Results for “sample”

Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

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Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.

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Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

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Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.

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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

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Build, debug, optimize, and deploy ComfyUI workflows for diffusion image, video, and audio generation. Activate on: ComfyUI workflow, ComfyUI custom node, ComfyUI API, ComfyUI Manager, KSampler, FLUX in ComfyUI, Wan 2.2 ComfyUI, Hunyuan video ComfyUI, LTX video ComfyUI, IPAdapter, ControlNet ComfyUI, Kijai wrapper, ComfyDeploy, RunComfy, ComfyUI security, GGUF quantization, TeaCache, Nunchaku, ACE-Step ComfyUI, F5-TTS ComfyUI, subgraphs ComfyUI. NOT for: A1111/Forge/Invoke (different UIs), training pipelines from scratch, non-diffusion ML models, or general image-API integrations (use generative-video-2026 / generative-music-audio / media-gen-deployment).

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Derive a SET of simulation personas for an agent from product artifacts — backend payloads, UI screenshots, journey/product docs, and sample real user messages — instead of designing one persona by hand. Identifies who actually interacts with the agent and how they behave, then creates the personas via the CLI. Best for text/chat agents and for new agents with no interaction history. Use when the user says "make personas from these screenshots/payloads", "who are my users", "create a set of personas", "derive personas from my product", "build a persona library", or "I have backend data, turn it into personas".

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The Shape System — the content_ir kind registry for structured content. Use when adding, activating, or rendering a kind/shape, writing `__kind` JSON, kind schemas or samples, XML-tag/fence detection surfaces, kind components, workflow node input_kind/output_kind, or binding agent output to a kind.

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Calculate statistical significance for A/B tests. Sample size estimation, power analysis, and conversion rate comparisons with confidence intervals.

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The science of learning through controlled experimentation. A/B testing isn't about picking winners—it's about building a culture of validated learning and reducing the cost of being wrong. This skill covers experiment design, statistical rigor, feature flagging, analysis, and building experimentation into product development. The best experimenters know that every test, positive or negative, teaches something valuable. Use when "a/b test, experiment, hypothesis, statistical significance, sample size, feature flag, variant, control, treatment, p-value, conversion rate, test winner, split test, experimentation, testing, statistics, feature-flags, hypothesis, growth, optimization, learning, validation" mentioned.

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Design and analyze A/B tests, calculate statistical significance, and determine sample sizes for conversion optimization and experiment validation

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Look up Microsoft API references, find working code samples, and verify SDK code is correct. Use when working with Azure SDKs, .NET libraries, or Microsoft APIs—to find the right method, check parameters, get working examples, or troubleshoot errors. Catches hallucinated methods, wrong signatures, and deprecated patterns by querying official docs.

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Detects AI-generated deepfake audio used in voice phishing (vishing) attacks by extracting spectral features (MFCC, spectral centroid, spectral contrast, zero-crossing rate) and classifying samples with machine learning models. Supports batch analysis of audio files, generates confidence scores, and produces forensic reports. Activates for requests involving deepfake voice detection, vishing investigation, AI-generated speech analysis, voice cloning detection, or audio authenticity verification.

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Analyzes bootkit and advanced rootkit malware that infects the Master Boot Record (MBR), Volume Boot Record (VBR), or UEFI firmware to gain persistence below the operating system. Covers boot sector analysis, UEFI module inspection, and anti-rootkit detection techniques. Activates for requests involving bootkit analysis, MBR malware investigation, UEFI persistence analysis, or pre-OS malware detection.

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Analyzes malicious Linux ELF (Executable and Linkable Format) binaries including botnets, cryptominers, ransomware, and rootkits targeting Linux servers, containers, and cloud infrastructure. Covers static analysis, dynamic tracing, and reverse engineering of x86_64 and ARM ELF samples. Activates for requests involving Linux malware analysis, ELF binary investigation, Linux server compromise assessment, or container malware analysis.

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Detect sandbox evasion techniques in malware samples by analyzing timing checks, VM artifact queries, user interaction detection, and sleep inflation patterns from Cuckoo/AnyRun behavioral reports

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Perform static analysis of Android APK malware samples using apktool for decompilation, jadx for Java source recovery, and androguard for permission analysis, manifest inspection, and suspicious API call detection.

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Executes malware samples in Cuckoo Sandbox to observe runtime behavior including process creation, file system modifications, registry changes, network communications, and API calls. Generates comprehensive behavioral reports for malware classification and IOC extraction. Activates for requests involving dynamic malware analysis, sandbox detonation, behavioral analysis, or automated malware execution.

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Convert per-page styled HTML prototypes (stardust under stardust/prototypes/**, or claude-design / Mobirise / Relume / Lovable / v0 / Figma-derived pages, or JSX prototypes pre-rendered to HTML, often under samples/) into Edge Delivery Services (EDS / AEM) blocks and content pages, then deploy via DA. Each prototype section becomes one EDS block; the prototype's per-section CSS becomes that block's CSS scoped under the block class. Use when the user wants to lift styled per-page HTML prototypes into a working EDS site under blocks/ and content/.

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Creates a new project document in the Sanity studio. Use when the user wants to add a new portfolio project, a case study, or a work sample to the Projects collection.

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Implements accessible modals and drawers with focus trap, ESC to close, scroll lock, portal rendering, and ARIA attributes. Includes sample implementations for common use cases like edit forms, confirmations, and detail views. Use when building "modals", "dialogs", "drawers", "sidebars", or "overlays".

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Implements comprehensive observability with OpenTelemetry tracing, Prometheus metrics, and structured logging. Includes instrumentation plans, sample dashboards, and alert candidates. Use for "observability", "monitoring", "tracing", or "metrics".

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