'opa' 검색 결과

Query and download from NCBI Gene Expression Omnibus (GEO) and EMBL-EBI's BioStudies/ArrayExpress mirror. Use when finding expression datasets, navigating SuperSeries vs SubSeries, choosing between series-matrix (submitter-normalized) and raw supplementary files, downloading via GEOparse (Python) or GEOquery (R/Bioconductor), linking GEO to SRA for raw reads, or distinguishing GSE/GSM/GPL/GDS record types. Encodes the SuperSeries trap, the series-matrix normalization-trust caveat, GEOmetadb deprecation, ArrayExpress migration to BioStudies, and processed-vs-raw decision matrix.

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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.

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Infer orthologous genes and gene families across species using OrthoFinder3 (HOG-based phylogenetic orthology), SonicParanoid2, Broccoli, ProteinOrtho, OMA / FastOMA hierarchical orthologous groups, eggNOG-mapper, JustOrthologs, and TOGA whole-genome-alignment orthology. Use when building single-copy ortholog sets for phylogenomics, classifying co-orthologs and in/out-paralogs after gene duplication, propagating functional annotation via orthology with awareness of the ortholog conjecture, distinguishing speciation from duplication via gene-tree species-tree reconciliation, computing Quest-for-Orthologs benchmark performance, or running synteny-aware ortholog detection in WGD-affected lineages.

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Investigates DAG incidents with a precise top event, timeline, competing hypotheses, barriers, propagation, and bounded recovery. NOT for automated root-cause classification, trace collection, or performance profiling.

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Building resilient distributed systems with circuit breakers, retries with full-jitter exponential backoff, retry budgets (per-request 3-attempt + per-client 10% ratio per Google SRE), deadline propagation, and the cascading-failure math (4 layers × 3 retries = 64x amplification). Grounded in Resilience4j, Microsoft Cloud Patterns, AWS Architecture Blog (Marc Brooker), and Google SRE Book. NOT for server-side rate limiting, bulkhead isolation, backpressure protocols, or database-specific retry.

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Track the full Toulmin epistemic ancestry of every claim produced by a multi-agent swarm. Each agent output is tagged with an argument chain (claim / data / warrant / relationship) derived from SwarmTracer spans and LineageEdge records, so operators can zoom into any sub-claim and see precisely which agents asserted it, what triggered each assertion, and how contradictions propagated or were synthesised away. The SwarmTracer pattern — wrapping the SwarmAgentExecutor to capture spans, record messages, and build a lineage graph — is the concrete runtime substrate. Argumentative lineage lifts that graph into the Toulmin vocabulary so reasoning provenance is both machine-queryable and human-interpretable.

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Produces a narrow-interval quality signal for a WinDAGs skill that a third party can verify without inspecting model weights or method internals. The mechanism is attribution-kNN over a tamper-evident outcome log (task→skills→accept/reject store), combined with a conformal-prediction calibration certificate that provides a formal coverage guarantee. Thompson/Beta sampling is explicitly rejected as a category error: it produces a selection signal for stationary i.i.d. rewards, not an attestation signal for context-dependent LLM output quality. The resulting bundle — outcome-log Merkle root + conformal threshold + optional TEE guardrail signature — constitutes a "narrow-interval trust" credential: verifiable, bounded, and internals-opaque.

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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.

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Generates PSR-14 Event Dispatcher implementation for PHP 8.5. Creates EventDispatcherInterface, ListenerProviderInterface, and StoppableEventInterface with event propagation. Includes unit tests.

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Adds debugging capabilities and troubleshoots Pine Script issues in TradingView's opaque environment. Use when scripts have errors, unexpected behavior, need debugging tools added, or require troubleshooting. Triggers on "debug", "fix", "error", "not working", "wrong values", or troubleshooting requests.

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Generate UK/EU GDPR compliance documents — privacy policies, cookie policies, DPIAs, ROPA, DSAR responses, data breach notifications, and consent forms. Use when a business needs GDPR documentation, data protection policies, or privacy compliance.

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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.

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Detect and prevent privilege escalation in Kubernetes pods by monitoring security contexts, capabilities, and syscall patterns with Falco and OPA policies.

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Auditing Terraform infrastructure-as-code for security misconfigurations using Checkov, tfsec, Terrascan, and OPA/Rego policies to detect overly permissive IAM policies, public resource exposure, missing encryption, and insecure defaults before cloud deployment.

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Review a Go design spec before implementation begins - dispatch a subagent that checks a design doc for completeness, consistency, and idiomatic Go (simplicity, small consumer-defined interfaces, explicit wrapped errors, context propagation) plus Cobra/Viper conventions where applicable. Use when a user has a Go spec to review, asks "is this spec ready?", or is about to implement from a written design. Distilled from spf13/go-skills and adapted to this repo's conventions.

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Comprehensive Linux privilege escalation methodology for offensive security engagements. Covers the full attack surface from a low-privilege shell to root: SUID/SGID binary abuse via GTFOBins, Linux capabilities exploitation (cap_setuid, cap_dac_override, cap_dac_read_search), sudo misconfigurations including NOPASSWD rules and Baron Samedit (CVE-2021-3156), cron job abuse through writable scripts, PATH hijacking, and wildcard injection with tar/rsync/chown. Includes writable /etc/passwd attacks, NFS no_root_squash exploitation, kernel exploits (DirtyPipe CVE-2022-0847, DirtyCow CVE-2016-5195, PwnKit CVE-2021-4034), Docker group container escapes, LD_PRELOAD and LD_LIBRARY_PATH hijacking for shared library injection, systemd service misconfigurations, and sensitive file enumeration for credential harvesting. Integrates automated enumeration with LinPEAS, linux-exploit-suggester, pspy for process monitoring, and GTFOBins for binary exploitation. Each technique includes detection signatures and defender-sid...

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Complete reference for 26 web2 bug classes with root causes, detection patterns, bypass tables, exploit techniques, and real paid examples. Covers IDOR, auth bypass, XSS, SSRF (11 IP bypass techniques), SQLi, business logic, race conditions, OAuth/OIDC, file upload (10 bypass techniques), GraphQL, LLM/AI (ASI01-ASI10 agentic framework), API misconfig (mass assignment, JWT attacks, prototype pollution, CORS), ATO taxonomy (9 paths), SSTI (Jinja2/Twig/Freemarker/ERB/Spring), subdomain takeover, cloud/infra misconfigs, HTTP smuggling (CL.TE/TE.CL/H2.CL), cache poisoning, MFA bypass (7 patterns), SAML attacks (XSW/comment injection/signature stripping), error disclosure / debug endpoints (stack trace regex per framework, chain templates), CSS injection (attribute-selector exfiltration, opacity clickjacking, @import). LFI / file inclusion -> RCE (php://filter source disclosure, iconv filter-chain RCE with no upload, log/environ poisoning, .user.ini/.htaccess auto_prepend, data:// + expect:// wrappers, session inclusion, traversal bypass table). Insecure deserialization (PHP __wakeup bypass / phar:// POP chains, Java ysoserial CommonsCollections gadgets + magic bytes, Python pickle __reduce__ + signed-cookie forgery, Node node-serialize). Dependency confusion / supply chain (internal package-name discovery, unclaimed-name confirmation, callback-only PoC, npm/pip/Maven/RubyGems variants). Use when hunting a specific vuln class or studying what makes bugs pay.

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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.