Results for “pth”

Computes and interprets sequencing read depth and coverage over a genome, windows, or target regions with mosdepth (windowed depth, cumulative distribution, --quantize callable BEDs), bedtools genomecov/coverage (bedGraph tracks, per-target stats), samtools depth/coverage (per-base depth, per-contig depth+breadth). Covers the breadth-vs-mean distinction, the cumulative-coverage curve, evenness (CV/Fano/fold-80/Gini), what each tool silently counts (duplicates, secondary/supplementary, MAPQ, read span vs fragment, mate-overlap), the samtools-depth 8000-cap version trap, and the bedtools coverage -a/-b orientation flip. Use when assessing sequencing adequacy, building coverage tracks, computing breadth at a depth threshold, defining callable regions, or QCing target-capture uniformity.

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Computes and interprets sequencing read depth and coverage over a genome, windows, or target regions with mosdepth (windowed depth, cumulative distribution, --quantize callable BEDs), bedtools genomecov/coverage (bedGraph tracks, per-target stats), samtools depth/coverage (per-base depth, per-contig depth+breadth). Covers the breadth-vs-mean distinction, the cumulative-coverage curve, evenness (CV/Fano/fold-80/Gini), what each tool silently counts (duplicates, secondary/supplementary, MAPQ, read span vs fragment, mate-overlap), the samtools-depth 8000-cap version trap, and the bedtools coverage -a/-b orientation flip. Use when assessing sequencing adequacy, building coverage tracks, computing breadth at a depth threshold, defining callable regions, or QCing target-capture uniformity.

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Computes and interprets sequencing read depth and coverage over a genome, windows, or target regions with mosdepth (windowed depth, cumulative distribution, --quantize callable BEDs), bedtools genomecov/coverage (bedGraph tracks, per-target stats), samtools depth/coverage (per-base depth, per-contig depth+breadth). Covers the breadth-vs-mean distinction, the cumulative-coverage curve, evenness (CV/Fano/fold-80/Gini), what each tool silently counts (duplicates, secondary/supplementary, MAPQ, read span vs fragment, mate-overlap), the samtools-depth 8000-cap version trap, and the bedtools coverage -a/-b orientation flip. Use when assessing sequencing adequacy, building coverage tracks, computing breadth at a depth threshold, defining callable regions, or QCing target-capture uniformity.

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Find recent earthquakes by date and minimum magnitude, then review their location, depth, and USGS source. World Monitor also provides a concern score combining magnitude, depth, and proximity to known nuclear test sites.

• Review recent earthquakes above a chosen magnitude
• Check earthquake locations and depths within a date range
• Inspect events near known nuclear test sites

Write and improve C code for systems and embedded projects, with explicit memory ownership, pointer handling, and error checks. The skill also covers build files, unit tests, debugging, and performance measurement.

• Reviewing memory allocation and cleanup in C code
• Writing embedded code with limited memory
• Implementing threading with pthreads

Analyze images, video, speech, motion, products, and websites; route local vision, audio, depth, tracking, matting, identity, and restoration models; auto-edit, replicate, enhance, caption, voice, assemble, annotate, validate, and export editable Timeline Studio projects and videos. Use for reference-video remakes, filter and repeated-shot reconstruction, subject-aware reframing, clip splitting, source-time speed curves, Color Wheels grading, ramps and holds, person or product cutout, person or object outline, authorized face swap, shot and timing reconstruction, timeline markers, chapters, beat cues, review notes and ranges, supplied or web-sourced footage, AI video platform selection, cleanup, highlights, product promotion, website walkthroughs, image-to-video assisted edits, optical-flow editing, depth-assisted relighting, grayscale depth-video conversion, depth/2.5D/transition finishing, AI voiceover, subtitles, short-form production, .timeline automation, or editor evaluation.

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Captions living in 3D space around a talking head: a camera flies between the speaker and the words (whip-in, parallax truck, push), caption groups sit at different depths so camera moves pull them apart, hero words hide BEHIND the speaker through an alpha matte, a ring of words wraps round the speaker and turns in front of them, focus racks between depths, and text steps at 15 fps with ghost motion blur. Works in any type style (editorial serif, bold sans) or hand-drawn (p5.brush write-on). Trigger on: "3D text", "3D camera captions", "text around / behind the speaker", "camera moves through the text", "depth captions on my avatar video". Covers prep (portion, padded plate, matte, word clock, font metrics), the shot grammar, depth rules, QC, and limits.

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Use when a task needs the judgment of a Dredge Operator — selecting cutterhead, hopper, or mechanical dredge type for a given sediment/depth/environmental profile, classifying dredged material for open-water vs. confined disposal from sediment-testing results, tuning hydraulic slurry density against pipeline critical velocity, verifying channel controlling depth against project depth and overdepth tolerance, or setting turbidity-monitoring response during active dredging.

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Work up a patient with confirmed hypercalcemia using the PTH-dependent vs. PTH-independent algorithm — order the right second-tier tests (PTHrP, 25(OH)D, 1,25(OH)2D, SPEP/UPEP, urinary calcium/creatinine clearance ratio, TSH) to reach a diagnosis. Trigger when a clinician asks "what's causing this hypercalcemia", "how to work up high calcium", "what tests to order for hypercalcemia", "PTH is normal what next", "differential diagnosis of hypercalcemia", or shares a confirmed hypercalcemia and asks for the workup.

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Work up Malignancy-Associated Hypercalcemia (MAH) — distinguish humoral hypercalcemia of malignancy (HHM, PTHrP-driven), local osteolytic hypercalcemia, 1,25(OH)2D-mediated lymphoma hypercalcemia, ectopic PTH secretion, and multiple myeloma — and pick the right confirmatory tests and therapy direction. Trigger when a clinician asks "is this hypercalcemia from cancer", "PTHrP positive what now", "hypercalcemia in lung cancer / breast cancer / lymphoma / myeloma", "humoral hypercalcemia of malignancy", "MAH workup", or any hypercalcemia case with suppressed PTH and a known or suspected malignancy.

