1.1K skills · sorted by relevance
Investigate supply chain attack artifacts including trojanized software updates, compromised build pipelines, and sideloaded dependencies to identify intrusion vectors and scope of compromise.
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Analyzes malicious PDF files using PDFiD, pdf-parser, and peepdf to identify embedded JavaScript, shellcode, exploits, and suspicious objects without opening the document. Determines the attack vector and extracts embedded payloads for further analysis. Activates for requests involving PDF malware analysis, malicious document analysis, PDF exploit investigation, or suspicious attachment triage.
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Publication-quality physics plots — vector fields, streamlines, contour maps, 3D surfaces, phase space, spectrograms, and animations. Optimized for journal submission with LaTeX labels, proper colormaps, and multi-panel layouts.
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High-performance reinforcement learning framework optimized for speed and scale. Use when you need fast parallel training, vectorized environments, multi-agent systems, or integration with game environments (Atari, Procgen, NetHack). Achieves 2-10x speedups over standard implementations. For quick prototyping or standard algorithm implementations with extensive documentation, use stable-baselines3 instead.
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Production-ready reinforcement learning algorithms (PPO, SAC, DQN, TD3, DDPG, A2C) with scikit-learn-like API. Use for standard RL experiments, quick prototyping, and well-documented algorithm implementations. Best for single-agent RL with Gymnasium environments. For high-performance parallel training, multi-agent systems, or custom vectorized environments, use pufferlib instead.
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Orchestrates the full path from differential expression results to redundancy-collapsed functional enrichment: choose ORA vs GSEA, convert gene IDs per method, run enrichGO/enrichKEGG/enrichPathway/enrichWP or gseGO/gseKEGG (clusterProfiler, ReactomePA, rWikiPathways), and visualize. Use when a DESeq2/edgeR/limma result must become enriched GO terms, KEGG/Reactome/WikiPathways pathways, or a GSEA leading edge; when the input is a full ranking for all genes (GSEA, named decreasing vector) or only a pre-selected list (ORA plus a defensible background universe); or when assembling DE-to-pathway end to end. The DE list and ranking statistic come from differential-expression/de-results; per-method nuance lives in the pathway-analysis skills.
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Orchestrates an end-to-end MeRIP-seq / m6A-seq analysis from raw FASTQ to differential m6A peak calls and metagene plots, chaining fastp adapter trimming, STAR splice-aware alignment (NO deduplication for non-UMI MeRIP), deepTools replicate-concordance + IP-enrichment QC, PreSeq saturation curves, exomePeak2 (transcript-aware Poisson GLM) peak calling, optional MACS3 broad-peak cross-check, DRACH motif confirmation as a sanity check (NOT a per-peak filter), exomePeak2 differential calling via the four-BAM-vector interface (bam_ip + bam_input control; bam_treated_ip + bam_treated_input treatment), ChIPseeker annotation, and the canonical Guitar metagene with stop-codon enrichment as the biological QC anchor. Use when running a complete MeRIP analysis from raw reads, when chaining the constituent epitranscriptomics skills (merip-preprocessing -> m6a-peak-calling -> m6a-differential -> modification-visualization), or when wrapping the pipeline in Snakemake / Nextflow.
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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
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Design schemas and migrations, tune queries, or plan vector retrieval and database operations. Application API implementation uses oma-backend.
