38 skills · sorted by relevance
Drug and chemical toxicity assessment via adverse outcome pathways (AOPs), real-world FAERS adverse event signals, FDA labels, and toxicogenomic associations. Triangulates molecular initiating event to cellular outcome to organ-level toxicity to clinical adverse event. Use for hepatotoxicity/cardiotoxicity/nephrotoxicity prediction and toxicology reports.
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Chemical safety and toxicology assessment integrating ADMET-AI predictions, CTD toxicogenomics, PubChemTox experimental data, GHS/IARC hazard classification, and exposure-context analysis. Use for chemical hazard identification, occupational/consumer-product toxicity, dose-response evaluation, and acute (LD50) vs chronic toxicity assessment. Distinguishes drug toxicity from environmental chemical toxicity.
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ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) prediction for drug candidates. Use for assessing drug-likeness, PK properties, and safety risks early in drug discovery. Keywords: ADMET, PK, toxicity, drug-likeness, DILI, hERG, bioavailability
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Comprehensive ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiling for drug candidates. Integrates ADMET-AI predictions, SwissADME drug-likeness, PubChemTox experimental toxicity, ChEMBL clinical data, Lipinski rule-of-five, and CYP interaction data. Use for drug-likeness assessment, BBB penetration, bioavailability, hepatotoxicity prediction, ADME/PK profiling, or screening compound libraries before lab testing.
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Build molecular property prediction workflows with DeepChem for solubility, toxicity, and related chemistry tasks. Prepare molecular representations, choose compatible models, handle missing labels, and evaluate predictions using data splits designed for the intended scientific question.
Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.
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Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.
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Analyze bid–ask spreads, order books, and buying and selling imbalances to assess liquidity, or how easily an asset trades. Estimate large-order price impact and transaction costs, with additional guidance on Chinese A-share auction and block trades.
Configure safety checks for LLM applications with NeMo Guardrails. Covers attempts to bypass safety rules, input and output validation, masking personal information, and checking factual claims through programmable rules and integrations.
Add safety checks to LLM applications with NeMo Guardrails. This skill guides input and output validation, detection of attempts to bypass safety rules, personal information masking, and checks for unsupported or inaccurate answers.
Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted safety.
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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.
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Molecular machine learning toolkit. Property prediction (ADMET, toxicity), GNNs (GCN, MPNN), MoleculeNet benchmarks, pretrained models, featurization, for drug discovery ML.
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Therapeutics Data Commons (TDC) AI-ready drug discovery datasets. Curated ADME, toxicity, DTI, DDI with scaffold/cold splits, standardized metrics, molecular oracles, and ADMET benchmarks for therapeutic ML and property prediction. For chemical database queries use chembl-database-bioactivity; for featurization use molfeat.
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Think and work like an expert Molecular Biologist. Use when a task calls for Molecular Biologist judgment. Reasons from central-dogma sequence flow, binding affinity (Kd/Km/kcat), gene regulation, and biological-versus-technical replicate structure through MIQE-compliant RT-qPCR, ddPCR, Western/flow/microscopy, CRISPR editing with rescue, and IWGAV antibody validation while treating off-target reagent effects, batch effects, mycoplasma and cell-line misidentification, and toxicity-driven artifacts as first-class failure modes.
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Think and work like an expert Gerontologist. Use when a task calls for Gerontologist judgment. Reasons from senescence hallmarks, frailty, multi-morbidity, and life-course exposures through validated instruments (Fried phenotype, Rockwood CFS, SPPB/gait speed), epigenetic clocks (Horvath, PhenoAge, GrimAge), competing-risk survival (Fine-Gray), and NIA cohorts (HRS, NHATS, ITP) while treating survivor bias, differential attrition, healthy-volunteer bias, and frail-subset toxicity as first-class failure modes.
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Think and work like an expert Functional Genomics Scientist. Use when a task calls for Functional Genomics Scientist judgment. Reasons from perturbation as causal probe, genotype-to-phenotype linkage, library representation, and effect-size-plus-FDR statistics through MAGeCK/BAGEL/CERES-Chronos, CRISPRcleanR, CRISPResso2, MPRAnalyze, and Perturb-seq pipelines while treating MOI/bottleneck artifacts, copy-number and p53/DSB toxicity, RNAi seed effects, and guide-assignment or gating errors as first-class failure modes.
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Think and work like an expert Developmental Biologist. Use when a task calls for Developmental Biologist judgment. Reasons from stage, positional information, gene regulatory networks, and tissue mechanics through morphology-based staging (Carnegie/HH/Theiler/NF/hpf), French-flag morphogen logic, light-sheet 4D imaging, lineage tracing, and ARRIVE/MDAR/REMBI reporting while treating developmental delay, CRISPR F0 mosaicism, morpholino p53 toxicity, and conflated fate-versus-lineage claims as first-class failure modes.
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Think and work like an expert Biomaterials Scientist. Use when a task calls for Biomaterials Scientist judgment. Reasons from material-biology interfaces, degradation-product toxicity, and mechanical mismatch to host tissue through ISO 10993 biological evaluation plans, ISO 10993-12 extract conditions, GPC/ICP/SEM characterization, and sterilization validation while treating endotoxin contamination, pH shift from acidic degradation, extract-ratio artifacts, and non-final-form test articles as first-class failure modes.
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Think and work like an expert Anesthesiologist. Use when a task calls for Anesthesiologist judgment. Reasons from control of consciousness, analgesia, autonomic response, and oxygen delivery through the ASA Difficult Airway Algorithm, capnography and arterial-waveform trends, quantitative TOF monitoring, and ASRA/ERAS protocols while treating cannot-ventilate airways, local anesthetic systemic toxicity, malignant hyperthermia, and residual neuromuscular blockade as first-class failure modes.
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Use Amazon Transcribe for AWS-based speech-to-text production: batch S3 transcription, real-time streaming, captions/subtitles, diarization, channel identification, custom vocabularies, vocabulary filters, language identification, PII/PHI handling, toxicity detection, Call Analytics, Medical, and secure S3/IAM/KMS workflows.
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Add fast, local, typed decisions to any project with Laya, an open-source non-generative decision model (pip install laya). It classifies, routes, scores and answers yes/no questions about a piece of text, returning calibrated probabilities in roughly 20-35 ms on a laptop GPU, with no LLM call and no data leaving the machine. Use this skill whenever the user wants to classify or route text, triage tickets or emails, detect spam, phishing, toxicity or intent, put a guardrail in front of an agent or LLM, score something against a rubric, or replace an LLM-based classifier to cut latency or cost. Also use it when they mention Laya, Jev, a "System 1 model", "typed decisions" or a "decision model", even if they never name Laya.
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Backlink profile audit via the DataForSEO Backlinks API. Returns total backlinks, referring domains, dofollow ratio, top anchors with over-optimization flags, top referring domains by authority, and a toxicity assessment with an Authority Score (0-100).
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Evaluates alternative trading systems with fill rate analysis, information leakage assessment, and venue toxicity measurement. Use when analyzing dark pools, evaluating ATS venues, or assessing execution venue quality.
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