1.1K skills · sorted by relevance
Frontend development guidelines for React/TypeScript applications. Modern patterns including Suspense, lazy loading, useSuspenseQuery, file organization with features directory, MUI v7 styling, TanStack Router, performance optimization, and TypeScript best practices. Use when creating components, pages, features, fetching data, styling, routing, or working with frontend code.
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Modern Angular UI patterns for loading states, error handling, and data display. Use when building UI components, handling async data, or managing component states.
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bu skill covers integrating Static Application Security Testing (SAST) tools—CodeQL and Semgrep—into GitHub Actions CI/CD pipelines. It addresses configuring automated code scanning on pull requests and pushes, tuning rules to reduce false positives, uploading SARIF results to GitHub Advanced Security, and establishing quality gates that block merges when high-severity vulnerabilities are Detected.
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Creates a protected page with Suspense loading pattern. Use when adding new pages that require authentication, creating dashboard pages, or setting up new routes.
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Configures 1Password CLI with direnv for fast, secure credential loading. Activates for: 1Password + direnv setup, slow secrets (>2 sec), .env.op files, op:// references, AWS credentials via env vars, --reveal flag issues, repeated biometric prompts, creating 1Password items programmatically, op item get errors. Not for: 1Password GUI usage, SSH keys (use 1Password SSH agent).
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Generate 3D models, textures, images, rig characters, animate them, and prepare for 3D printing using the Meshy AI API. Handles API key detection, task creation, polling, downloading, and full 3D print pipeline with slicer integration. Use when the user asks to create 3D models, convert text/images to 3D, texture models, rig or animate characters, 3D print a model, or interact with the Meshy API.
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Detects and analyzes process injection techniques used by malware including classic DLL injection, process hollowing, APC injection, thread hijacking, and reflective loading. Uses memory forensics, API monitoring, and behavioral analysis to identify injection artifacts. Activates for requests involving process injection detection, code injection analysis, hollowed process investigation, or in-memory threat detection.
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Performance optimization, profiling, caching strategies, lazy loading, bundle optimization, and monitoring. Use when optimizing application performance, reducing bundle size, implementing caching, or analyzing bottlenecks.
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Plan a user interview topic in PostHog — pick who to target (cohort, emails, or PostHog distinct IDs), draft what to ask about, and prepare the voice-agent context plus a question list. Use when the user asks to "talk to users", "check how users feel about X", "interview some customers", "set up a user interview", "run a user-research call", "find users to ask about Y", or otherwise wants qualitative feedback through a conversation. Walks the user through targeting (cohorts-list, persons-list, or accepting emails / distinct IDs directly), captures the topic, and prompts for agent context and questions before calling user-interview-topics-create. Cohort targeting is resolved to explicit emails/distinct_ids at create time — topics snapshot their audience and do not re-evaluate cohort membership later. Do NOT trigger when the user is uploading a recorded interview audio file (that's the separate UserInterview/transcript flow) or only browsing existing topics with user-interview-topics-list.
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Produce and interpret PCA, t-SNE, UMAP, and PHATE plots for high-dimensional omics data with rigor about which method preserves what (variance, local structure, manifold, transitions), hyperparameter sensitivity, and the well-documented limits of 2D embeddings. Covers PCA biplot/scree/loadings, t-SNE PCA initialization (Kobak-Berens 2019), UMAP n_neighbors/min_dist trade-offs, and the Chari-Pachter 2023 critique. Use when visualizing high-dimensional data — bulk PCA, single-cell embeddings, multi-omics integration projections.
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End-to-end spatial transcriptomics workflow for Visium/Xenium data. Covers data loading, preprocessing, spatial analysis, domain detection, and visualization with Squidpy. Use when analyzing spatial transcriptomics data.
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Scalable data processing for ML workloads. Streaming execution across CPU/GPU, supports Parquet/CSV/JSON/images. Integrates with Ray Train, PyTorch, TensorFlow. Scales from single machine to 100s of nodes. Use for batch inference, data preprocessing, multi-modal data loading, or distributed ETL pipelines.
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Build AI scientist systems with the ToolUniverse Python SDK for scientific research. Covers the 3 calling patterns (`tu.run` portable dict API, `tu.tools.X` function API, direct class instantiation), tool loading, batch execution, MCP server integration, and embedding-based tool search. Use for SDK programming, custom tool composition, benchmarking pipelines, and integrating ToolUniverse into research workflows.
