'phase arc' 검색 결과

Parses, queries, converts, and extracts from GTF and GFF3 gene-model annotation files - walking the gene/transcript/exon/CDS hierarchy with gffutils (queryable SQLite DB), converting formats and extracting transcript/CDS/protein FASTA with gffread, slurping to dataframes with gtfparse/pyranges, and sanitizing malformed files with AGAT. Covers the 1-based-inclusive vs 0-based BED coordinate conversion (start-1 only), deriving implicit features (introns/UTRs/TSS), phase-not-frame, the stop-codon-in-or-out-of-CDS convention, and the chr1-vs-1 seqid and gene-ID-version mismatches that silently produce all-zero count matrices and dropped joins. Use when extracting features or sequences from an annotation, converting GTF<->GFF3 or GTF->BED, traversing the gene tree, or diagnosing a coordinate/provenance mismatch upstream of counting or DE.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Create a detailed, step-by-step implementation plan for a feature or project. Load when the user asks to plan a feature, create a technical roadmap, break down a PRD into tasks, design an implementation strategy, or sequence engineering work. Also triggers on "how should we build this", "implementation plan for", "technical breakdown", "task list for", or any request to turn a high-level requirement into a concrete execution plan. Supports phased rollouts, architecture-first, and MVP-focused planning.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Parses, queries, converts, and extracts from GTF and GFF3 gene-model annotation files - walking the gene/transcript/exon/CDS hierarchy with gffutils (queryable SQLite DB), converting formats and extracting transcript/CDS/protein FASTA with gffread, slurping to dataframes with gtfparse/pyranges, and sanitizing malformed files with AGAT. Covers the 1-based-inclusive vs 0-based BED coordinate conversion (start-1 only), deriving implicit features (introns/UTRs/TSS), phase-not-frame, the stop-codon-in-or-out-of-CDS convention, and the chr1-vs-1 seqid and gene-ID-version mismatches that silently produce all-zero count matrices and dropped joins. Use when extracting features or sequences from an annotation, converting GTF<->GFF3 or GTF->BED, traversing the gene tree, or diagnosing a coordinate/provenance mismatch upstream of counting or DE.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Generates comprehensive, workable unit tests for any programming language using a multi-agent pipeline. Use when asked to generate tests, write unit tests, improve test coverage, add test coverage, create test files, or test a codebase. Supports C#, TypeScript, JavaScript, Python, Go, Rust, Java, and more. Orchestrates research, planning, and implementation phases to produce tests that compile, pass, and follow project conventions.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Archive accumulated phase directories from completed milestones

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Two-phase Apollo.io prospecting: free People Search to discover ICP-matching leads, then selective enrichment to reveal emails/phones (credits per contact). Deduplicates against CRM (Google Sheets). Supports Apollo API and MCP tools.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.