Results for “spl”

Validates predictive models on omics and biomedical data with nested cross-validation, group/batch/temporal-aware splits, the full data-leakage taxonomy, probability calibration, decision-curve net benefit, optimism correction, sample-size planning, and TRIPOD+AI reporting. Use when estimating model performance honestly, choosing a CV scheme, detecting leakage, or judging whether reported discrimination means the model is actually useful. For feature selection itself see machine-learning/biomarker-discovery; for confirmatory-trial inference see clinical-biostatistics/trial-reporting.

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Orchestrates an end-to-end MeRIP-seq / m6A-seq analysis from raw FASTQ to differential m6A peak calls and metagene plots, chaining fastp adapter trimming, STAR splice-aware alignment (NO deduplication for non-UMI MeRIP), deepTools replicate-concordance + IP-enrichment QC, PreSeq saturation curves, exomePeak2 (transcript-aware Poisson GLM) peak calling, optional MACS3 broad-peak cross-check, DRACH motif confirmation as a sanity check (NOT a per-peak filter), exomePeak2 differential calling via the four-BAM-vector interface (bam_ip + bam_input control; bam_treated_ip + bam_treated_input treatment), ChIPseeker annotation, and the canonical Guitar metagene with stop-codon enrichment as the biological QC anchor. Use when running a complete MeRIP analysis from raw reads, when chaining the constituent epitranscriptomics skills (merip-preprocessing -> m6a-peak-calling -> m6a-differential -> modification-visualization), or when wrapping the pipeline in Snakemake / Nextflow.

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Therapeutics Data Commons. AI-ready drug discovery datasets (ADME, toxicity, DTI), benchmarks, scaffold splits, molecular oracles, for therapeutic ML and pharmacological prediction.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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AdwHeaderBar layout rules: button placement, flat/icon-only buttons, tooltips, title widgets, split buttons. Use when designing or fixing a GNOME app's header bar.

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Rules for the VenTu data layer — scripts/, public/data/, scores, buoys (IH/WMO), Open-Meteo, IPMA, Ecowitt, news, Dawn Patrol. Use whenever touching data scripts, generated JSON, scoring, staleness display, or any data source.

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Design A/B tests with hypotheses, variants, sample sizes, and analysis plans. TRIGGERS - Use when user wants to run A/B tests, split tests, or experiment with variations.

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Upscale a low-resolution image using AI super-resolution for print or high-DPI display.

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Creates and edits CARLA Leaderboard route files — placing waypoints and scenario trigger points interactively from the spectator camera (route_creator, scenario_creator), visualising an existing route in the simulator (route_displayer), summarising it as a table (route_summarizer), capturing the current weather in route format (weather_creator), sorting scenarios by route position (scenario_orderer) and converting 1.0-format routes to 2.x (route_bridge). Use when the user asks to "make a new route", "add a scenario to a route", "visualise/debug a route", "see what's in this route file", or "convert old leaderboard routes".

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Transcribing, displaying and animating captions

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Refactor a whole documentation page in this repository without losing source-verified behavior facts. Use for page rewrites, splits, reorganizations, or substantial shortening of README sections, docs pages, or instruction files. Do not use for ordinary documentation authoring, targeted corrections, or documentation review; use technical-documentation instead.

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Write, review, or audit this repository's technical documentation, including README.md, CONTRIBUTING.md, root and scoped AGENTS.md files, docs pages, and documentation drift. Use for source-backed documentation authoring, behavior verification, and cross-surface consistency. Do not use for code review, deslop diff cleanup, or whole-page rewrites, splits, or reorganizations handled by docs-refactor.

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Windows アプリ開発 (WinUI 3 / XAML) の UI 基盤リファレンス。 Grid, StackPanel, Canvas, RelativePanel, SplitView, ScrollViewer、x:Bind, x:Name, x:Class, StaticResource, ThemeResource、添付プロパティ, 依存関係プロパティ、Style, ControlTemplate, DataTemplate, VisualStateManager, ResourceDictionary、Acrylic, Mica, SystemBackdrop, SystemBackdropElement、compact sizing、Binding, INotifyPropertyChanged, ObservableCollection, IValueConverter, DataContext, MVVM、 Storyboard, DoubleAnimation, EasingFunction, ThemeTransition, ConnectedAnimation, ImplicitAnimation、XamlOptionalChanges。

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Windows アプリ開発 (WinUI 3 / Windows App SDK) のコントロール API リファレンス。 Microsoft.UI.Xaml.Controls。Button, CheckBox, RadioButtons, ToggleSwitch, Slider, TextBox, RichEditBox, AutoSuggestBox, NumberBox, ListView, GridView, ItemsView, ItemsRepeater, TreeView, ComboBox, NavigationView, TabView, Frame, SplitView, BreadcrumbBar, ContentDialog, Flyout, CommandBar, TeachingTip, InfoBar, MediaPlayerElement, WebView2, CalendarView, DatePicker, ColorPicker, TitleBar。

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Hermes Agent (Nous Research の AI CLI エージェント)。インストール、 CLI コマンド (chat, model, gateway, config, cron, webhook, mcp, skills, profile, hermes pm)、 Configuration (Terminal Backends, Memory, TTS / STT, Auxiliary Models, Compression, Display, Local Models llama.cpp, Egress / Secrets)、 Features (Tools, Skills, Hooks, Delegation, Kanban, Cron, Voice Mode, Personality, Context Files)、 Messaging Gateway (Platform Support, Bot Mode, Connectors)、Security、Architecture、 Hermes Desktop、Plugin Catalog、Profiles、Developer Guide、Nous Portal (Tool Gateway)。

