K-Dense

Retrieve and combine protein annotations, biological pathways, and chemical identifiers from services such as UniProt, KEGG, and UniChem using Python. Supports cross-database lookups and batch identifier conversion while preserving multiple matches and failed requests.

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• Collect protein sequences and functional annotations
• Retrieve pathway information for genes
• Match compound identifiers across databases

Process next-generation sequencing data with deepTools: convert alignment files into coverage tracks, normalize signals, compare samples, and check quality. Create heatmaps and profiles around genes or peak regions for ChIP-seq, RNA-seq, and ATAC-seq experiments.

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• Converting BAM files to normalized bigWig tracks
• Checking sequencing quality and replicate agreement
• Plotting heatmaps around transcription start sites

Generate photos, illustrations, logos, and presentation visuals through the OpenRouter Image API. Edit or combine reference images, choose among supported models, and check available settings such as resolution, output format, and transparency before generation.

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• Creating illustrations and visuals for slides or posters
• Editing colors or styles in existing images
• Combining multiple reference images

Use COBRApy to model metabolic networks and calculate possible reaction flows under defined constraints. Compare gene knockouts, nutrient conditions, and production limits, while checking model validity and keeping computational predictions separate from experimental findings.

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• Calculating metabolic reaction flows and their possible ranges
• Comparing predicted effects of gene knockouts
• Exploring minimal media and production limits

Use Dask to process tables, numerical arrays, and file collections in pieces across CPU cores or machines. Helps choose data structures, size memory-friendly chunks, coordinate dependent tasks, and diagnose slow or memory-heavy workflows.

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• Aggregate CSV or Parquet files that exceed available memory
• Process large scientific arrays in chunks
• Clean JSON records and logs before analysis

Analyze DepMap cancer model data to rank genes required for cell survival, compare groups defined by biological markers, and explore drug responses. Release tracking and statistical checks help organize evidence for research hypotheses.

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• Ranking gene dependencies in cancer models
• Comparing groups defined by biological markers
• Finding genes with similar dependency patterns

Investigate how DNA variants may affect gene activity using precomputed AlphaGenome Atlas results and model predictions. Rank candidate variants, examine tissue-specific effects, and inspect the features behind scores to develop research hypotheses about biological mechanisms.

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• Ranking candidate variants from a VCF
• Examining tissue-specific effects on gene activity
• Comparing reference and altered DNA predictions

Analyze existing evolutionary trees and other hierarchical trees with ETE 4. Edit branches, add annotations, compare branching structures, explore large trees interactively, and render figures for publication using the appropriate optional visualization components.

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• Prune selected species and change a tree's root
• Compare branching structures between two trees
• Add NCBI or GTDB taxonomy information

Process DNA, RNA, and protein sequences with Biopython, convert biological files, and retrieve NCBI records. Supports batch workflows for sequence comparison, searches for similar sequences, protein structure analysis, and evolutionary trees.

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• Convert GenBank files to FASTA
• Calculate sequence length and GC content in batches
• Retrieve sequences and publication records from NCBI

Draft, revise, and audit scientific manuscripts or reports with explicit evidence provenance, reporting-guideline coverage, authorship accountability, confidentiality controls, and local consistency checks. Use for manuscript sections, references, declarations, tables, figures, or submission preparation when scientific accuracy and traceability matter.

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Create publication-quality scientific diagrams using Nano Banana 2 AI with smart iterative refinement. Uses Gemini 3.6 Flash for quality review. Only regenerates if quality is below threshold for your document type. Specialized in neural network architectures, system diagrams, flowcharts, biological pathways, and complex scientific visualizations.

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Build slide decks and presentations for research talks. Use this for making PowerPoint slides, conference presentations, seminar talks, research presentations, thesis defense slides, or any scientific talk. Provides slide structure, design templates, timing guidance, and visual validation. Works with PowerPoint and LaTeX Beamer.