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Analyze prompts and offer depth / token-budget options BEFORE answering. Use this skill when the user wants to control token usage, tune response depth, choose between short and long answers, or optimize their prompt. Triggers on: "tokens", "token budget", "depth", "consumption", "short vs long answer", "how many tokens", "save tokens", "answer at 50%", "give me the short version", "I want to control how much you use", "tune your response", "presupuesto de tokens", "profundidad", "responde al 50%", "dame la versión corta", or any equivalent phrasing in English or Spanish. If the user wants to control length, detail or depth -- even without mentioning tokens explicitly -- this skill applies.

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Check a codebase for known dependency vulnerabilities, hard-coded secrets, and risky code patterns using Ruflo security tools. Choose a scan depth, inspect matching lines, and report verified concerns with a clear account of what was checked.

• Checking pull requests for security regressions
• Inspecting authentication and input-handling code for risky patterns
• Running security checks before production deployment

Represent dependency trees, taxonomies, and other hierarchies inside a Poincare ball, a geometric model for hierarchical distances. Use tree depth for radius and text embeddings for direction, then measure distances to examine the encoded structure.

• Analyze subtrees in module dependencies
• Examine structural patterns in class hierarchies
• Organize concepts by taxonomic relationships

Add an eight-second HyperFrames headline animation where square tiles lift, tilt, and flip to reveal a second message. Customize both headlines and 18 settings covering tile size, sweep direction, timing, depth, bounce, and shadows.

• Reveal a second headline through flipping tiles
• Create an animated opening for a promotional video
• Adjust tile depth and shadows to suit a design

Generate a customizable AI prompt for finding representative examples in an existing codebase. Configure analysis depth, categories, and snippets so GitHub Copilot can produce exemplars.md with real file references and explanations of coding conventions.

• Collecting existing code examples for team guidance
• Documenting patterns to follow when adding features
• Configuring the depth and format of a code example guide

Build websites with layered depth, scroll-driven transitions, and animated text using static images, CSS, and JavaScript. The skill covers asset inspection, visual planning, implementation, and checks for performance and motion accessibility.

• Build a product landing page with scroll-driven effects
• Add layered depth and animated text to an existing site
• Inspect image transparency and plan asset placement

Add subtle mouse-responsive depth to a Three.js hero scene. Smooth pointer movement drives small camera shifts and different object rotations, keeping the subject aligned with nearby text and cards while creating a gentle sense of perspective.

• Add subtle mouse response to a 3D hero
• Give foreground and background different movement
• Keep a moving model aligned with text and cards

Guide for theming .NET MAUI apps — light/dark mode via AppThemeBinding, ResourceDictionary theme switching, DynamicResource bindings, system theme detection, and user theme preferences. Use when: "dark mode", "light mode", "theming", "AppThemeBinding", "theme switching", "ResourceDictionary theme", "dynamic resources", "system theme detection", "color scheme", "app theme", "DynamicResource". Do not use for: localization or language switching (see .NET MAUI localization documentation), accessibility visual adjustments (see .NET MAUI accessibility documentation), app icons or splash screens (see .NET MAUI app icons documentation), or Bootstrap-style class theming (see Plugin.Maui.BootstrapTheme NuGet package).

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Real-time depth map privacy transforms using Depth Anything v2 (CoreML + PyTorch)

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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.

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Expert Godot shader patterns for batch-safe hitflash, alpha-scissor foliage/dissolve, screenspace postFX, depth reconstruction, triplanar, and instance uniforms — not first-shader tutorials. Trigger on draw-call batching breaks, discard vs depth-prepass, foliage shadows, post-process quads, or world-position FX. Keywords: instance uniform, ALPHA_SCISSOR, hint_screen_texture, hint_depth_texture, global uniform, sampler2DArray, canvas_item, spatial, post-processing.

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Expert patterns for simplifying 3D games to 2D including dimension reduction strategies, 2.5D fake-depth, isometric ports, camera flattening, physics conversion, 3D-to-sprite art pipeline, and control simplification. Use when porting 3D to 2D, building 2.5D / isometric / fake-depth gameplay, creating 2D versions for mobile, or prototyping. Trigger keywords: CharacterBody3D to CharacterBody2D, Camera3D to Camera2D, Vector3 to Vector2, flatten Z-axis, 2.5D, isometric, fake depth, Y-sort, simulated Z, orthogonal projection, 3D to sprite conversion, performance optimization.

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Expert Godot shader patterns for batch-safe hitflash, alpha-scissor foliage/dissolve, screenspace postFX, depth reconstruction, triplanar, and instance uniforms — not first-shader tutorials. Trigger on draw-call batching breaks, discard vs depth-prepass, foliage shadows, post-process quads, or world-position FX. Keywords: instance uniform, ALPHA_SCISSOR, hint_screen_texture, hint_depth_texture, global uniform, sampler2DArray, canvas_item, spatial, post-processing.

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Expert patterns for simplifying 3D games to 2D including dimension reduction strategies, 2.5D fake-depth, isometric ports, camera flattening, physics conversion, 3D-to-sprite art pipeline, and control simplification. Use when porting 3D to 2D, building 2.5D / isometric / fake-depth gameplay, creating 2D versions for mobile, or prototyping. Trigger keywords: CharacterBody3D to CharacterBody2D, Camera3D to Camera2D, Vector3 to Vector2, flatten Z-axis, 2.5D, isometric, fake depth, Y-sort, simulated Z, orthogonal projection, 3D to sprite conversion, performance optimization.

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