostic workflow, immune-module-to-biomarker workflow, consensus-ML biomarker workflow, diagnostic-plus-prognostic hybrid workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, reference literature pack, and self-critical risk review.

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Generates complete two-sample Mendelian randomization research designs from a user-provided outcome, exposure or exposure family, and robustness direction. Use when a study centers on summary-statistics causal inference with instrument selection, harmonization, IVW-primary estimation, complementary estimators, sensitivity analyses, optional multivariable upgrades, and conservative evidence interpretation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Designs studies for predicting treatment response or resistance in biomedical and clinical research. Always use this skill when the user needs a treatment-response or resistance prediction study blueprint rather than a prognostic biomarker protocol, diagnostic test design, causal treatment-effect estimation, or a completed manuscript. Focus on responder definition, treatment context, baseline comparability, feature integration strategy, model development logic, validation architecture, and interpretation boundaries. Do not invent response rates, cohort size, assay readiness, regimen uniformity, literature support, or validation access.

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Use when estimating immune infiltration from bulk RNA-seq expression matrices with ssGSEA/GSVA, comparing case versus control groups, and generating downstream immune-score visualizations. NOT for single-cell RNA-seq, absolute cell proportion estimation, or clinical decision making.

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Design effective excitation signals (step tests) for system identification and parameter estimation in control systems.

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Use scipy.optimize.curve_fit for nonlinear least squares parameter estimation from experimental data.

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