Results for “estimation”

Performs epidemiological analyses including disease modeling (SIR/SEIR), outbreak investigation, risk factor identification, incidence/prevalence estimation, and causal inference from observational data; trigger when users discuss disease spread, public health data, or populat...

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Generates complete two-sample Mendelian randomization research designs from a user-provided outcome, exposure or exposure family, and robustness direction. Use when a study centers on summary-statistics causal inference with instrument selection, harmonization, IVW-primary estimation, complementary estimators, sensitivity analyses, optional multivariable upgrades, and conservative evidence interpretation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Generates complete tumor immune-infiltration-guided bulk-transcriptome diagnostic biomarker and machine-learning research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, immune infiltration estimation, immune-linked module discovery, consensus feature selection, diagnostic modeling, nomogram construction, clinical association, and optional prognostic extension or validation. Covers five study patterns (immune-cell-first diagnostic workflow, immune-module-to-biomarker workflow, consensus-ML biomarker workflow, diagnostic-plus-prognostic hybrid workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, reference literature pack, and self-critical risk review.

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Plans sample size estimation logic, power assumptions, feasibility checks, and fallback enrollment strategies for clinical and translational study protocols.

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Designs studies for predicting treatment response or resistance in biomedical and clinical research. Always use this skill when the user needs a treatment-response or resistance prediction study blueprint rather than a prognostic biomarker protocol, diagnostic test design, causal treatment-effect estimation, or a completed manuscript. Focus on responder definition, treatment context, baseline comparability, feature integration strategy, model development logic, validation architecture, and interpretation boundaries. Do not invent response rates, cohort size, assay readiness, regimen uniformity, literature support, or validation access.

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Use when estimating immune infiltration from bulk RNA-seq expression matrices with ssGSEA/GSVA, comparing case versus control groups, and generating downstream immune-score visualizations. NOT for single-cell RNA-seq, absolute cell proportion estimation, or clinical decision making.

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Design effective excitation signals (step tests) for system identification and parameter estimation in control systems.

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Use scipy.optimize.curve_fit for nonlinear least squares parameter estimation from experimental data.

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Estimate camera motion with optical flow + affine/homography, allow multi-label per frame.

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Diagnostic guide for RL-based post-training of language models (GRPO, PPO, REINFORCE, DPO). Use proactively when debugging a training pipeline that shows no improvement, loss anomalies, reward stagnation, NaN gradients, or other unexpected behavior during reinforcement learning fine-tuning. Work through all pipeline stages — reward, advantages, log-probs, loss, generation/decoding — before concluding the diagnosis is complete; stopping after one or two fixes is a common failure mode. Covers log-probability math, advantage estimation, numerical stability, reward processing, and generation/decoding pipeline issues.

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Reference for the GRPO (Group Relative Policy Optimization) algorithm. Use when implementing, debugging, or verifying a GRPO training pipeline — covers the mathematical formulation (group-relative advantages, clipped surrogate loss, KL penalty), the training loop (generate → score → advantage → loss), log-probability computation, advantage estimation, and relationship to PPO/REINFORCE.

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An overview of the core model API of SeisBench, a Python framework for training and applying machine learning algorithms to seismic data. It is useful for annotating waveforms using pretrained SOTA ML models, for tasks like phase picking, earthquake detection, waveform denoising and depth estimation. For any waveform, you can manipulate it into an obspy stream object and it will work seamlessly with seisbench models.

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Automated Big-O complexity analysis of code and algorithms. Performs static analysis of loop structures, recursive call trees, space complexity estimation, and amortized analysis with detailed derivation documents.

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Forecast Azure spend and price planned resources or workloads. WHEN: "forecast Azure spending", "project next month cost", "compare forecast to my planning target", "how much will Azure cost", "estimate VM cost", "compare storage tiers", "compare Azure regions", "retail price", "EA rate card", "negotiated pricesheet". DO NOT USE FOR: configured budget health or alerts, bill analysis, cost spikes, rightsizing, or commitments.

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Database specialist for SQL, NoSQL, and vector database modeling, schema design, normalization, indexing, transactions, integrity, concurrency control, backup, capacity planning, data standards, anti-pattern review, and compliance-aware database design. Use for database, schema, ERD, table design, document model, vector index design, RAG retrieval architecture, migration, query tuning, glossary, capacity estimation, backup strategy, database anti-pattern remediation work, and ISO 27001, ISO 27002, or ISO 22301-aware database recommendations.

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Use when planning or reporting the analysis for an American Educational Research Journal (AERJ) manuscript — multilevel/HLM and growth models, IRT/measurement, quasi-experimental estimation, or qualitative coding and thematic analysis. Analysis must meet the AERA reporting standards (warrant + transparency). Strengthens analysis reporting; it does not run models for you.

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Use when assembling the proof appendix and any code/data deposit for an American Economic Journal: Microeconomics (AEJ: Micro) manuscript under the AEA Data and Code Availability Policy. Covers proof appendices for pure theory plus numerical/structural/experimental code; it does not run your estimation.

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Use when the quantitative model is the bottleneck for an American Economic Journal: Macroeconomics (AEJ: Macro) manuscript — DSGE, New Keynesian, heterogeneous-agent (HANK / Aiyagari-Bewley), or structural estimation — and calibration, parameter identification, solution accuracy, or counterfactual validity need discipline. For empirical shock identification see aejmac-identification.

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Use when building or revising exhibits for an AEJ: Economic Policy manuscript so they meet AEA house style and carry the policy message — no significance asterisks, a self-contained headline exhibit, and figures that show the policy effect with uncertainty. Designs exhibits; it does not run the estimation or write the surrounding prose.

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Use when an American Economic Journal: Applied Economics (AEJ: Applied) manuscript needs a model to interpret, discipline, or structure its empirical estimates — not to lead the paper. Calibrates how much theory belongs in an empirical-first journal and where it goes; it does not design the identification (aeja-identification) or build a standalone structural estimation.

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Use when deciding whether a project fits AEJ: Economic Policy rather than J. Public Economics, AEJ: Applied, or AER, and when sharpening the policy question and its welfare stake for an AEJ: Economic Policy manuscript. Frames fit and the policy-question-first contribution; it does not design the identification or run estimation.

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Use when an AEJ: Economic Policy manuscript needs a framework that maps reduced-form estimates into a welfare, cost-benefit, or distributional policy object — sufficient statistics, MVPF, optimal-policy, or a small applied model. Builds the estimate-to-welfare bridge and states its assumptions; it does not run the empirical estimation or write the prose.

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Use when an AEJ: Economic Policy decision letter (R&R or reject-and-resubmit) has arrived and a response-letter strategy and revision plan are needed. Structures the response to referees and editor with policy-relevance front and center; it does not run new estimation or redesign identification from scratch.

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Use when executing and reporting the analysis for an Administrative Science Quarterly (ASQ) manuscript — qualitative coding and data-to-theory construction, or quantitative estimation and robustness. Makes the evidence-to-theory link transparent; it does not design the study (see asq-methods).

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