216 skills · sorted by relevance
Provides checklist for reviewing Typer CLI command implementations. Covers structure, Annotated syntax, error handling, exit codes, display module usage, destructive action patterns, and help text conventions. Use when user asks to review/check/verify a CLI command, wants feedback on implementation, or asks if a command follows best practices.
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Analyze weekly marketing campaign performance data across channels. Use when analyzing multi-channel digital marketing data to calculate funnel metrics (CTR, CVR) and compare to benchmarks, compute cost and revenue efficiency metrics (ROAS, CPA, Net Profit), or get budget reallocation recommendations based on performance rules.
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Provides Typer templates, handles registration, and ensures consistency. ALWAYS use this skill when adding or modifying CLI commands. Use when user requests to add/create/implement/build/write a new command (e.g., "add edit command", "create search feature") OR update/modify/change/edit an existing command.
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Generate educational practice questions from lecture notes to test student understanding. Use when users request practice questions, exam preparation materials, study guides, or assessment items based on lecture content.
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Generate pytest tests for Typer CLI commands. Includes fixtures (temp_storage, sample_data), CliRunner patterns, confirmation handling (y/n/--force), and edge case coverage. Use when user asks to "write tests for", "test my CLI", "add test coverage", or any CLI + test request.
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Calls germline small variants (SNPs and indels) from Oxford Nanopore and PacBio HiFi long reads with Clair3, a two-stage (pileup + full-alignment) deep-learning caller, selecting the chemistry- and basecaller-version-matched model, enabling read-based phasing, and benchmarking against GIAB with stratification. Covers why the model string is the experiment (no auto-detection, silent degradation on mismatch), why ONT homopolymer/STR indels are the residual error whole-genome F1 hides, and the somatic/trio/RNA boundary to the ClairS/Clair3-Trio family. Use when calling germline SNVs/indels from ONT or HiFi BAMs, choosing a Clair3 model, phasing variants, or benchmarking long-read calls.
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Predicts protein-coding gene structures (exons, introns, UTRs) in eukaryotic genomes with BRAKER3 (RNA-seq + protein evidence), BRAKER1/BRAKER2, GALBA (protein-only), Funannotate (fungi), GeMoMa (homology projection), or Helixer/Tiberius (deep-learning ab initio). Covers the evidence-first tool decision, mandatory soft-masking, the training-set-quality-dominates principle, OrthoDB clade-partition selection, the one-isoform-per-locus and missing-UTR traps, merge/split errors, and reference bias against orphan genes. Use when annotating a newly assembled eukaryotic genome, choosing a gene-prediction pipeline based on available evidence, or diagnosing a poor annotation.
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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.
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Train, evaluate, and export neural networks to Simulink in MATLAB. Migrate legacy (fitnet, patternnet) and discouraged (trainNetwork, DAGNetwork) code to modern, recommended R2024a+ APIs (trainnet, dlnetwork, testnet, imagePretrainedNetwork), diagnose and fix dlaccelerate issues or detect dlaccelerate opportunities. Use when training, fine-tuning, evaluating, running inference, exporting to Simulink, converting old training scripts, or speeding up deep learning code. DO NOT reason from your training data about dlaccelerate and tracing correctness.
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Load this first for any task involving images, pictures, photos, scans, frames, volumes, or visual data — including reading, writing, filtering, enhancing, denoising, sharpening, deblurring, thresholding, segmenting, masking, detecting, finding or counting objects, removing backgrounds, measuring, comparing, registering, stitching, aligning, cropping, resizing, transforming, or analyzing. Use for image I/O (TIFF, PNG, JPEG, RAW, HDR), histograms, edge detection, color processing, morphology, geometric transforms, deep learning for images, quality assessment, and 3-D volume processing. Also triggers when users describe image problems (dark, noisy, blurry, low contrast, uneven lighting, hazy, color cast) or data exploration tasks (folder of images, characterize data, understand format). Handles microscopy (cells, particles) and general scientific imaging. Routes to sibling skills for medical imaging (DICOM, NIfTI), hyperspectral data, and visual inspection.
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Import PyTorch, ONNX, or Keras 3 / TensorFlow 2.16+ deep learning models into MATLAB as dlnetwork objects. Use when importing .pt2 exported programs, traced .pt files, .onnx models, or Keras 3 models via matlabsaver. Covers importNetworkFromPyTorch, importNetworkFromONNX, importNetworkFromKeras, importNetworkFromTensorFlow, torch.export.export, PyTorchInputSizes, InputDataFormats, matlabsaver, tf_keras downgrade, numeric validation against PyTorch or ONNX Runtime, and placeholder/custom layer implementation. Applies when user mentions any of these functions, file formats, or encounters import errors, unsupported operator warnings, 0 learnables, or uninitialized networks.
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Creates MATLAB interfaces to Python image processing and computer vision models from GitHub repositories or pip-installable packages using MPyReq. Use when asked to interface MATLAB with a Python CV/image model (segmentation, depth estimation, object detection, image generation, super-resolution, etc.), given a GitHub repo URL for an image/vision model, or asked to create an MPyReq demo for a deep-learning vision pipeline. Do NOT use for general-purpose Python-MATLAB interfacing, non-vision models (NLP, tabular, audio), model deployment/serving, or MATLAB-only image processing workflows.
