497 skills · sorted by relevance
Use when performing sample-level dimensionality reduction and visualization on abundance or OTU-style matrices with a companion group file, generating UMAP and/or t-SNE coordinates and plots for group separation assessment. NOT for: differential expression testing, single-cell workflows requiring dedicated embeddings pipelines, or analyses without a sample grouping file.
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Use when performing correlation analysis between two variables including Pearson and Spearman correlation methods. Supports command-line parameter input, automatic data format detection, parameter validation, result directory creation, and CSV or TXT format result export.
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Use when performing time-dependent ROC curve analysis for survival data with follow-up time, event status, and a numeric marker. Supports CSV/TXT/TSV/Excel input, `risk_score` as the default marker unless `--marker_col` is provided, parameter validation, standardized output directories, AUC table export, ROC point export, and PDF figure generation.
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Use when performing GO and KEGG enrichment on a gene list from bulk RNA-seq or microarray studies, then generating a combined GO/KEGG dot chart. NOT for single-cell RNA-seq, methylation data, or non-expression data.
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World-class data science skill for statistical modeling, experimentation, causal inference, and advanced analytics. Expertise in Python (NumPy, Pandas, Scikit-learn), R, SQL, statistical methods, A/B testing, time series, and business intelligence. Includes experiment design, feature engineering, model evaluation, and stakeholder communication. Use when designing experiments, building predictive models, performing causal analysis, or driving data-driven decisions.
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Comprehensive security engineering skill for application security, penetration testing, security architecture, and compliance auditing. Includes security assessment tools, threat modeling, crypto implementation, and security automation. Use when designing security architecture, conducting penetration tests, implementing cryptography, or performing security audits.
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Matched filtering techniques for gravitational wave detection. Use when searching for signals in detector data using template waveforms, including both time-domain and frequency-domain approaches. Works with PyCBC for generating templates and performing matched filtering.
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Analyze geospatial data using geopandas with proper coordinate projections. Use when calculating distances between geographic features, performing spatial filtering, or working with plate boundaries and earthquake data.
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Use this skill when working with symbolic mathematics in Python. This skill should be used for symbolic computation tasks including solving equations algebraically, performing calculus operations (derivatives, integrals, limits), manipulating algebraic expressions, working with matrices symbolically, physics calculations, number theory problems, geometry computations, and generating executable code from mathematical expressions. Apply this skill when the user needs exact symbolic results rather than numerical approximations, or when working with mathematical formulas that contain variables and parameters.
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DC power flow analysis for power systems. Use when computing power flows using DC approximation, building susceptance matrices, calculating line flows and loading percentages, or performing sensitivity analysis on transmission networks.
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Extract locational marginal prices (LMPs) from DC-OPF solutions using dual values. Use when computing nodal electricity prices, reserve clearing prices, or performing price impact analysis.
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Master memory forensics techniques including memory acquisition, process analysis, and artifact extraction using Volatility and related tools. Use when analyzing memory dumps, investigating incidents, or performing malware analysis from RAM captures.
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Execute database migrations across ORMs and platforms with zero-downtime strategies, data transformation, and rollback procedures. Use when migrating databases, changing schemas, performing data transformations, or implementing zero-downtime deployment strategies.
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Master binary analysis patterns including disassembly, decompilation, control flow analysis, and code pattern recognition. Use when analyzing executables, understanding compiled code, or performing static analysis on binaries.
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Publish finished creatives as live Meta (Facebook/Instagram) ads via the Meta Marketing API, plus research and ad-copy support. Uploads an image or video, builds a multi-variant TEXT_LIQUIDITY creative, and creates a PAUSED ad in an existing ad set. Also pulls top-performing ads (ranked by ROAS) and competitor ads from the Ad Library to inform copy. Use when the user asks to deploy / publish / launch a creative as a Meta or Facebook ad, build a Meta ad, push a video or image into an ad set, pull their top ads, or research competitor ads. Not for generating creative (use the image/video skills) and not for writing AdTable/Airtable rows (use adtable-light).
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Write the band agreement before the money or the breakup arrives — who owns the songs, how money splits (writing vs performing distinguished), who owns the name, what happens when someone quits, and the decision rules for offers — decided while everyone still shares a van. Use when a band asks 'how should we split money', 'who owns our songs', 'our drummer quit, what happens', or is about to record/release/sign anything. Produces a plain-language band agreement and the meeting script to agree it. Not legal advice — it's the conversation that makes the lawyer cheap later.
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Help users design and maintain a high-performing culture by balancing radical transparency, psychological safety, and a relentless focus on customer delight.
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Help users design high-performing product and engineering organizations by choosing the right reporting models, team sizes, and cross-functional partnerships. It focuses on reducing friction and maximizing ownership through structural clarity.
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Help users identify why a team is struggling and implement a structured recovery plan by addressing leadership gaps, individual performance, and structural misalignments.
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AI sales coach composite. Analyzes all available sales data — email campaigns, call recordings/transcripts, reply patterns, pipeline outcomes — to identify what the user does well, where they struggle, and how to improve. Finds patterns in top-performing emails, winning call techniques, successful objection handles, and deal progression. Produces personalized coaching recommendations based on their specific product, market, and selling style. Tool-agnostic.
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Pull real SEO metrics for any domain using Apify scrapers for Semrush and Ahrefs data. Gets domain authority, organic traffic estimates, keyword rankings, backlink profiles, top performing pages, and auto-discovers competitors from keyword overlap. No Semrush/Ahrefs subscription needed — uses Apify actors that scrape public pages.
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Configures Simulink simulations non-destructively using SimulationInput objects — parameter overrides without modifying the model, batch sweeps via parsim, custom input signals via Dataset, and simulation data retrieval via logsout. Use when running sim()/parsim() with setVariable, setBlockParameter, setExternalInput, or when performing parameter sweeps and multi-run analysis. Not needed for one-shot simulations without configuration.
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Identifies non-coding RNAs (tRNA, rRNA, snoRNA, snRNA, riboswitches, sRNAs) using Infernal covariance-model search against Rfam, tRNAscan-SE 2.0 for tRNA, barrnap for rRNA, and ARAGORN for tmRNA, plus the small-RNA-seq boundary for miRNA and the transcript-assembly boundary for lncRNA. Covers the structure-conserved-not-sequence-conserved principle (why BLAST fails), GA-threshold and clan-competition correctness, tRNAscan-SE domain modes and pseudogene flags, rDNA copy-number collapse, and why homology annotation is a recall floor. Use when performing genome-wide ncRNA annotation, choosing the right tool for an RNA class, or interpreting ncRNA counts.
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Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.
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