Results for “bec”

Pick an icon strategy and produce a coherent icon set that doesn't look mass-produced. Solves the "Lucide everywhere" problem — every AI-generated UI uses the same 24px stroke-1.5 outline icons, which is the second-biggest vibecoded tell after Inter-on-purple-gradient. Generates custom SVG sets, tunes existing icon libraries to match archetype + typography, defines stroke weight, optical sizing, and corner-radius rules. Load when the user asks to pick icons, design an icon set, customize Lucide / Phosphor / Heroicons, generate SVG icons, make icons feel custom, says "the icons look generic", "design a custom icon system", "icons for this product", or when frontend-design routes here during icon craft. Sub-skill of frontend-design.

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Capture actionable learnings that emerge during conversation — when the agent or user discovers that a skill, a set of skills, or a process needs to be updated based on what's happening in the current chat. Sub-skill of the learn-from orchestrator. Load when the user says "we should update the skill for this", "this should be a skill rule", "add this as a gotcha", "the skill should know about this", "update the process for this", "remember this for next time", "this is important for the skill". Also triggers when the agent notices a skill's guidance was wrong or incomplete, a process step failed or was unnecessary, a new pattern emerged, a guardrail was missing, a workaround became a pattern, or a debugging session reveals a gap.

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Turn a chosen design direction into a canonical DESIGN.md plus production tokens that don't look vibecoded — state-level colors (8-step neutral ramp, rest/hover/active/ disabled, focus ring), APCA-checked contrast, typography, spacing/radius/motion/elevation, an icon strategy, and component contracts for the core atoms. Emits tokens in the project's stack format (shadcn HSL vars or Tailwind v4 @theme). Load when the user asks to build a design system, generate design tokens, create a DESIGN.md, set up a theme, design a color or type system, pick icons, or when frontend-design routes here. Replaces design-tokens-craft and icon-craft. Sub-skill of frontend-design. Reads DIRECTION.md first.

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Review a built frontend against its chosen direction, catch drift back to generic AI defaults, enforce state coverage, ethical patterns, UX heuristics, and polish, and check contrast with APCA (not the legacy WCAG ratio). Produces specific, prioritized fixes — never vibes-based feedback. Works with pasted screenshots or Playwright MCP automated capture. Load when the user asks to review a UI, audit a design, check if a frontend looks generic or vibecoded, evaluate visual quality or polish, says "review this UI", "is this design good", "audit my frontend", "does this feel like [product]", "design QA", or when frontend-design routes here. Sub-skill of frontend-design.

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Infer or annotate TCR antigen specificity by unsupervised clustering (TCRdist/tcrdist3, GLIPH2, clusTCR, GIANA) and database lookup (VDJdb, IEDB, McPAS-TCR), and rank candidates with supervised predictors (ERGO-II, NetTCR-2.x, pMTnet) under explicit caveats. Encodes the central truth that general TCR-epitope prediction for UNSEEN epitopes essentially does not work (collapses to near-random; IMMREP22, Grazioli 2022) because labeled data is dominated by a few immunodominant epitopes and there is no true negative set — so clustering for discovery is the honest task and de-novo binding needs wet-lab validation. Use when annotating TCR specificity or grouping a repertoire. Epitope/MHC context lives in mhc-binding-prediction.

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Predict B-cell and T-cell epitopes for vaccine antigen design and epitope mapping with BepiPred-3.0, DiscoTope-3.0, the IEDB tools, and EL-mode MHC presentation. Encodes the load-bearing asymmetry that T-cell epitope prediction is mature (it reduces to MHC presentation, AUC>0.9) while B-cell prediction is unreliable (linear predictors ~AUC 0.6 because ~90% of real epitopes are conformational) — so structure-based DiscoTope-3.0 on AlphaFold models is the only defensible B-cell path, propensity scales are obsolete, and NetChop is largely redundant on EL-trained models. Use when mapping epitopes or selecting vaccine antigens. MHC binding lives in mhc-binding-prediction.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Profiles a genome from raw reads BEFORE assembly with a k-mer spectrum (KMC or Jellyfish histogram), then models it with GenomeScope2 to estimate genome size, heterozygosity, repeat content, and ploidy, and Smudgeplot to infer ploidy from heterozygous k-mer pairs (diploid AB vs triploid AAB vs tetraploid AABB). Covers choosing k via Merqury best_k.sh, the k-mer-coverage vs sequencing-coverage confusion, reading het/repeat/contamination/organelle peaks, why noisy ONT must not be used for counting, and how the estimate becomes the NG50 denominator, the Flye -g value, the hifiasm --hom-cov/purge setting, and the 1.5-2x-too-big haplotig sanity check. Use when starting any de novo assembly, deciding whether short reads can work, estimating genome size for an unknown organism, diagnosing ploidy, or sanity-checking an assembly's size against expectation.

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Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.

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Build UpSet plots to visualize set intersections beyond 4 sets (where Venn fails) using ComplexUpset (modern, ggplot2-grammar) or the unmaintained UpSetR, with explicit cardinality vs degree sorting, attribute panels, and query highlighting. Use when comparing overlap across many gene sets, peak sets, variant lists, or any set membership matrix where Venn diagrams become illegible.

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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.

