23 skills · sorted by relevance
Evaluates ambient context artifacts (CLAUDE.md, memory, local skills, settings hooks) for compatibility with swarm governance. Returns a classified report so users can address interference before launching a team.
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Expert-level optics knowledge. Use when working with geometric optics, wave optics, interference, diffraction, polarization, lasers, fiber optics, optical instruments, or photonics. Also use when the user mentions 'reflection', 'refraction', 'Snell law', 'lens', 'mirror', 'interference', 'diffraction', 'polarization', 'laser', 'fiber optic', 'holography', 'aberration', or 'optical instrument'.
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Troubleshoot WxJava failures using logs, exceptions, and request details. The skill helps isolate configuration, access token, signature, payment certificate, callback, and network issues, then proposes a minimal fix with steps to verify the result.
Diagnose failing or intermittent Playwright tests by reproducing errors and examining execution traces. Classify the cause, apply a targeted fix, and run the test ten times to check stability, with recommendations to prevent recurrence.
Design Redis caching, leaderboards, notifications, and message processing. Helps choose data structures, write Lua scripts for operations that run together without interference, and plan expiration, memory use, and persistence settings.
CRISPR library design for genetic screens. Covers sgRNA selection, library composition, control design, and oligo ordering. Use when designing custom sgRNA libraries for knockout, activation, or interference screens.
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Diagnoses Windows App (Remote Desktop / AVD / W365 / direct PC) connection problems on macOS: transport selection (UDP Shortpath vs WebSocket), VPN/proxy interference, and stuck "Configuring remote PC..." dialogs. Use when a VDI connection is slow/stuck, transport shows WebSocket not UDP, or Windows App freezes at a progress dialog. Not for general network diagnosis (use debugging-network-issues or tunnel-doctor).
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Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.
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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
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Design and validate digital filters in MATLAB. Use when cleaning up noisy signals, removing interference, filtering signals, designing FIR/IIR filters (lowpass/highpass/bandpass/bandstop/notch), or comparing filters in Filter Analyzer.
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Think and work like an expert Computational Social Scientist. Use when a task calls for Computational Social Scientist judgment. Reasons from social mechanisms, measurement validity, and sampling frames through DAGs, fixed-effects and IV/DiD/RDD designs, ERGM/SAOM network models, and human-audited text classifiers while treating unobserved homophily, network interference and SUTVA violations, platform-driven selection, bot contamination, and digital-skew unrepresentativeness as first-class failure modes.
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Harmonize multiple Blender skills into a coherent pipeline with clear activation precedence, handoff artifacts, dependency gates, and conflict-resolution rules. Use when a Blender task spans several skills, when reference-locked work conflicts with generic production workflow, after adding/updating skills, or when repeated failures indicate skill interference or missing inter/intra-play.
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Systematically interpret Raman spectra to identify molecular vibrations, assess polarizability-driven selection rules, compare with complementary IR data, and evaluate depolarization ratios for symmetry assignment. Covers Raman-active mode identification, fluorescence interference mitigation, and reference spectrum matching.
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Analyze Ascend NPU schedule, operator dispatch, operator launch, and Host Bound profiling issues in Ascend profiling data. Use when need to diagnose device Free time, framework/operator dispatch latency, launch latency, PYTORCH_API/CANN_API launch gaps, aclrtSynchronizeStream stalls, task queue behavior, CPU scheduling interference, GC/lock pauses, CPU affinity, or schedule-side optimization actions.
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Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.
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Recommends switching specific anti-hypertensive medications to reduce false-positive and false-negative screening results for primary aldosteronism. Triggered when a clinician notes 'The patient is on ACE inhibitors/ARBs' or suspects medication interference with screening results.
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Recommends withdrawing interfering medications and repeating aldosterone-to-renin ratio screening when initial screen is negative but clinical suspicion remains due to hypokalemia or medication interference. Trigger phrases include "initial screen negative", "hypokalemia", "resistant hypertension", and use of MRAs, ACE inhibitors, ARBs, beta-blockers, clonidine, or alpha-methyldopa.
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Repair and triage guide for the NV oOS PHPUnit test suite — Docker test environment (incl. cross-worktree one-off runners), CI log triage, and 71 recurring root-cause patterns (hook resets, singleton interference, WP_Error envelope drift, coverage-manifest drift, preset-accounting gaps, and more — see the patterns section). Covers the cluster-by-cluster PR workflow against alpha-working and validation gates. Use when fixing failing PHPUnit tests, triaging CI logs, repairing test drift, deciding between a production fix and a test fix, or starting a new fix cluster.
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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
The English summary is being prepared. Showing the original description.
Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.
The English summary is being prepared. Showing the original description.
Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
The English summary is being prepared. Showing the original description.
Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.
The English summary is being prepared. Showing the original description.
Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
The English summary is being prepared. Showing the original description.