'compound' 검색 결과

Use when an agent needs to drive a real Chrome window via opencli — inspect a page, fill forms, click through logged-in flows, or extract data ad-hoc. Covers the selector-first target contract, compound form fields, stale-ref handling, network capture, and the agent-native envelopes the CLI returns. Not for writing adapters — see opencli-adapter-author for that.

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A persistent, compounding knowledge base combining Karpathy's LLM Wiki pattern with a structured knowledge graph. Ingest documents once — the LLM writes wiki pages, extracts entities/relations into the graph, and stores raw content for evidence retrieval. Knowledge accumulates and cross-references; it is never re-derived from scratch. Use when building a knowledge base from many documents that should accumulate and cross-reference over time instead of being re-read each session.

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Patterns for scaling read-heavy Convex apps to millions of users. Use when optimizing bandwidth, reducing query costs, fixing slow queries, creating digest tables, replacing reactive subscriptions with one-shot fetches, adding compound indexes, debouncing writes, rate-controlling backfills, or running npx convex insights. Trigger when users mention "scale", "bandwidth", "performance", "optimize", "slow queries", "expensive queries", "digest table", "denormalize", or "thundering herd" in the context of Convex.

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Patterns for scaling read-heavy Convex apps to millions of users. Use when optimizing bandwidth, reducing query costs, fixing slow queries, creating digest tables, replacing reactive subscriptions with one-shot fetches, adding compound indexes, debouncing writes, rate-controlling backfills, or running npx convex insights. Trigger when users mention "scale", "bandwidth", "performance", "optimize", "slow queries", "expensive queries", "digest table", "denormalize", or "thundering herd" in the context of Convex.

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React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.

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React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.

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15-minute daily taste exercises. Monday through Friday. Compound effect over time. Use when building personal practice habits, training a team's design eye, or adding structure to professional development.

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VibeFarsi component integration: production-level official CLI, compound states, RTL. Use when implementing, reviewing or testing vibefarsi component integration for React, Vite, Next.js or Perfect_AI projects.

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Patterns for scaling read-heavy Convex apps to millions of users. Use when optimizing bandwidth, reducing query costs, fixing slow queries, creating digest tables, replacing reactive subscriptions with one-shot fetches, adding compound indexes, debouncing writes, rate-controlling backfills, or running npx convex insights. Trigger when users mention "scale", "bandwidth", "performance", "optimize", "slow queries", "expensive queries", "digest table", "denormalize", or "thundering herd" in the context of Convex.

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Productivity analyst that maps your workflow, scores tasks by time cost and energy drain, and builds a prioritized 4-week automation plan. Use when you want to audit your workflow, figure out what to automate, do a productivity review, identify high-leverage tasks, feel overwhelmed and need to prioritize, or after the compounder surfaces new friction. Part of the architect-system loop. Outputs to system/audit-report.md.

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Master orchestrator for the 5-step productivity loop. Runs audit, architect, analyst, refinery, and compounder in sequence or individually. Use when you want to run the full loop, start the system, check system status, resume from where you left off, or run a specific step. Manages state, sequencing, and skill chaining. Supports full loop, single step, resume, and status-only modes.

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Master orchestrator for the 5-step productivity system. Runs the full audit-architect-analyst-refinery-compounder loop or individual steps. Use when: (1) "run the full loop", "start the system", "architect system", (2) "run step N", "run audit", "run architect", (3) "what step am I on?", "system status", "where am I in the loop?", (4) "continue", "resume", "next step". Manages state, sequencing, and skill chaining across all 5 steps.

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Autonomous agents are AI systems that can independently decompose goals, plan actions, execute tools, and self-correct without constant human guidance. The challenge isn't making them capable - it's making them reliable. Every extra decision multiplies failure probability. This skill covers agent loops (ReAct, Plan-Execute), goal decomposition, reflection patterns, and production reliability. Key insight: compounding error rates kill autonomous agents. A 95% success rate per step drops to 60% b

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React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.

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Dose-response / concentration-response curve fitting — IC50, EC50, Hill slope, Emax/Emin efficacy, and relative potency from paired concentration vs response data (enzyme/cell assays, drug screening, agonist/antagonist pharmacology). Fits the 4-parameter logistic (Hill sigmoidal) model. Use when you have concentrations + responses and need a potency value, to compare two compounds' potency, or to judge curve quality. NOT for image-derived dose-response (use tooluniverse-image-analysis) and NOT for survival/regression (use tooluniverse-statistical-modeling).

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Comprehensive ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiling for drug candidates. Integrates ADMET-AI predictions, SwissADME drug-likeness, PubChemTox experimental toxicity, ChEMBL clinical data, Lipinski rule-of-five, and CYP interaction data. Use for drug-likeness assessment, BBB penetration, bioavailability, hepatotoxicity prediction, ADME/PK profiling, or screening compound libraries before lab testing.

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Small molecule identification, characterization, and procurement — PubChem, ChEMBL, BindingDB, ADMET-AI, SwissADME, eMolecules, Enamine. Covers compound name to structure to activity to ADMET properties to commercial sourcing. Use for chemical biology, lead identification, probe selection, and the full small-molecule discovery pipeline.

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Identify drug repurposing candidates via target-based, compound-based, and disease-based strategies. Combines drug-target-disease network reasoning with mechanism rationale, clinical-trial precedent, and patent/regulatory feasibility. Use for hypothesis-generating repurposing for orphan diseases, finding existing drugs for new indications, and prioritizing candidates by evidence and feasibility.

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Compound-target-disease network construction and analysis for drug repurposing, polypharmacology discovery, and multi-target drug design. Uses STRING, BioGRID, ChEMBL, DGIdb, OMIM, OpenTargets. Use for off-target effect prediction, network-based drug repurposing, and identifying molecules with desired multi-target profile.

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Retrieve structurally similar compounds with known properties from ChEMBL/ZINC to ground predictions and inform optimization. Based on MolRAG (Xian 2025, ACL).

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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.

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Performs molecular similarity searching using Tanimoto, Tversky, Dice, and cosine coefficients on bit/count fingerprints with explicit choice rules for symmetric vs asymmetric measures, scaffold-hopping vs lead-optimization regimes, activity-cliff diagnosis, and large-library nearest-neighbor methods (BulkTanimoto, Annoy MHFP6, USRCAT). Use when ranking compounds by structural resemblance to a query, clustering libraries, finding analogs, or diagnosing activity cliffs.

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Biological knowledge: query curated assertions and reference databases for genes, variants, pathways, regulation, cell types, reference atlases, perturbation-derived relationships, phenotypes, therapeutic targets, drugs, interactions, annotations, signatures, compounds, and predicted structures. Use for identifiers, marker sets, gene sets, associations, ontologies, database facts, and cross-database coverage.

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Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioisosteric replacements, prospective scaffold hopping, or expanding hit series beyond 2D similarity.

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