Results for “spl”

Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

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Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

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Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

The English summary is being prepared. Showing the original description.

Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

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Agent fallback for CEngineClient_IsPlayingDemo (auto-generated, category: func). Locate CEngineClient_IsPlayingDemo in the CS2 engine module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CEngineClient_IsPlayingDemo, CEngineClient_IsPlayingDemo

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Agent fallback for CCSPlayerPawn_SprayPaint (auto-generated, category: func). Locate CCSPlayerPawn::SprayPaint in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_SprayPaint, CCSPlayerPawn::SprayPaint

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Agent fallback for CCSPlayerPawn_CreatePlayerPawnServices (auto-generated, category: vfunc). Locate CCSPlayerPawn::CreatePlayerPawnServices in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_CreatePlayerPawnServices, CCSPlayerPawn::CreatePlayerPawnServices

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Agent fallback for CCSPlayerController_SwitchTeam (auto-generated, category: func). Locate CCSPlayerController::SwitchTeam in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerController_SwitchTeam, CCSPlayerController::SwitchTeam

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Agent fallback for CCSPlayerPawn_ProcessSuicideAsKillReward-decompiles (auto-generated, category: func). Locate CCSPlayerPawn::ProcessSuicideAsKillReward in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_ProcessSuicideAsKillReward-decompiles, CCSPlayerPawn::ProcessSuicideAsKillReward

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Agent fallback for CCSPlayerController_vtable (auto-generated, category: func). Locate CCSPlayerController_vtable in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerController_vtable, CCSPlayerController_vtable

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Agent fallback for CCSPlayerPawn_OnTakeDamage (auto-generated, category: func). Locate CCSPlayerPawn_OnTakeDamage in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_OnTakeDamage, CCSPlayerPawn_OnTakeDamage

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Agent fallback for CCSPlayerPawn_ClientCommand (auto-generated, category: vfunc). Locate CCSPlayerPawn::ClientCommand in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_ClientCommand, CCSPlayerPawn::ClientCommand

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Agent fallback for CCSPlayerPawnBase_OnSetDormant (auto-generated, category: vfunc). Locate CCSPlayerPawnBase::OnSetDormant in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawnBase_OnSetDormant, CCSPlayerPawnBase::OnSetDormant

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Agent fallback for CCSPlayerPawn_Event_KilledOther (auto-generated, category: vfunc). Locate CCSPlayerPawn::Event_KilledOther in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_Event_KilledOther, CCSPlayerPawn::Event_KilledOther

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Agent fallback for CCSPlayerPawn_Event_Killed (auto-generated, category: vfunc). Locate CCSPlayerPawn::Event_Killed in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_Event_Killed, CCSPlayerPawn::Event_Killed

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Agent fallback for CCSPlayerPawnBase_CheckForIdle (auto-generated, category: vfunc). Locate CCSPlayerPawnBase::CheckForIdle in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawnBase_CheckForIdle, CCSPlayerPawnBase::CheckForIdle

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Agent fallback for CCSPlayerPawn_ProcessSuicideAsKillReward (auto-generated, category: func). Locate CCSPlayerPawn::ProcessSuicideAsKillReward in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_ProcessSuicideAsKillReward, CCSPlayerPawn::ProcessSuicideAsKillReward

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Agent fallback for CCSPlayerPawn_PostThink (auto-generated, category: vfunc). Locate CCSPlayerPawnBase::PostThink in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_PostThink, CCSPlayerPawnBase::PostThink

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Agent fallback for CCSPlayerPawn_OnSwitchWeapons (auto-generated, category: func). Locate CCSPlayerPawn::OnSwitchWeapons in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_OnSwitchWeapons, CCSPlayerPawn::OnSwitchWeapons

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Agent fallback for CCSPlayerPawn_HandleDropWeapon (auto-generated, category: func). Locate CCSPlayerPawn::HandleDropWeapon in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_HandleDropWeapon, CCSPlayerPawn::HandleDropWeapon

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Agent fallback for CCSPlayerPawnBase_vtable (auto-generated, category: func). Locate CCSPlayerPawnBase_vtable in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawnBase_vtable, CCSPlayerPawnBase_vtable

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Agent fallback for CCSPlayerStateDeathAnim_vtable (auto-generated, category: func). Locate CCSPlayerStateDeathAnim_vtable in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerStateDeathAnim_vtable, CCSPlayerStateDeathAnim_vtable

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Agent fallback for CCSPlayerPawnBase_CheckForIdleInternal (auto-generated, category: func). Locate CCSPlayerPawnBase::CheckForIdleInternal in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawnBase_CheckForIdleInternal, CCSPlayerPawnBase::CheckForIdleInternal

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Agent fallback for CCSPlayerPawn_vtable (auto-generated, category: func). Locate CCSPlayerPawn_vtable in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CCSPlayerPawn_vtable, CCSPlayerPawn_vtable

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