'cli' 검색 결과

Align preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and multi-mapper-aware alignment for repeat-binding RBPs, deciding STAR vs HISAT2 memory trade-offs, and applying ENCODE-compatible filters. Use when turning preprocessed CLIP FASTQ into a deduplicated, MAPQ-filtered BAM ready for peak calling or crosslink-site detection.

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Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.

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Audit and enforce the core/client boundary in multi-client projects. Detects where shared platform code is tangled with client-specific code, finds hardcoded client checks, config files that replace instead of merge, scattered client code, migration conflicts, and missing extension points. Produces a boundary map, violation report, and refactoring plan. Optionally generates FORK.md documentation and restructuring scripts. Triggers: 'fork discipline', 'check the boundary', 'is this core or client', 'platform audit', 'client separation', 'fork test', 'refactor for multi-client', 'clean up the fork'.

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Prepare for Chinese wealth management client meetings with performance summaries, talking points, and relationship context. Adapted from the original client-review skill for A-share portfolios and Chinese client conventions. Triggers on "A股客户回顾", "客户会议准备", "client review China", "wealth client review", "客户回访准备", or "prepare for client meeting [client]".

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Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Align preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and multi-mapper-aware alignment for repeat-binding RBPs, deciding STAR vs HISAT2 memory trade-offs, and applying ENCODE-compatible filters. Use when turning preprocessed CLIP FASTQ into a deduplicated, MAPQ-filtered BAM ready for peak calling or crosslink-site detection.

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Work with climate data, models, and projections for climate impact assessment, downscaling, and scenario analysis using CMIP6 and other climate datasets. Use when "climate model, climate projection, CMIP6, climate data, downscaling, climate scenario, RCP, SSP, global warming, " mentioned.

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arkcli 推理接入点管理与显式 raw CRUD 创建能力。**正向触发：用户明确要求脚本化 / CI / 无护栏 / 原始 raw CRUD 创建 Endpoint 时，必须使用本 skill 的 `arkcli infer endpoint create` 路径，不能切到 `arkcli-deploy`**；模型缺失或只有品牌/家族名时仍留在本 skill，先执行实时有界候选与 0/1/N 澄清，模型未唯一确定前禁止 preview 或创建。本 skill 也负责对**已有** Endpoint 做获取、列表、启动、停止、删除、更新，以及在 NotFound 后用当前完整列表 + 历史 usage 判断 ID 是否不完整或仅有历史记录。普通的『创建/新建/部署一个 endpoint』仍走带产品护栏的 arkcli-deploy（`+deploy`），只有用户明确选择上述原始路径才例外。优先使用产品命令 `arkcli infer endpoint ...`，而不是 Raw API。TTS/ASR/语音模型连 raw create 也不要引导，只能转 models search 说明 arkcli 不支持 Endpoint 创建。

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arkcli 模型查询与基础模型服务激活能力：列出、搜索、获取火山公共基础模型详情，以及用户明确要求的开通/激活模型服务（`arkcli models activate`）；Volc 还支持 TTFT/TPOT 性能排名、延迟趋势和输入长度对比。激活已有基础模型服务不等于部署/创建 Endpoint，不得转成 `+deploy`。优先使用产品命令 `arkcli models ...`，而不是直接调用 Raw API。反触发：用户的最终目标是创建 / 部署 Endpoint 时，本 skill 承担有界的只读候选查询，owning skill 由创建路径确定：普通产品创建走 arkcli-deploy；用户显式要求 raw CRUD / CI / 无守卫的 `infer endpoint create` 走 arkcli-infer-endpoint。候选首先执行 `models search ... --size 10 --format json`；成功完整结果直接复用，空结果与捕获缺损按 reference 有界恢复，并把实时返回的 `name` 与非空 `primary_version` 组合成可直接传给 `--model` 的完整 ID，不能拉全量清单、把裸家族名当可部署 ID，或逐候选追加 `models get`。注意：查询/管理账号下自传或精调的自定义模型（`cm-xxx`）走 arkcli-custommodel。

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飞书官方 CLI 工具 (lark-cli)，在终端中操作飞书。覆盖消息、文档、多维表格、电子表格、 日历、邮箱、任务、会议、审批等 12 大业务域，提供 200+ 命令。 当需要通过 CLI 方式操作飞书（而非飞书 OAuth API）时使用此 Skill。 触发词："lark-cli"、"飞书CLI"、"飞书命令行"、"lark命令"。 适用场景： (1) 需要通过命令行执行飞书操作（发消息、查日程、读写文档等） (2) 需要批量操作飞书数据 (3) AI Agent 需要以用户/机器人身份调用飞书 API (4) 需要底层 API 调试或 schema 查询 (5) 用户提到 "lark-cli"、"飞书CLI"

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Troubleshoot and resolve common issues with the ClickHouse Node.js client (@clickhouse/client). Use this skill whenever a user reports errors, unexpected behavior, or configuration questions involving the Node.js client specifically - including socket hang-up errors, Keep-Alive problems, stream handling issues, data type mismatches, read-only user restrictions, proxy/TLS setup problems, or long-running query timeouts. Trigger even when the user hasn't precisely named the issue; vague symptoms like "my inserts keep failing" or "connection drops randomly" in a Node.js context are strong signals to use this skill. Do NOT use for browser/Web client issues.

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Keep paperclip-docs in lockstep with the parent paperclipai/paperclip codebase. Detects code-surface changes (CLI, env vars, API routes, adapters, plugin SDK, schemas) and produces friendly-tutorial-voice doc updates. Two modes — `nightly` (tracks parent's default branch (currently `master`), targets the `nightly` branch, preview deploy) and `release` (on parent tag, merges nightly → main, tags, ships live). Trigger phrases: "sync docs", "update docs from paperclip", "/sync-docs", "check for paperclip changes", "is docs current".

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Guide for annotating ENCODE regulatory variants with ClinVar clinical significance. Use when users need to check if variants in ENCODE peaks have clinical associations, find pathogenic variants in regulatory regions, or assess variant clinical impact. Trigger on: ClinVar, clinical significance, pathogenic variant, variant classification, clinical variant, disease variant, VUS, benign, likely pathogenic.

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Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Align preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and multi-mapper-aware alignment for repeat-binding RBPs, deciding STAR vs HISAT2 memory trade-offs, and applying ENCODE-compatible filters. Use when turning preprocessed CLIP FASTQ into a deduplicated, MAPQ-filtered BAM ready for peak calling or crosslink-site detection.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Create a ClickHouse materialization to stream Estuary collections into ClickHouse tables. Use when setting up ClickHouse as a destination for captured data. Use when user says "send to ClickHouse", "materialize to ClickHouse", "ClickHouse destination", or "load into ClickHouse".

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Align preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and multi-mapper-aware alignment for repeat-binding RBPs, deciding STAR vs HISAT2 memory trade-offs, and applying ENCODE-compatible filters. Use when turning preprocessed CLIP FASTQ into a deduplicated, MAPQ-filtered BAM ready for peak calling or crosslink-site detection.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Align preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and multi-mapper-aware alignment for repeat-binding RBPs, deciding STAR vs HISAT2 memory trade-offs, and applying ENCODE-compatible filters. Use when turning preprocessed CLIP FASTQ into a deduplicated, MAPQ-filtered BAM ready for peak calling or crosslink-site detection.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.