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Three.js (three, WebGL / WebGPU 3D グラフィクス) r186 リファレンス。 Scene, Group, PerspectiveCamera, OrthographicCamera, WebGLRenderer, WebGPURenderer, RenderPipeline、 BufferGeometry, BufferAttribute, StorageBufferAttribute, Mesh, InstancedMesh, SkinnedMesh、 MeshStandardMaterial, MeshPhysicalMaterial, ShaderMaterial, node-materials (TSL)、 DirectionalLight, SpotLight, PointLight, AmbientLight, PMREMGenerator、 GLTFLoader, FBXLoader, DRACOLoader, TextureLoader、 AnimationMixer, AnimationClip, AnimationAction, KeyframeTrack, Timer、 AudioListener, PositionalAudio、 Vector3, Matrix4, Quaternion, Euler, Color, Box3, Raycaster、 OrbitControls, TransformControls, WebXRManager。
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OpenAI API (developers.openai.com) の Agents SDK (Python / TypeScript)・Agents API (beta)。 Agent, Runner, handoffs, guardrails, tracing, SandboxAgent、 client.beta.agents の sessions / environments / vaults / plugins、 built-in tools（web search, file search, computer use, code interpreter, image generation）、 function tools, vector stores, MCP (Model Context Protocol) connectors, background mode, multi-agent orchestration。
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Supabase (オープンソース Firebase 代替・BaaS) リファレンス。 PostgreSQL ベース、Auth (Email / OAuth / Magic Link / Phone / SSO)、Storage、 Edge Functions (Deno)、Realtime (subscriptions / presence / broadcast)、Vector embeddings、 supabase-js、@supabase/server (withSupabase)、supabase CLI (supabase stack)、 Supabase MCP サーバー、RLS (Row Level Security)、migrations。 SQL Server / node-mssql は別スキル mssql。
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Identify tumor neoantigens from somatic variants with pVACtools (pVACseq/pVACfuse/pVACbind/pVACvector/pVACview) for personalized cancer vaccines and checkpoint biomarkers. Encodes the field's hard truth that binding prediction is the easy, near-solved part and single-digit-percent PPV lives downstream — so it centers clonality/CCF, HLA LOH (the silent invalidator), expression, proximal-variant phasing, agretopicity/foreignness quality, and the predicted->presented->immunogenic validation tiers. Use when nominating vaccine targets, ranking neoantigens, or building a tumor-to-candidate pipeline. Binding details in mhc-binding-prediction; ranking in immunogenicity-scoring.
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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
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Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, and applies the Patel et al 2024 *Nat Biotechnol* review's failure-mode framework to validate that normalization is correctly applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.
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Use when integrating LLMs, chat clients, embeddings, RAG pipelines, or AI agents into Spring Boot. Covers Spring AI ChatClient, prompt templates, embeddings, vector stores, and structured output. Use when user mentions Spring AI, LLM, ChatGPT, Claude, RAG, embeddings.
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Guide for building and refactoring a FastAPI + Prefect + PostgreSQL/pgvector analytics pipeline that extracts insights from chat data using LLM classification, embeddings, UMAP/HDBSCAN clustering, and narrative generation. Use this skill whenever working on this project's codebase — including adding features, refactoring, debugging, creating new endpoints, modifying pipeline stages, or reviewing architecture decisions. Also trigger when the user asks about project structure, stack decisions, async migration, or best practices for this specific system.
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Build search applications with vector, hybrid, and semantic search capabilities.
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Azure AI Search SDK for Python. Use for vector search, hybrid search, semantic ranking, indexing, and skillsets.
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Azure AI Search SDK for .NET (Azure.Search.Documents). Use for building search applications with full-text, vector, semantic, and hybrid search.
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Provide comprehensive techniques for testing REST, SOAP, and GraphQL APIs during bug bounty hunting and penetration testing engagements. Covers vulnerability discovery, authentication bypass, IDOR exploitation, and API-specific attack vectors.
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Audits GitHub Actions workflows for security vulnerabilities in AI agent integrations including Claude Code Action, Gemini CLI, OpenAI Codex, and GitHub AI Inference. Detects attack vectors where attacker-controlled input reaches. AI agents running in CI/CD pipelines.
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Build production-ready LLM applications, advanced RAG systems, and intelligent agents. Implements vector search, multimodal AI, agent orchestration, and enterprise AI integrations.
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Memory is the cornerstone of intelligent agents. Without it, every interaction starts from zero. This skill covers the architecture of agent memory: short-term (context window), long-term (vector stores), and the cognitive architectures that organize them.
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