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Evaluate scientific claims and evidence quality. Use for assessing experimental design validity, identifying biases and confounders, applying evidence grading frameworks (GRADE, Cochrane Risk of Bias), or teaching critical analysis. Best for understanding evidence quality, identifying flaws. For formal peer review writing use peer-review.

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Prepare journal manuscripts, conference papers, research posters, and grant documents using venue-specific formatting guidance and bundled LaTeX scaffolds. Use when selecting an official template, checking current page or anonymity rules, adapting academic writing to a venue, or inspecting a submission PDF.

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Compile current scholarly evidence for a scientific manuscript or research brief. Use when the user explicitly asks to gather literature, references, background evidence, competing findings, or a manuscript research packet. Uses Parallel Search by default, Parallel Extract for source verification, Parallel Research for explicitly deep/exhaustive work, optional explicit Parallel Chat, and optional Perplexity only when requested or allowed as a failure fallback.

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Provide qualitative-first, evidence-traceable developmental review of scholarly works and audit low-stakes research-assessment rubrics with optional local quality controls. Never use for ranking people or consequential decisions.

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Use this skill whenever the user wants to create, read, edit, or manipulate Word documents (.docx files) or Word templates (.dotx files). Triggers include: any mention of 'Word doc', 'word document', '.docx', '.dotx', or requests to produce professional documents with formatting like tables of contents, headings, page numbers, or letterheads. Also use when extracting or reorganizing content from .docx or .dotx files, inserting or replacing images in documents, performing find-and-replace in Word files, working with tracked changes or comments, or converting content into a polished Word document. If the user asks for a 'report', 'memo', 'letter', 'template', or similar deliverable as a Word or .docx file, use this skill. Do NOT use for PDFs, spreadsheets, Google Docs, or general coding tasks unrelated to document generation.

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Create professional research posters in LaTeX using beamerposter, tikzposter, or baposter. Support for conference presentations, academic posters, and scientific communication. Includes layout design, color schemes, multi-column formats, figure integration, and poster-specific best practices for visual communication.

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Comprehensive citation management for academic research. Search OpenAlex, PubMed, and Google Scholar for papers, extract accurate metadata, validate citations, and generate properly formatted BibTeX entries. This skill should be used when you need to find papers, verify citation information, convert DOIs to BibTeX, or ensure reference accuracy in scientific writing.

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Conduct comprehensive, systematic literature reviews using multiple academic databases (PubMed, arXiv, bioRxiv, Semantic Scholar, etc.). This skill should be used when conducting systematic literature reviews, meta-analyses, research synthesis, or comprehensive literature searches across biomedical, scientific, and technical domains. Creates professionally formatted markdown documents and PDFs with verified citations in multiple citation styles (APA, Nature, Vancouver, etc.).

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Use this skill whenever the user wants to do anything with PDF files. This includes reading or extracting text/tables from PDFs, combining or merging multiple PDFs into one, splitting PDFs apart, rotating pages, adding watermarks, creating new PDFs, filling PDF forms, encrypting/decrypting PDFs, extracting images, and OCR on scanned PDFs to make them searchable. If the user mentions a .pdf file or asks to produce one, use this skill.

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Convert heterogeneous documents and selected URIs to Markdown with Microsoft MarkItDown for text analysis, search, and LLM/RAG ingestion. Covers safe local conversion, streams, Office/PDF/data formats, batch workflows, plugins, vision OCR, Azure extraction, and the official MCP server.

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Use Parallel CLI for web search, URL extraction, deep research, structured data enrichment, entity discovery, and recurring web monitoring. Best for requests that explicitly need current web evidence, academic-source discovery, repeated entity lookups, exhaustive reports, or ongoing change tracking.

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Create safety-bounded draft structures and run local deterministic checks for clinical case, diagnostic, trial, safety, and aggregate research reports. Use only with synthetic, de-identified, or aggregate inputs and verified source-fact manifests; every output requires qualified review.

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