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Extracts and assigns COSMIC v3.4 mutational signatures (84 SBS / 11 DBS / 18 ID / 24 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.

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Use this skill when the user asks about US-Canada cross-border CMV operations — CVOR (Commercial Vehicle Operator's Registration), NSC (National Safety Code), Ontario / Quebec / BC specific rules, US carrier obtaining Canadian operating authority, FAST card for drivers, customs (CBSA), Health Canada hazmat, and how Transport Canada equivalents differ from US FMCSA. Reference USMCA + Transport Canada NSC 14.

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Audit or design server-side indexes, directories, reputations, or aggregates that are DERIVED from traffic a platform witnesses (chain heads, run verdicts, heartbeats, publish activity) so that consent gates the derivation, not merely the read: no shadow index over non-consenting principals, post-consent-only evidence windows, retention bounds and delete-propagation into derived rows, activity-oracle threat modeling, and audit-logged ranking discretion. Use when building a capability directory / whois from witnessed activity, a reputation ledger from settled outcomes, vitals aggregation across tenants, or any "the yellow pages can't lie because they index signatures" feature. Keywords: shadow index, derived index, consent gates derivation, activity oracle, phone book not a log, delist propagation, ranking weight audit, k-anonymous aggregate, subpoena surface. NOT for the consent-screen UX and scope-ladder mechanics themselves (use local-first-tenancy-boundary), reputation scoring math and Sybil economics (use agent-identity-continuity-reputation), or discovery-layer architecture L1/L2/L3 (use agent-discovery-directories-guilds).

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Audit a compliance-ladder design (C0-C6) and transcript-fidelity ladder (T0-T5) plus their adapter conformance fixtures — Codex, Claude Code, Cloudflare, Ollama/LM Studio, custom stdio/HTTP agents — for the two failure modes that make a C-badge or T-fidelity label a lie: the ladder disagreeing with itself across doc/schema/ui/probe surfaces, and a level being reachable by self-report because no daemon-witnessed negative probe actually tries to forge it. Use when designing or freezing a compliance ladder, wiring an adapter conformance probe suite, deciding whether a numeric C-badge or T-label is safe to ship, or investigating a self-attestation or observed-to-controlled bypass risk. NOT for auditing a cryptographic protocol or whitepaper for adversarial soundness (`redteam-review`), writing TLA+/formal invariants for a daemon monitor (`runtime-verification-for-agents`), or agent identity, successor linkage, and reputation across restarts (`agent-identity-continuity-reputation`).

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Rules for SKILL.md files that trigger, fit, and are proven. Use when creating a SKILL.md, rewriting its description, splitting an oversized SKILL.md, or editing one because an agent ignored, misread, or never fired it.

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The bar every automated test or guard must clear: green only when the real system works. Use when writing, fixing, or reviewing a test, mock, stub, fixture, snapshot, or self-test; adding a regression test for a bug; or about to call work done because tests pass.

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Guardian Angel gives AI agents a moral conscience rooted in Thomistic virtue ethics. Rather than relying solely on rule lists, it cultivates stable virtuous dispositions— prudence, justice, fortitude, temperance—that guide every interaction. The foundation is caritas: willing the good of the person you serve. From this flow the cardinal virtues as practical habits of right action and sound judgment. v3.0 introduced virtue-based disposition as the primary evaluation layer, providing deeper coherence than checklists alone. The agent's character becomes the safeguard. v3.1 adds: Plugin enforcement layer with before_tool_call hooks, approval workflows for ambiguous cases, and protections for sensitive infrastructure actions.

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Use this skill to create CodeTour .tour files — persona-targeted, step-by-step walkthroughs that link to real files and line numbers. Trigger for: "create a tour", "make a code tour", "generate a tour", "onboarding tour", "tour for this PR", "tour for this bug", "RCA tour", "architecture tour", "explain how X works", "vibe check", "PR review tour", "contributor guide", "help someone ramp up", or any request for a structured walkthrough through code. Supports 20 developer personas (new joiner, bug fixer, architect, PR reviewer, vibecoder, security reviewer, and more), all CodeTour step types (file/line, selection, pattern, uri, commands, view), and tour-level fields (ref, isPrimary, nextTour). Works with any repository in any language.

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Adopt a virtual Tesseract AI-native pet at animalhouse.ai. Four-dimensional. Stats wrap around. Hunger at 0 becomes hunger at 100. Feeding every 12 hours. Extreme tier creature.

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Detect compromised O365 and Google Workspace email accounts by analyzing inbox rule creation, suspicious sign-in locations, mail forwarding rules, and unusual API access patterns via Microsoft Graph and audit logs.

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Deploy AI and NLP-powered detection systems to identify business email compromise attacks by analyzing writing style, behavioral patterns, and contextual anomalies that evade traditional rule-based filters.

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Auditing Kubernetes cluster RBAC configurations to identify overly permissive roles, wildcard permissions, dangerous ClusterRoleBindings, service account abuse, and privilege escalation paths using kubectl, rbac-tool, KubiScan, and Kubeaudit.

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Parse Office 365 Unified Audit Logs via Microsoft Graph API to detect email forwarding rule creation, inbox delegation, suspicious OAuth app grants, and other indicators of account compromise.

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