1.2K skills · sorted by relevance
Detect sandbox evasion techniques in malware samples by analyzing timing checks, VM artifact queries, user interaction detection, and sleep inflation patterns from Cuckoo/AnyRun behavioral reports
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Enforce a configuration-driven design system when generating UI. Ensures consistent spacing, colors, typography, dark mode, interactions, and accessibility across all AI-generated components.
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Focused Signals scout for PostHog projects using session replay. Watches two promises the replay product makes: that sessions are actually being recorded (capture integrity — recording volume vanishing while site traffic doesn't), and that the friction evidence inside recordings gets seen (rage-click / dead-click clusters concentrating on a page or element, error-after-interaction cohorts, recurring replay vision themes nobody aggregates). Emits findings only when they clear the confidence bar; otherwise writes durable memory and closes out empty. Self-contained peer in the signals-scout-* fleet.
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Build genome-browser-style multi-track figures with pyGenomeTracks (config-driven), Gviz (R), and IGV batch screenshotting. Covers BigWig coverage tracks, BED/peak overlays, gene-model rendering, Hi-C matrix tracks, BedPE link arcs, spike-in-aware normalization, and the bamCoverage --normalizeUsing trap. Use when producing publication figures of genomic loci with stacked aligned tracks (coverage, peaks, genes, interactions) for ChIP-seq, ATAC-seq, RNA-seq, Hi-C, or generic locus visualization.
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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.
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Comprehensive ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiling for drug candidates. Integrates ADMET-AI predictions, SwissADME drug-likeness, PubChemTox experimental toxicity, ChEMBL clinical data, Lipinski rule-of-five, and CYP interaction data. Use for drug-likeness assessment, BBB penetration, bioavailability, hepatotoxicity prediction, ADME/PK profiling, or screening compound libraries before lab testing.
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Pharmacogenomics (PGx) research — drug-gene interactions (CPIC, PharmGKB), CPIC dosing guidelines, variant-drug-response associations, ethnic-allele-frequency considerations, and metabolizer-status scoring. Use for PGx-informed dosing recommendations, CYP/HLA pharmacogenomic allele interpretation, and clinically-actionable PGx report generation.
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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
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Comprehensive drug profiling — mechanism, primary/secondary targets, drug interactions, clinical-trial status, adverse events (FAERS), pharmacogenomics, and approval history. Use for full drug investigation reports, 'tell me about drug X' queries, and assembling drug profiles for clinicians, researchers, or regulatory work.
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Biological knowledge: query curated assertions and reference databases for genes, variants, pathways, regulation, cell types, reference atlases, perturbation-derived relationships, phenotypes, therapeutic targets, drugs, interactions, annotations, signatures, compounds, and predicted structures. Use for identifiers, marker sets, gene sets, associations, ontologies, database facts, and cross-database coverage.
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End-to-end molecular docking pipeline. Target preparation, pocket detection, protein-ligand docking (DiffDock/Vina), scoring, interaction analysis, and pose ranking.
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Publication-quality molecular visualization. 2D structure drawings (PNG/SVG), molecule grids with property annotations, scaffold highlighting, protein-ligand interaction diagrams, and interactive 3D views.
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Build or improve UI test coverage for visual regression, interactions, and accessibility. Use when the user asks for a test strategy, automated tests, testing setup, or fixes to flaky UI tests. A one-time browser inspection or visual review does not require a new test suite.
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Add moments of joy, personality, and surprise through success states, empty states, loading moments, hover details, and celebratory polish once the fundamentals already work. Use when the user wants delight, charm, personality, or memorable micro-interactions—not when the main need is baseline cleanup or stronger visual impact.
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Apple's approach to interface design and fluid, physical motion, translated for the web. Use when building or reviewing gesture-driven UI, spring animations, drag/swipe/sheet interactions, momentum and interruptible transitions, translucent materials and depth, typography (optical sizing, tracking, leading), reduced-motion, or the design foundations (feedback, spatial consistency, restraint) behind Apple-style interfaces.
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Define or review a visual system, DESIGN.md, or redesign direction. Use for typography, layout, color, motion, and interaction design decisions.
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Always use browser-harness for any web interaction: automation, scraping, testing, or site/app work.
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Windows アプリ開発 (DirectX / WinRT メディア) のグラフィックス・メディア API リファレンス。 Direct2D (ID2D1Factory, ID2D1DeviceContext, ID2D1Bitmap1, ID2D1Effect, D2D1 Effects, ID2D1PathGeometry), DirectWrite (IDWriteFactory, IDWriteTextLayout, DWriteCore), Direct3D 11/12 (D3D11CreateDevice, D3D11On12, DXGI SwapChain, HLSL, D3D12 PipelineState, D3D12 DRED), Microsoft.UI.Composition (Compositor, Visual, ExpressionAnimation, InteractionTracker, MicaController), カメラ・画面キャプチャ (MediaCapture, MediaFrameReader, GraphicsCaptureSession, Windows Studio Effects, OpenCV)、音声・動画再生 (MediaPlayer, MediaPlaybackSession, AudioGraph, MediaTranscoder, AdaptiveMediaSource, HLS, DASH, CastingDevicePicker, AudioPlaybackConnection)。
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Storybook (UI カタログ) リファレンス。story, CSF (Component Story Format), CSF Next (CSF Factories), args, argTypes, decorators, play function, interaction tests, autodocs, main.ts / preview.ts, アドオン (a11y, controls, viewport, themes), Vitest addon, test-runner, Storybook MCP server, components manifest, アドオン作成, upgrade / migration。
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UIKit iOS/iPadOS UI フレームワーク。 UIViewController, UINavigationController, UITabBarController, UISplitViewController, UIView, UILabel, UIButton, UITextField, UIScrollView, UIStackView, UITableView, UICollectionView, diffable data source, NSDiffableDataSourceSnapshot, UICollectionViewCompositionalLayout, Auto Layout, NSLayoutConstraint, NSLayoutAnchor, UILayoutGuide, intrinsicContentSize。 UIArrangementViewController, UISplitArrangement, UIOverlayArrangement, UIView.ReservedRegion, UIHingeInteraction, 縦軸バー, iPhone Duo adaptive layout (iOS 27.1+), scene-based life cycle 移行, UISceneAccessory。SwiftUI ArrangementView とは別 API。
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Bring the Unity Editor window to front. Use when Unity must be visible for visual checks or user-facing interaction.
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Design, implement, review, and audit Android Jetpack Compose UI/UX for phone interfaces. Use when a request concerns concrete Compose layout, components, interaction, accessibility, or visual behavior. Do not activate for framework or dependency presence alone; non-UI Android work is excluded.
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Audits Hibernate database interactions to prevent N+1 query problems in JVM apps.
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Analyze spatial cell-cell interactions, neighborhoods, and niches in IMC/MIBI data with squidpy and imcRtools, covering neighborhood-enrichment permutation nulls, the abundance-vs-density confound, inhomogeneous Ripley's K, cellular-neighborhood discovery, graph-construction (contact vs proximity), and edge effects. Use when testing whether cell types co-locate, choosing a spatial null, building a neighbor graph, discovering tissue niches, or deciding whether a spatial pattern is real or a density/segmentation artifact.
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