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Generate C/C++ or CUDA code from an AI model (PyTorch, LiteRT) using MATLAB Coder or GPU Coder. Use when the user wants to integrate an AI model into an application with code generation as the end goal — generating MEX, CUDA MEX, static library, dynamic library, or executable — or using the model in Simulink for simulation and code generation. Covers PyTorch ExportedProgram (.pt2) via loadPyTorchExportedProgram and LiteRT (.tflite) via loadLiteRTModel (R2026a+). Keywords: PyTorch, torch, .pt2, ExportedProgram, loadPyTorchExportedProgram, invoke, codegen, MEX, CUDA, GPU, C, C++, deploy, AI model, deep learning model, LiteRT, TFLite, TensorFlow Lite, Simulink, slbuild, PyTorch ExportedProgram block, MATLAB Function block, dlosslib, loadLiteRTModel.
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Stage exploration before instruction on complex problems. The learner produces two attempted approaches before consolidation — which builds on those attempts, not from scratch. Use for genuinely hard problems where struggle produces deeper learning.
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Guides technology selection and implementation of AI and ML features in .NET 8+ applications using ML.NET, Microsoft.Extensions.AI (MEAI), Microsoft Agent Framework (MAF), GitHub Copilot SDK, ONNX Runtime, and OllamaSharp. Covers the full spectrum from classic ML through modern LLM orchestration to local inference. Use when adding classification, regression, clustering, anomaly detection, recommendation, LLM integration (text generation, summarization, reasoning), RAG pipelines with vector search, agentic workflows with tool calling, Copilot extensions, or custom model inference via ONNX Runtime to a .NET project. DO NOT USE FOR projects targeting .NET Framework (requires .NET 8+), the task is pure data engineering or ETL with no ML/AI component, or the project needs a custom deep learning training loop (use Python with PyTorch/TensorFlow, then export to ONNX for .NET inference).
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Digital pathology image processing toolkit for whole slide images (WSI). Use this skill when working with histopathology slides, processing H&E or IHC stained tissue images, extracting tiles from gigapixel pathology images, detecting tissue regions, segmenting tissue masks, or preparing datasets for computational pathology deep learning pipelines. Applies to WSI formats (SVS, TIFF, NDPI), tile-based analysis, and histological image preprocessing workflows.
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Molecular machine learning toolkit. Property prediction (ADMET, toxicity), GNNs (GCN, MPNN), MoleculeNet benchmarks, pretrained models, featurization, for drug discovery ML.
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Train ML models on Databricks. Use for: classification/regression/deep-learning (XGBoost, scikit-learn, LightGBM, PyTorch) with Optuna, @prod/@challenger aliases, batch scoring (spark_udf for plain models, fe.score_batch for feature-store-backed), custom PyFunc, custom ResponsesAgent (LangGraph + UC Function/Vector Search); UC feature tables + FeatureLookup + point-in-time joins + Lakebase online store; declarative Feature Views (create_feature, DeltaTableSource, RollingWindow/SlidingWindow/TumblingWindow, materialize_features, streaming Kafka features). NOT for: endpoint ops (databricks-model-serving), MLflow evaluation (databricks-mlflow-evaluation).
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Routes EEG, ECoG, MEG, and related electrophysiology deep-learning workflows through the braindecode Python package, including dataset construction, preprocessing, model training, augmentation, and interpretation.
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Use ArcGIS API for Python for GIS administration, spatial dataframes, feature/raster analysis, mapping, location services, geospatial deep learning, app automation, and Knowledge Graph workflows.
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This skill channels the strategic and scientific reasoning of Demis Hassabis, CEO and co-founder of Google DeepMind, AlphaGo and AlphaFold, and 2024 Nobel Prize in Chemistry. Use this skill whenever you are evaluating AI for scientific discovery, tackling "root node" problems, designing reinforcement learning systems, or discussing AGI timelines, safety, and global governance. Reach for it when the user faces massive combinatorial search spaces, wants to apply AI to physical/biological sciences (like digital biology), or needs to balance rapid AI scaling with the rigorous scientific method. Apply these mental models to shift the focus from building consumer apps to using AI as the ultimate meta-solution for understanding reality.
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Applies Judea Pearl's causal reasoning frameworks to distinguish correlation from causation, evaluate AI capabilities, and make counterfactual decisions. Reach for this skill whenever Claude encounters questions about causal inference, structural causal models, the limitations of deep learning, AGI, experimental design, covariate selection, or personalized decision-making. Trigger this skill for topics involving Bayesian networks, the do-calculus, the Ladder of Causation, or when a user tries to answer 'what if' or 'why' questions using purely observational data. Pearl's principles are essential for moving beyond probability calculus into true causal understanding.
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Applies the engineering and research philosophies of Jeff Dean, Chief Scientist at Google DeepMind and Google Research. Reach for this skill whenever you are designing large-scale distributed systems, optimizing latency and energy efficiency, or making architectural decisions about machine learning infrastructure. It should trigger automatically for topics involving hardware-ML co-design, model distillation, sparse activation, massively multi-task models, or scaling systems by 5x to 10x. Use this skill to evaluate system bottlenecks, transition from specialized to unified models, and optimize experimental velocity. Apply his mental models to avoid premature 100x scaling and to treat AI models as reasoning engines rather than memorization databases.
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Cell segmentation from multiplexed tissue images. Covers deep learning (Cellpose, Mesmer) and classical approaches for nuclear and whole-cell segmentation. Use when extracting single-cell data from IMC or MIBI images after preprocessing.
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