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TanStack Router (型安全 React ルーター、@tanstack/react-router) の API リファレンス。 React Router (react-router) とは別ライブラリ。 createRouter, createFileRoute, createRootRoute, createLazyFileRoute, createLazyRoute, Link, Outlet, useNavigate, useParams, useSearch, useLoaderData, useBlocker, loader, beforeLoad, validateSearch, redirect, notFound, Await, file-based routing, routeTree.gen.ts, router-plugin, tsr CLI, code splitting, SSR, TanStack Query 統合, eslint-plugin-router。

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AppKit macOS UI リファレンス。Liquid Glass (NSGlassEffectView)、 NSApplication, NSWindow, NSViewController, NSView, NSMenu, NSToolbar, NSTableView, NSOutlineView, NSCollectionView, NSSplitViewController, NSTabView, NSPopover, NSOpenPanel / NSSavePanel, NSSearchField, NSControl, NSStackView, NSScrollView, Diffable Data Source, target-action, responder chain。

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visionOS / iOS 空間コンピューティング。RealityKit、ARKit、visionOS SwiftUI、USDKit、Spatial Preview。 Entity, ModelEntity, AnchorEntity, Component, System, RealityView, MeshResource, Material, EntityAction, MeshDeformerComponent, GaussianSplatComponent, ComputeGraphComponent, ComputeNodeGraph, PhysicsJointsComponent, ForceEffectComponent, ClothBodyComponent, NavigationComponent, NavigationMeshComponent, NavigationController, USDStage, SpatialPreviewSession, ImmersiveSpace, ImmersionStyle, WindowGroup, VolumetricWindowStyle, Model3D, ARKitSession, ARSession, ARWorldTrackingConfiguration, WorldTrackingProvider, HandTrackingProvider, ImageTrackingProvider, AccessoryTrackingProvider, CameraFrameProvider, ObjectTrackingProvider, RoomTrackingProvider, SceneReconstructionProvider。

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Android アプリ開発 (Kotlin) の画面遷移・Navigation リファレンス。 Jetpack Compose, androidx。Navigation 3 (stable, NavDisplay, NavKey, ResultEventBus, DeepLinkMatcher)、 Navigation Compose (NavHost, composable, 型安全ルート)、 Fragment ナビゲーション (NavHostFragment, Safe Args)、ディープリンク, App Links, assetlinks.json、 予測型戻る (OnBackPressedDispatcher)。

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Turn character reference images into reusable, rigged voxel 3D assets for Blender and Three.js through an imagegen turnaround and user-approval workflow. Use when Codex needs to preserve a character's likeness across front, side, and back views; create or revise Minecraft-like cube-headed models; prevent missing rear hair or clothing; split features between block geometry and face/clothing textures; generate GLB and editable .blend files; add walk/smash-compatible rigid-part pivots; or diagnose why a voxel conversion is not recognizable.

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Inventory a person's work history as facts before any document is written, listing each period of employment and what they actually did, splitting every experience into situation, their own actions, outcome, and stated role, and recording what each claim rests on (public record, their own records, someone who was there, or memory alone). Use when a user is starting a job search, needs material for a rirekisho, shokumu-keirekisho, or entry sheet, or wants to find which periods of their history they have never written down; do not use to judge their strengths, aptitude, or market value, to name a job they are suited for, or to write finished application copy.

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Triage a GitHub issue that already has the cc-issue-created label and is assumed ready to start. Inspect the comment history first to decide whether human confirmation is needed (cc-need-human-check, highest priority — reserved for issue-level deadlock, or for confirmation items answer-issue-questions already investigated and explicitly marked unanswerable); otherwise close the issue as not needed, delegate unanswered confirmation items in the last comment or the description to answer-issue-questions (cc-answer-issue-questions), refresh a description stale relative to settled comment-history content (cc-update-issue), turn the issue into an Epic and split it into sub-issues when its work should ship as separate PRs (cc-epic-issue), or move to execution (cc-exec-issue). Any UI-changing issue is routed to the design-first flow (cc-create-ui-design) before execution; the exceptions are an issue whose description already names the .pen design to implement against, and a minor UI change that introduces no new visual decision (no new screen/section, no layout change, no new reusable component, no visual expression outside existing design tokens/components). Design files are never edited in the implementation PR. Dependency checks are out of scope.

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Use when preparing or reviewing an Australian fuel tax credit claim for a plant-operating business: eligibility and registration, the public-road against off-road against auxiliary split, the road user charge and the incidental-travel carve-out, apportionment method and evidence, adjustments against error corrections, and the BAS labels that carry it.

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Work on the Android app — the thin WebView wrapper in `android/`. Use this whenever a task touches the Kotlin sources, the Gradle build, the WebView shell, the native settings screen, LMS server auto-discovery, the JS↔native bridge, app strings/i18n, or the Android CI/lint. Covers the "shell only, UI lives on the web" principle, the debug/release signing split, the static versioning F-Droid needs, and the min/target SDKs, so changes fit the wrapper.

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