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uniprot-skill

Search UniProt protein records by gene or identifier and receive concise summaries. The skill supports UniProtKB, UniRef, and UniParc lookups, with optional file saving for full JSON records or FASTA, a text format for biological sequences.

OriginalShow the original description

Submit compact UniProt REST API requests for UniProtKB, UniRef, UniParc, and FASTA stream endpoints. Use when a user wants concise UniProt summaries; save raw JSON or FASTA only on request.

See how to install

Good for

  • Find protein records by gene and organism
  • Look up a protein by its accession
  • Inspect UniRef clusters and UniParc records
  • Save full JSON records or FASTA sequences

Files included (3)

  • SKILL.md2.7 KB
  • agents/openai.yaml84 B
  • scripts/rest_request.py10.5 KB

SKILL.md (original)

Review the instructions the agent will receive before you install.

Operating rules

  • Use scripts/rest_request.py for all UniProt API calls.
  • Use base_url=https://rest.uniprot.org.
  • The script accepts max_items; for search endpoints, start with API size=10 and max_items=10.
  • Single accession or cluster lookups usually do not need max_items.
  • Re-run requests in long conversations instead of relying on older tool output.
  • Treat displayed ... in tool previews as UI truncation, not part of the real request.
  • If the user asks for full JSON or FASTA, set save_raw=true and report the saved file path instead of pasting the payload into chat.

Execution behavior

  • Return concise markdown summaries from the script JSON by default.
  • Return the script JSON verbatim only if the user explicitly asks for machine-readable output.
  • Prefer these paths: uniprotkb/search, uniprotkb/<accession>, uniref/<cluster>, uniparc/search, and uniprotkb/stream.
  • For stream, use response_format=text so the script returns only a short text_head unless raw output is requested.

Input

  • Read one JSON object from stdin.
  • Required fields: base_url, path
  • Optional fields: method, params, headers, json_body, form_body, record_path, response_format, max_items, max_depth, timeout_sec, save_raw, raw_output_path
  • Common UniProt patterns:
    • {"base_url":"https://rest.uniprot.org","path":"uniprotkb/search","params":{"query":"gene:TP53 AND organism_id:9606","fields":"accession,gene_names","size":10,"format":"json"},"record_path":"results","max_items":10}
    • {"base_url":"https://rest.uniprot.org","path":"uniprotkb/P04637","params":{"format":"json"}}
    • {"base_url":"https://rest.uniprot.org","path":"uniprotkb/stream","params":{"query":"organism_id:562","format":"fasta","size":2},"response_format":"text"}

Output

  • Success returns ok, source, path, method, status_code, warnings, and either compact records, a compact summary, or text_head.
  • Use raw_output_path when save_raw=true.
  • Failure returns ok=false with error.code and error.message.

Execution

echo '{"base_url":"https://rest.uniprot.org","path":"uniprotkb/search","params":{"query":"gene:TP53 AND organism_id:9606","fields":"accession,gene_names","size":10,"format":"json"},"record_path":"results","max_items":10}' | python scripts/rest_request.py

References

  • No additional runtime references are required; keep the import package limited to this file and scripts/rest_request.py.

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