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End-to-end clinical trial analysis workflow from CDISC SDTM/ADaM loading through ICH E9(R1) estimand-driven primary analysis to CONSORT 2025 regulatory-compliant reporting. Covers data preparation, FDA 2023 marginal vs conditional logistic regression, categorical tests with Boschloo, modern HTE/subgroup methods, missing-data sensitivity (MMRM, reference-based MI, Permutt tipping point), graphical multiplicity (Bretz-Maurer), survival analysis (Cox/RMST/competing risks) when applicable, and Table 1. Use when performing a complete analysis of clinical trial data.
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Install the ToolUniverse Claude Code plugin in one step — provides MCP server with 1000+ scientific tools, 120+ research skills, slash commands, hooks, and the research agent. Use for first-time plugin install, troubleshooting plugin not loading, verifying MCP server connection, listing API key requirements, or configuring auto-update.
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End-to-end multiome workflow for joint scRNA-seq + scATAC-seq analysis. Covers data loading, separate modality processing, and WNN integration with Seurat/Signac. Use when analyzing joint scRNA+scATAC data.
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Detect and auto-install missing ToolUniverse research skills. Checks common Claude Code/Cursor/Codex skill directories for the canary file, and installs any missing skills if none found. Use when the plugin's research skills aren't loading, when migrating between clients, or when verifying a skill installation.
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Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, MMTF) using RDKit and Open Babel with rigorous handling of aromaticity perception, stereochemistry, implicit/explicit hydrogens, kekulization, and salt/fragment separation. Use when loading chemical libraries, debugging parse failures, or preparing molecules for downstream standardization, descriptor calculation, or docking.
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Diagnose and fix UI performance across loading speed, rendering, animations, images, and bundle size. Use when the user mentions slow, laggy, janky, performance, bundle size, load time, or wants a faster, smoother experience.
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Add moments of joy, personality, and surprise through success states, empty states, loading moments, hover details, and celebratory polish once the fundamentals already work. Use when the user wants delight, charm, personality, or memorable micro-interactions—not when the main need is baseline cleanup or stronger visual impact.
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Next.js App Router 専用 API リファレンス（Pages Router / getStaticProps 等は非対応）。 Server Components, Server Actions, layout/page/loading/error ファイル規約, dynamic / parallel / intercepting routes, Metadata API (generateMetadata), Cache Components, use cache, Partial Prefetching, revalidatePath/revalidateTag/updateTag, catchError, next/root-params, ensureStatic, next/image・next/font・next/link, cookies/headers, useRouter, next.config.js, proxy（旧 middleware）。 プラットフォーム実行基盤・CDN・ISR インフラは vercel スキル参照。
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Loads, converts, and manipulates Hi-C contact matrices in cooler format (.cool/.mcool/.scool) and Juicer .hic, using cooler (Python + CLI), hic2cool, and hictk. Covers the single-resolution mcool URI (file.mcool::/resolutions/<bp>), the load-bearing divisive-vs-multiplicative weight-naming rule (KR/VC/VC_SQRT auto-divisive vs cooler's multiplicative weight), what survives .hic<->.cool conversion (FRAG matrices and norm vectors do not), raw-vs-balanced coarsening, the .pairs upper-triangle/chromsize-order contract, and chrom-naming/bin-table provenance. Use when loading a cooler, converting .hic to .mcool, selecting a resolution, building a cooler from pairs or a matrix, coarsening/zoomifying, importing Juicer norm vectors, or debugging all-NaN balanced matrices and chr1-vs-1 empty fetches.
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Reads, inspects, and writes Flow Cytometry Standard (FCS) files from conventional, spectral, and mass cytometry (CyTOF), and parses FlowJo/Cytobank/Diva workspaces. Covers FCS 2.0/3.0/3.1/3.2 internals ($PnE linear-vs-log, $DATATYPE, $SPILLOVER vs SPILL vs $COMP, $TIMESTEP), channel/parameter metadata, the silent linearize/truncate defaults, and R (flowCore, flowWorkspace, CytoML) plus Python (FlowKit, readfcs) readers. Use when loading flow or mass cytometry data, mapping detector channels to antibodies, extracting the event matrix, choosing a reader, or bridging FCS to the scanpy/AnnData ecosystem before preprocessing.
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Retrieve records from NCBI databases using Biopython Bio.Entrez (EFetch, ESummary). Use when downloading sequences, fetching GenBank/GenPept records, getting document summaries, parsing nested XML, navigating GI deprecation, choosing between rettype+retmode combinations, and parsing into Biopython SeqRecord/SwissProt objects. Covers nucleotide, protein, gene, pubmed, sra, gds, taxonomy, snp, clinvar.
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