Results for “examples”

Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

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Use this skill when the user asks about Americans with Disabilities Act (ADA) accommodation for CDL drivers — interaction between ADA + FMCSA medical certification, when DOT-disqualifying conditions trigger ADA analysis, reasonable accommodation case examples, employer obligations, and how to handle a driver with a condition that may affect CDL status. Cite Title I ADA + 49 CFR 391.41.

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Creates comprehensive documentation for design systems - token tables, usage guidelines, component examples, and accessibility notes. Use after generating tokens to create developer-friendly docs.

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Generates production-ready design tokens from natural language descriptions. Outputs Tailwind configs, CSS custom properties, and DTCG W3C tokens from 24 trends + 31 AI-ready styles with 2800+ component examples.

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Long-running design anthropologist that builds comprehensive visual databases from 500-1000 real-world examples, extracting color palettes, typography patterns, layout systems, and interaction design across any domain (portfolios, e-commerce, SaaS, adult content, technical showcases). This skill should be used when users need exhaustive design research, pattern recognition across large example sets, or systematic visual analysis for competitive positioning.

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Own whether a multi-document product-architecture binder is internally consistent, complete against its stated customer/contingency/architecture coverage, and honest about which older product ambitions it has absorbed, superseded, deferred, contradicted, orphaned, or rejected. Use when running a binder Architect of Record pass, before an implementation chain cites a binder chapter as ready, when a proof-gate owner is missing, or when reconciling the binder against the older ambition corpus (website, plans, examples, ADRs). NOT for auditing a single Claude Skill bundle's structure or frontmatter (use skill-hygiene), rendering a single-PM accept/reject verdict on one finished deliverable (use port-daddy-user-surrogate-pm-review), or sequencing/stewarding a roadmap's sidequests once a gap or operator decision has been surfaced (use legible-roadmap-with-sidequests).

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Design bounded applications and workflows for an always-on AI agent with episodic memory. Covers product ideas, persistence-dependent workflows, and constructed examples that make delegation, interruption, evidence, and opt-out explicit. Activate on: "what can an always-on agent do", "persistent agent use cases", "agent applications", "proactive agent ideas", "what to build with episodic memory", "always-on agent product", "personal AI assistant ideas", "/always-on-agent-applications". NOT for: building the architecture (use always-on-agent-architecture), designing inputs (use always-on-agent-inputs), safety and privacy (use always-on-agent-safety).

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Architecture and systems design for agents that retain bounded state across sessions. Covers durable event history, owned state, derived memory, retrieval indexes, framework evaluation, recovery, deletion, and rebuild behavior. Uses constructed implementation examples and workload calibration rather than universal vendor, latency, similarity, retention, or cost claims. Activate on: "always-on agent", "persistent agent architecture", "episodic memory system", "agent memory design", "long-running agent", "stateful agent", "agent that remembers", "MemGPT architecture", "Letta deployment", "/always-on-agent-architecture". NOT for: choosing what data to feed the agent (use always-on-agent-inputs), brainstorming applications (use always-on-agent-applications), safety and privacy concerns (use always-on-agent-safety), general agentic patterns (use agentic-patterns).

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Manages shadcn components and projects — adding, searching, fixing, debugging, styling, and composing UI. Provides project context, component docs, and usage examples. Applies when working with shadcn/ui, component registries, presets, --preset codes, or any project with a components.json file. Also triggers for "shadcn init", "create an app with --preset", or "switch to --preset".

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PSR-1 and PSR-12 coding standards knowledge base for PHP 8.5 projects. Provides quick reference for basic coding standard and extended coding style with detection patterns, examples, and antipattern identification. Use for code style audits and compliance reviews.

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SOLID principles knowledge base for PHP 8.5 projects. Provides quick reference for SRP, OCP, LSP, ISP, DIP with detection patterns, PHP examples, and antipattern identification. Use for architecture audits and code quality reviews.

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Generates README.md files for PHP projects. Creates structured documentation with badges, installation, usage, and examples.

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Generates API documentation for PHP projects. Creates endpoint documentation with parameters, responses, and examples.

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Use when explaining concepts at different expertise levels, moving between abstract principles and concrete implementation, identifying edge cases by testing ideas against scenarios, designing layered documentation, decomposing complex problems into actionable steps, or bridging strategy-execution gaps. Invoke when user mentions abstraction levels, making concepts concrete, or explaining at different depths.

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将抽象的Acceptance Criteria（Given-When-Then）转换为具体的数值示例和真实对话，让AC对PM/客户/测试人员更易懂。适合在AC编写完成后、准备测试或向客户展示时使用，当AC格式正确但过于抽象时。帮助不熟悉BDD的PM/BA/测试人员理解测试场景，让AC从抽象规则变成可直接用于手动测试的具体步骤。

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Create documentation with gaming-specific examples, retro styling, and 8-bit terminology. Apply when documenting gaming blocks, RPG components, or retro-styled UI elements.

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Neural search via Exa MCP for web, code, and company research. Use when the user needs web search, code examples, company intel, people lookup, or AI-powered deep research with Exa's neural search engine.

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Write articles, guides, blog posts, tutorials, newsletter issues, and other long-form content in a distinctive voice derived from supplied examples or brand guidance. Use when the user wants polished written content longer than a paragraph, especially when voice consistency, structure, and credibility matter.

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Write articles, guides, blog posts, tutorials, newsletter issues, and other long-form content in a distinctive voice derived from supplied examples or brand guidance. Use when the user wants polished written content longer than a paragraph, especially when voice consistency, structure, and credibility matter.

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Generate comprehensive, developer-friendly API documentation from code, including endpoints, parameters, examples, and best practices

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Use this skill when building or debugging URL-backed state with nuxt-ui-tools as a package consumer. Covers codecs, useQueryState, useQueryStates, dynamicQueryState, grouped state, dynamic keys, and practical query-string examples.

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Use this skill when adding, restructuring, or validating the nuxt-ui-tools playground examples, shell, navigation, or route-level composition demos.

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Use this skill when building or debugging table usage with nuxt-ui-tools as a package consumer. Covers defineTableSchema, useTable, DataList, granular composition, columns, filters, sorting, offset or cursor loading, layouts, summary rows on phones, first-use empty states, actions, selection, accessible row names, context, and URL state with concrete examples.

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Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, artifacts, posters, or applications (examples include websites, landing pages, dashboards, React components, HTML/CSS layouts, or when styling/beautifying any web UI). Generates creative, polished code and UI design that avoids generic AI aesthetics.

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