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This skill should be used at the start of any computationally intensive scientific task to detect and report available system resources (CPU cores, GPUs, memory, disk space). It creates a JSON file with resource information and strategic recommendations that inform computational approach decisions such as whether to use parallel processing (joblib, multiprocessing), out-of-core computing (Dask, Zarr), GPU acceleration (PyTorch, JAX), or memory-efficient strategies. Use this skill before running analyses, training models, processing large datasets, or any task where resource constraints matter.

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当用户开始新小说项目时激活 - 通过温和的提示和解释引导他们完成七步方法论（constitution → specify → clarify → plan → tasks → write → analyze）

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CLI/Python toolkit for rapid bioinformatics queries. Preferred for quick BLAST searches. Access to 20+ databases: gene info (Ensembl/UniProt), AlphaFold, ARCHS4, Enrichr, OpenTargets, COSMIC, genome downloads. For advanced BLAST/batch processing, use biopython. For multi-database integration, use bioservices.

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Master advanced Git workflows including rebasing, cherry-picking, bisect, worktrees, and reflog to maintain clean history and recover from any situation. Use when managing complex Git histories, collaborating on feature branches, or troubleshooting repository issues.

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Access and analyze comprehensive drug information from the DrugBank database including drug properties, interactions, targets, pathways, chemical structures, and pharmacology data. This skill should be used when working with pharmaceutical data, drug discovery research, pharmacology studies, drug-drug interaction analysis, target identification, chemical similarity searches, ADMET predictions, or any task requiring detailed drug and drug target information from DrugBank.

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Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends your capabilities with specialized knowledge, workflows, or tool integrations.

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Use when creating or updating pull requests with comprehensive descriptions and meaningful commits - streamlines PR workflow with branch management and commit best practices

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Comprehensive cryptocurrency market research and analysis using specialized AI agents. Analyzes market data, price trends, news sentiment, technical indicators, macro correlations, and investment opportunities. Use when researching cryptocurrencies, analyzing crypto markets, evaluating digital assets, or investigating blockchain projects like Bitcoin, Ethereum, Solana, etc.

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Create professional PDF reports with text, tables, and embedded images using reportlab. Works with ANY LLM provider (GPT, Gemini, Claude, etc.).

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Plan and execute database migrations, data transformations, and system migrations safely with rollback strategies and data integrity validation. Use when migrating databases, transforming data schemas, moving between database systems, implementing versioned migrations, handling data transformations, ensuring data integrity, or planning zero-downtime migrations.

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Optional advanced tool for complex data modeling. For simple table creation, use relational-database-tool directly with SQL statements.

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Execute database migrations across ORMs and platforms with zero-downtime strategies, data transformation, and rollback procedures. Use when migrating databases, changing schemas, performing data transformations, or implementing zero-downtime deployment strategies.

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Work with MongoDB (document database, BSON documents, aggregation pipelines, Atlas cloud) and PostgreSQL (relational database, SQL queries, psql CLI, pgAdmin). Use when designing database schemas, writing queries and aggregations, optimizing indexes for performance, performing database migrations, configuring replication and sharding, implementing backup and restore strategies, managing database users and permissions, analyzing query performance, or administering production databases.

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Pythonic wrapper around RDKit with simplified interface and sensible defaults. Preferred for standard drug discovery: SMILES parsing, standardization, descriptors, fingerprints, clustering, 3D conformers, parallel processing. Returns native rdkit.Chem.Mol objects. For advanced control or custom parameters, use rdkit directly.

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Molecular machine learning toolkit. Property prediction (ADMET, toxicity), GNNs (GCN, MPNN), MoleculeNet benchmarks, pretrained models, featurization, for drug discovery ML.

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Use when invalid data causes failures deep in execution, requiring validation at multiple system layers - validates at every layer data passes through to make bugs structurally impossible

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Implement DeFi protocols with production-ready templates for staking, AMMs, governance, and lending systems. Use when building decentralized finance applications or smart contract protocols.

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Multiagent AI system for scientific research assistance that automates research workflows from data analysis to publication. This skill should be used when generating research ideas from datasets, developing research methodologies, executing computational experiments, performing literature searches, or generating publication-ready papers in LaTeX format. Supports end-to-end research pipelines with customizable agent orchestration.

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Manage major dependency version upgrades with compatibility analysis, staged rollout, and comprehensive testing. Use when upgrading framework versions, updating major dependencies, or managing breaking changes in libraries.

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Analyzes your recent Claude Code chat history to identify coding patterns, development gaps, and areas for improvement, curates relevant learning resources from HackerNews, and automatically sends a personalized growth report to your Slack DMs.

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Retrieval-augmented generation (RAG) skill for the D&D 5e System Reference Document (SRD). Use when answering questions about D&D 5e core rules, spells, combat, equipment, conditions, monsters, and other SRD content. This skill provides agentic search-based access to the SRD split into page-range markdown files.

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Keeps IdeaVim documentation in sync with code changes. Use this skill when you need to verify documentation accuracy after code changes, or when checking if documentation (in doc/, README.md, CONTRIBUTING.md) matches the current codebase. The skill can work bidirectionally - from docs to code verification, or from code changes to documentation updates.

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Validate consistency across SEED Design component documentation layers (design guidelines in ./docs/content/docs/components, Rootage specs in ./packages/rootage/components, and React docs in ./docs/content/react/components). Use when auditing documentation completeness, before releases, or validating new component docs.

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Write documentation following Metabase's conversational, clear, and user-focused style. Use when creating or editing documentation files (markdown, MDX, etc.).

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