19 skills · sorted by relevance
Set up 3 remote control modes for Claude Code CLI — local iTerm pair hacking, Discord bot for mobile control, and tmux multi-pane multi-target workflows. Includes dangerouslySkipPermissions security hardening. Based on Critical Thinking Bug Bounty Podcast Episode 166.
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Compound-target-disease network construction and analysis for drug repurposing, polypharmacology discovery, and multi-target drug design. Uses STRING, BioGRID, ChEMBL, DGIdb, OMIM, OpenTargets. Use for off-target effect prediction, network-based drug repurposing, and identifying molecules with desired multi-target profile.
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Refactor C#/.NET code through renaming, extraction, consolidation, and other structural changes while preserving behavior. Check compatibility beyond code references, including public APIs and serialized names, then validate with builds and relevant tests.
Investigate MSBuild failures caused by projects or build configurations writing to the same output folders. Compare build logs, output paths, and project settings to identify collisions behind overwritten files, restore errors, or failures that disappear on retry.
Build game cameras that feel good — 2D follow with a deadzone, look-ahead, smoothing, and level-bounds clamping; 3D third-person orbit with collision and first-person look; plus multi-target framing and a shake hook. Engine-neutral techniques that pair with the engine's camera node and rigs like Unity Cinemachine or Godot Camera2D/PhantomCamera. Use when the user mentions camera follow, follow camera, deadzone, look-ahead, camera smoothing, camera bounds/ limits, third-person camera, orbit camera, first-person look, Cinemachine, or camera jitter.
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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF calibration (BF >6 ≈ 90% posterior per Hart 2017; ~5% FDR by BAGEL convention). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.
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Build, review, or improve Core Data persistence in apps that have not adopted SwiftData. Use when working with NSManagedObject subclasses, NSFetchedResultsController for list-driven UI, NSBatchInsertRequest / NSBatchDeleteRequest / NSBatchUpdateRequest for bulk operations, NSPersistentHistoryChangeRequest for persistent history tracking and multi-target sync, NSStagedMigrationManager for staged schema migrations (iOS 17+), NSCompositeAttributeDescription for composite attributes (iOS 17+), or when integrating Core Data threading with Swift Concurrency. For Core Data + SwiftData coexistence or migration, see the swiftdata skill instead.
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Detects MSBuild projects with conflicting OutputPath or IntermediateOutputPath. USE FOR: builds failing with 'Cannot create a file when that file already exists', 'The process cannot access the file because it is being used by another process', intermittent build failures that succeed on retry, or missing/overwritten outputs in multi-project or multi-targeting builds where bin/obj (or project.assets.json) collide. Common causes: shared OutputPath, missing AppendTargetFrameworkToOutputPath, extra global properties (e.g. PublishReadyToRun), or SetTargetFramework on a ProjectReference to a single-targeting project. DO NOT USE FOR: file access errors unrelated to MSBuild (OS-level locking), single-project single-TFM builds, non-MSBuild build systems.
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Safely refactors C#/.NET code without changing behavior. USE FOR any request to refactor, rename, move, extract, inline, merge, consolidate, deduplicate, split, or modernize C# code, including partial/generated declarations, wrappers, public APIs, serialization/reflection/configuration names, friend assemblies, conditional compilation, and multi-targeted projects. Also use when a request calls a feature, bug fix, package/framework upgrade, or public nullability change a refactor and the behavior-changing part must be separated or declined. DO NOT USE FOR ordinary feature or bug fixes not presented as refactoring; standalone upgrades after reclassification (use dotnet-upgrade); adding tests; or formatting-only work.
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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.
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Hotwire Turbo for Symfony UX -- SPA-like speed with zero JavaScript. Covers Drive (navigation), Frames (partial page sections), and Streams (multi-target updates). Use when building ajax navigation, lazy-loaded sections, inline editing, pagination without reload, modals from the server, flash messages via streams, or real-time updates via Mercure/SSE. Code triggers: turbo-frame, turbo-stream, data-turbo-frame, data-turbo, data-turbo-action, turbo-stream-source, TurboStreamResponse, <twig:Turbo:Frame>, <twig:Turbo:Stream:Append>, <twig:Turbo:Stream:Replace>, turbo:before-fetch-request. Also trigger when the user asks "how to update part of the page without reload", "how to make navigation feel like SPA", "how to lazy-load a section", "how to do inline editing", "how to push real-time updates from server", "how to use Mercure with Turbo". Do NOT trigger for client-side JS behavior (use stimulus), server-rendered reactive components (use live-component), or reusable static UI (use twig-component).
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.NET SDK and NuGet tooling conventions: dotnet CLI commands (new/build/run/test/publish/restore/format), NuGet package management (PackageReference, Directory.Packages.props central package management, packages.lock.json), project file conventions (.csproj, .sln, global.json, Directory.Build.props), multi-targeting, and dotnet format. Stack-agnostic — referenced by every .NET plugin in the marketplace. Use this skill to: - Detect the .NET SDK version and run all commands via the dotnet CLI. - Manage NuGet dependencies safely (central package management, no floating versions). - Configure project files and solution-wide properties in Directory.Build.props. - Format code consistently with dotnet format. Do NOT use this skill for: - Framework-specific tooling (dotnet ef migrations, aspnet-codegenerator — those are in aspnet-core-plugin:aspnet-conventions). - Testing patterns — see csharp-foundation:dotnet-testing. - C# language idioms — see csharp-foundation:csharp-conventions.
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Build a plugin or adapter for a CLI tool using the abstract base class pattern. Covers defining the contract (static fields, required methods), choosing an installation strategy (symlink, copy, append-to-file), implementing detection, install/uninstall with idempotency, listing, auditing, and registering the plugin. Use when adding support for a new framework to a CLI installer, building a plugin system for any multi-target tool, or extending an existing adapter architecture.
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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF calibration (BF >6 ≈ 90% posterior per Hart 2017; ~5% FDR by BAGEL convention). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.
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Autonomous driver loop for ExploitHunter vulnerability-research campaigns. Runs breadth-first waves of research lanes on rented hosts with no per-request human approval, steers lanes via the shared Investigation Graph (demoting dead ends, respawning on high-signal priorities), saturates host capacity, and enforces wave/budget/safety discipline. Use when driving a multi-target bug-hunting campaign, launching parallel research lanes, or resuming a campaign from a state snapshot.
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Detects MSBuild projects with conflicting OutputPath or IntermediateOutputPath. Only activate in MSBuild/.NET build context. USE FOR: builds failing with 'Cannot create a file when that file already exists', 'The process cannot access the file because it is being used by another process', intermittent build failures that succeed on retry, missing outputs in multi-project builds, multi-targeting builds where project.assets.json conflicts. Diagnoses when multiple projects or TFMs write to the same bin/obj directories due to shared OutputPath, missing AppendTargetFrameworkToOutputPath, or extra global properties like PublishReadyToRun creating redundant evaluations. DO NOT USE FOR: file access errors unrelated to MSBuild (OS-level locking), single-project single-TFM builds, non-MSBuild build systems. INVOKES: binlog MCP server tools (overview, projects, evaluations, properties, double_writes); falls back to dotnet msbuild binlog replay + grep when the MCP is unavailable.
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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.
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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.
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Targets multiple TFMs via polyfills and conditional compilation. PolySharp, API compat.
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