266 skills · sorted by relevance
Collect new feedback from configured Slack and GitHub Issues sources, acknowledge receipt, analyze recordings, and verify claimed fixes against the default branch. Combine unresolved items into a rolling plan ready for the lfg workflow.
Explain how something works, why it took its current form, or what happened during a period of work. Use supporting evidence, distinguish documented reasons from inference, and adapt the answer or document to its readers.
Create or update STRATEGY.md through guided questions about a product’s purpose, users, success metrics, and investment areas. Capture a shared basis for product decisions, with draft review and focused updates to existing documents.
Analyze rejected plans and reviewer feedback to identify recurring concerns, changing expectations, and concrete prompt improvements. Produce an HTML dashboard from Plannotator archives, or use Claude Code plan rejection reasons when those archives are unavailable.
Helps an agent take over an existing role after a planned handover. It guides checks of inherited records, identity, authority, and recurring duties, while explaining how to recover the predecessor’s reasoning and preserve lessons for the next agent.
Turn broad life sciences questions into focused research plans. Resolve names and identifiers for genes, diseases, or compounds, select relevant research skills, and combine evidence into a concise answer that explains uncertainty and useful follow-up analyses.
Refactor React components that have too many true-or-false settings into reusable, flexible parts. This skill guides component composition, shared state, and API design, with examples and separate guidance for React 19 features.
Explore DeFi products, blockchain-based financial services, aggregated by OKX. Check yields, historical data, and existing positions across supported chains, then handle deposits, withdrawals, or reward claims through the onchainos CLI.
Run a research task through five ordered stages: brainstorming, planning, implementation, review, and documentation. The workflow checks that brainstorming and planning files exist before proceeding, then reviews and documents what the implementation stage produced.
Find scientific papers in PubMed by turning a research question into targeted search terms and synonyms. Collect titles, authors, abstracts, and identifiers into a structured paper list ready for relevance evaluation.
React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.
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Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.
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Query ChEMBL bioactive molecules and drug discovery data. Search compounds by structure/properties, retrieve bioactivity data (IC50, Ki), find inhibitors, perform SAR studies, for medicinal chemistry.
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Personalized coding tutorials that build on your existing knowledge and use your actual codebase for examples. Creates a persistent learning trail that compounds over time using the power of AI, spaced repetition and quizes.
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Search PubMed for scientific literature, including published clinical trials. Fetch abstracts and full text. Link published research to biological databases (gene, protein, nucleotide, PubChem) to discover associations between papers and specific compounds or genes. Verify medical spelling, match raw citations, and cache result sets for bulk processing. Interfaces NCBI E-utilities and PMC BioC APIs.
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Query the ChEMBL database for bioactive molecules, drug targets, bioactivity data, approved drugs, and chemical structures. Use when the user asks about compounds, targets, IC50/Ki values, drug mechanisms, or structure searches.
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Enumerates chemical libraries through reaction SMARTS transformations using RDKit. Generates virtual compound libraries from building blocks using defined chemical reactions with product validation. Use when creating combinatorial libraries or enumerating products from synthetic routes.
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Metabolite identification from m/z and retention time. Covers database matching, MS/MS spectral matching, and confidence level assignment. Use when assigning compound identities to detected features in untargeted metabolomics.
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Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted safety.
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Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
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Manages Amazon DocumentDB end-to-end — serverless-on-8.0 cluster setup, TLS/VPC/driver config, flexible-schema and vector-search data modeling, MongoDB compatibility assessment, DMS-based migration, slow-query diagnosis, major version upgrades (4.0->5.0->8.0), Well-Architected reviews (41-check wa_review.py), cost estimation, and security hardening. Retrieve for every DocumentDB question and when the user asks to set up or migrate MongoDB to AWS — DocumentDB is AWS's MongoDB-compatible managed database. Triggers: JSON document store, document database, MongoDB on AWS, Nested fields, Lambda cannot connect, TLS handshake, VPC port 27017, IAM auth, Secrets Manager, encryption at rest, $graphLookup, flexible schema, COLLSCAN, compound index, DMS migration, CDC cutover, $vectorSearch, RAG, Global Clusters, DR replication, cost sizing, audit, health check, production-readiness.
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Diagnose and fix retention problems using behavior design (B=MAP). Use when the user mentions "users sign up but dont stick around", "activation rate", "onboarding friction", "retention metrics", "why users dont complete", "churn analysis", or "aha moment". Also trigger when analyzing cohort retention curves, designing activation milestones, reducing time-to-value for new users, or investigating why users quit after their first session. Covers the Ability Chain, prompt design, and tiny behaviors that compound. For habit loops and variable rewards, see hooked-ux. For intrinsic motivation, see drive-motivation.
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Finds the single constraint currently limiting a business's growth and the highest-leverage moves against it, rather than producing a list of everything that could be improved. Use this when growth has stalled or slowed, when deciding where to spend limited time or budget, when revenue rises but profit does not, when prioritizing growth initiatives, or when a business feels busy without compounding.
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Filter compound libraries based on Lipinski's Rule of Five for drug-likeness.
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